CAS: 2854-32-2; 2-(1-(4-Chlorobenzoyl)-5-Methoxy-2-Methyl-1H-Indol-3-yl)-1-Morpholinoethanone

该化合物是一种复杂的有机化合物,其特点是其非丁结构,这是一种由苯环结合成的双循环化合物,它由一种苯环组成,与一个发烧环组成;该物质具有氯苯乙烯组,一种甲基氧基组和一个单光酚组,有助于其不同的化学特性和潜在的生物活动;该物质的存在可能会加强其脂性,而本氯苯基分子组则会影响其药理学特征;该化合物可能表现出与生物目标的各种相互作用,从而引起对医药化学和药物开发的兴趣;其合成和特征通常涉及标准的有机反应,并可能对其在各种应用中的功效进行评估,包括作为一种潜在的治疗剂.

结构式图片

上下游产品

CAS号110-91-8 吗啉 | CAS号53-86-1 吲哚美辛 | CAS号2882-15-7 5-甲氧基-2-甲基-3-吲哚乙酸 | CAS号122-01-0 4-氯苯甲酰氯

合成工艺路线路线简述

    📜5-甲氧基-2-甲基-3-吲哚乙酸置于六甲基磷酰三胺,双(三甲基硅烷基)氨基钾,N,N'-二环己基碳二亚胺体系中,用 四氢呋喃 用作溶剂,化学反应生成2-[1-(4-氯苯甲酰基)-5-甲氧基-2-甲基-1H-吲哚-3-基]-1-(4-吗啉基)乙酮
    参考文献:New Class Of Potent Ligands For The Human Peripheral Cannabinoid Receptor
    标题:New Class Of Potent Ligands For The Human Peripheral Cannabinoid Receptor
    摘要:A New Class Of Potent Ligand For The Human Peripheral Cannabinoid (Hcb(2)) Receptor Is Described. Two Indole Analogs 13 And 17 Exhibited Nanomolar Potencies (K-I) With Good Selectivity For The Hcb(2) Receptor Over The Human Central Cannabinoid (Hcb(1)) Receptor. Copyright (C) 1996 Elsevier Science Ltd
    Doi:10.1016/0960-894X(96)00426-X

    海关参考信息

    专利信息


    专利号:WO-2025128903-A1
    优先权日:2023-12-13
    标题:Novel synthesis of substituted tricyclic compounds
    发明人:WANG SILAS; BECK HILARY; RAMOS ANGEL
    权利人:EIKON THERAPEUTICS INC
    摘要:Processes for preparing compounds of the general formula (VIII) from a compound of general formulat (V) via the aldehyde intermediate (VI), which is combined with the compound of general formula (VII): A process for preparing the compound of formula (III) from a compound of formula (II) via the aldehyde intermediate (I), which is combined with the compound of formula (IV):

    专利号:US-11891406-B2
    优先权日:2019-03-14
    标题:Conductivity enhancement of MOFs via development of MOFpolymer composite material
    发明人:PEEDIKAKKAL ABDUL MALIK P; AL-BETAR ABDUL-RAHMAN; AL-MOUSA AMMAR HUSSAIN
    权利人:UNIV KING FAHD PET & MINERALS
    摘要:A method for enhancing the conductivity of MOF-5 by the development of an MOF-5 polymer composite material. The composite material incorporates a conductive polymer, preferably polyaniline, in the solvo-thermal synthesis pathway of MOF-5. The electrically conductive MOF-5 composite exhibits electric conductivity three orders of magnitude higher than that of MOF-5 while maintaining the crystallinity, robustness, and thermal stability of MOF-5.

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    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献


    1: Zhang Q, Ma P, Cole RB, Wang G. In vitro metabolism of indomethacin morpholinylamide (BML-190), an inverse agonist for the peripheral cannabinoid receptor (CB(2)) in rat liver microsomes. Eur J Pharm Sci. 2010 Sep 11;41(1):163-72. doi: 10.1016/j.ejps.2010.06.004. Epub 2010 Jun 11.
    2: Zhang L, Zhang X, Wu P, Li H, Jin S, Zhou X, Li Y, Ye D, Chen B, Wan J. BML-111, a lipoxin receptor agonist, modulates the immune response and reduces the severity of collagen-induced arthritis. Inflamm Res. 2008 Apr;57(4):157-62. doi: 10.1007/s00011-007-7141-z. Epub 2007 Jan 4.
    5: New DC, Wong YH. BML-190 and AM251 act as inverse agonists at the human cannabinoid CB2 receptor: signalling via cAMP and inositol phosphates. FEBS Lett. 2003 Feb 11;536(1-3):157-60.

    合成参考文献


    摘要:Bollettino Chimico Farmaceutico., 114(309), 1975 []
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