CAS: 52744-13-5; 2,2',3,3',5,6'-Hexachlorobiphenyl

该化合物是多氯联苯(PCB)家族的成员,是合成有机化学品,以其环境持久性和潜在毒性而著称;该化合物的六氯原子代之以双苯结构,这大大改变了其物理和化学特性;该化合物一般在室内温度下是固体,具有低挥发性,因此具有抗降解的抗药性;多种氯原子的存在会加剧其疏水性,导致生物体中的生物累积性,并导致食物链中潜在的生物放大作用;已知2,2',3,3',5,6'-六氯联苯具有稳定性和抗化学反应性,有助于其环境持久性;该化合物与各种不良健康影响有关,包括内分泌干扰和潜在致癌性;由于这些特性,包括这种化合物在内的多氯联苯的使用在许多国家受到严格管制或禁止;环境监测和补救工作对于管理其生态系统存在的风险至关重要.

英文名称2,2',3,3',5,6'-Hexachlorobiphenyl
中文名称2,2',3,3',5,6'-六氯联苯
IUPAC名称1,2,4-trichloro-3-(2,3,5-trichlorophenyl)benzene
其它别名2,2',3,3',5,6'-Hexachlorobiphenyl; 2,2',3,5,5',6'-Hexachlorobiphenyl; 2,3,5,2',3',6'-Hexachlorobiphenyl
CAS编号52744-13-5
MFCD编号:MFCD00792635
FDA UNII编号:5XD09W9A7A
分子式:C12H4Cl6分子量:360.88
产品CID: 2496384
产品分类分析化学 → 食品安全 → 二噁英，多氯联苯，呋喃

相似结构搜索
产品信息参考;;;;
InChIKey: UUTNFLRSJBQQJM-UHFFFAOYSA-N
1S/C12H4Cl6/c13-5-3-6(11(17)9(16)4-5)10-7(14)1-2-8(15)12(10)18/h1-4H
计算化学: 氢键受体数*氢键供体数0.0可旋转键数1.0

MSDS等安全信息

危险描述Not Classified
Reported as not meeting GHS hazard criteria by 3 of 3 companies. For more detailed information, please visit ECHA C&L website.
安全声明The mechanism of action varies with the specific PCB. Dioxin-like PCBs bind to the aryl hydrocarbon receptor, which disrupts cell function by altering the transcription of genes, mainly be inducing the expression of hepatic Phase I and Phase II enzymes, especially of the cytochrome P450 family. Most of the toxic effects of PCBs are believed to be results of Ah receptor binding. Other PBCs are believed to interfere with calcium channels and/or change brain dopamine levels. PCBs can also cause endocrine disurption by altering the production of thyroid hormones and binding to estrogen receptors, which can stimulate the growth of certain cancer cells and produce other estrogenic effects, such as reproductive dysfunction. They will bioaccumulate by binding to receptor proteins such as uteroglobin. (A3, A4, A30, A66)

合成工艺路线路线简述

📜三氯苯胺,三氯苯置于sodium Acetate,亚硝酸体系中,化学反应生成 2,2',3,3',5,6'-六氯联苯
参考文献:Physical,Spectral And Chromatographic Properties Of All 209 Individual Pcb Congeners
标题:Physical,Spectral And Chromatographic Properties Of All 209 Individual Pcb Congeners
摘要:Physical,Spectral And Chromatographic Data For All 209 Individual Pcb Congeners Is Presented. The Individual Congeners Were Synthesized And Then Isolated And Purified. Recent Emphasis On The Source Of The Toxicity Of Commercial Pcb Formulations Has Increased The Need For A Complete Set Of The Pcb Congeners. Through The Use Of Two Capillary Gc Columns: 40% octadecyl/ 15% Phenyl Methyl Siloxane And 50% Phenyl Methyl Siloxane,It Was Possible To Separate 201 Pcb Congeners With Only Four Unresolved Pairs. The Data Compiled In This Study For All 209 Congeners Will Aid In The Identification Of Selected Individual Components Of These Environmental Pollutants. The Use Of This Data Also Presents The Opportunity For The Improved Quantification Of The Commercial Pcb Formulations.
DOI:10.1016/0045-6535(95)00140-4