CAS: 583-55-1; 1-Bromo-2-Iodobenzene

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CAS号615-36-1 2-溴苯胺 | CAS号108-86-1 溴苯 | CAS号244205-40-1 2-溴苯硼酸 | CAS号591-50-4 碘苯 | CAS号2712-78-9 [双(三氟乙酰氧基)碘]苯 | CAS号88-65-3 邻溴苯甲酸 | CAS号583-53-9 1,2-二溴苯 | CAS号19260-00-5 o-bromodibenzoy... | CAS号22424-65-3 1-Iod-2-(trimet... | CAS号100-39-0 溴化苄 | CAS号508233-74-7 沃替西汀 | CAS号50777-76-9 2-二苯基膦苯甲醛 | CAS号494773-35-2 4-(2-溴苯基)哌嗪-1-羧酸叔丁酯 | CAS号38274-16-7 (2-溴苯乙炔基)三甲基硅烷 | CAS号149989-79-7 2-溴苄基硼酸频哪醇酯 | CAS号143192-60-3 1-ethynyl-2-(2-... | CAS号92-39-7 2-氯吩噻嗪 | CAS号4453-90-1 1,4-二氢-1,4-甲桥萘 | CAS号4169-19-1 1-乙酰基-1,2,3,4-四氢喹啉 | CAS号4688-76-0 2-联苯硼酸

邻二氯苯置于n-溴代丁二酰亚胺(Nbs),N-碘代丁二酰亚胺,Magnesium,Lithium Chloride体系中,用 溶剂黄146 作为反应溶剂,化学反应 41.0H,反应生成 邻碘溴苯
参考文献:Copper-Free Double Silylation Of 1,2-Dibromobenzenes Using A Mg/licl/dmi System
标题:Copper-Free Double Silylation Of 1,2-Dibromobenzenes Using A Mg/licl/dmi System
摘要:1,2-二溴苯与氯三甲基硅烷在dmi中在温和条件下,在mg和licl存在下高效进行反应,产率非常好至高.1,2-二溴苯与氯二甲基硅烷在相同条件下反应,得到相应的1,2-二(二甲基硅基)苯,产率高.对1,2-二(三甲基硅基)苯进行了功能团转化,以展示其合成效用.
DOI:10.1055/s-0036-1588726

专利信息

专利号:EP-2103609-A1
优先权日:2008-03-20
标 题:Catalyzed carbonylation in the synthesis of angiotensin ii antagonists
权利人:LEK PHARMACEUTICALS
摘要:One embodiment disclosed in the invention is the efficient synthesis of halogenated biaryl starting material via Grignard chemistry and the use thereof. Another embodiment of the invention is the reaction of catalyzed carbonylation of the 3'-(2'-halo-biphenyl-4-ylmethyl)-1,7'-dimethyl-2'-propyl-1H,3'H-[2,5']bibenzoimidazolyl (TLMH) using either gaseous carbon monoxide in a solvent mixture containing water; or formic acid salts optionally together with acetic acid in anhydrous solvent.

专利号:US-8445693-B2
优先权日:2008-03-20
标 题 :Catalyzed carbonylation in the synthesis of angiotensin II antagonists
发明人：CASAR ZDENKO; COPAR ANTON; CLUZEAU JEROME; PREMRL ANDREJ
权利人:CASAR ZDENKO; COPAR ANTON; CLUZEAU JEROME; PREMRL ANDREJ; LEK PHARMACEUTICALS
摘要:One embodiment disclosed in the invention is the efficient synthesis of halogenated biaryl starting material via Grignard chemistry and the use thereof. Another embodiment of the invention is the reaction of catalyzed carbonylation of the 3′-(2′-halo-biphenyl-4-ylmethyl)-1,7′-dimethyl-2′-propyl-1H,3′H-[2,5′]bibenzoimidazolyl (TLMH) using either gaseous carbon monoxide in a solvent mixture containing water; or formic acid salts optionally together with acetic acid in anhydrous solvent.

专利号:US-10562872-B2
优先权日:2016-02-08
标 题 :Synthesis of 1-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]piperazine
发明人：DINESS FREDERIK; MELDAL MORTEN; JACOBSEN CHRISTIAN BORCH
权利人:H LUNDBECK AS
摘要:The invention relates to a method for synthesis of 1-[2-(2,4-Dimethyl-phenylsulfanyl)-phenyl]piperazine in the presence of a strong base.

专利号:WO-2018217538-A1
优先权日:2017-05-23
标题 :Synthesis of substituted acridines
发明人：FORT ERIC H; JAYE JOSEPH A; MCCORMICK GRANT M; BERGER KRISTEN E
权利人:UNIV OF ST THOMAS
摘要:Disclosed is a method of making substituted acridines. The method includes the step of reacting a bis(halophenyl) amine with an alkyne for a time and at a temperature to yield a substituted acridine.

专利号:US-10865163-B2
优先权日:2017-12-20
标题:Carbon dioxide as a directing group for C—H functionalization reactions involving Lewis basic amines, alcohols, thiols, and phosphines for the synthesis of compounds
发明人：YOUNG MICHAEL C; KAPOOR MOHIT
权利人:UNIV TOLEDO
摘要:Methods of synthesizing compounds using CO 2 as a directing group for C—H functionalization, and compounds made thereby, are described.

专利号:US-9493409-B2
优先权日:2013-04-04
标题 :Process for the synthesis of 1-(2-((2,4-dimethylphenyl)thio)phenyl)piperazine
发明人：ZUPANCIC BORUT
权利人:LEK PHARMACEUTICALS
摘要:The present invention provides new intermediate compounds or formulae (III) and (IVa), and salts thereof, and their use in a new synthetic process for the production of 1-(2-((2,4-dimethylphenyl)thio)phenyl)piperazine (vortioxetine) an experimental drug under development for the treatment of depression and anxiety.