CAS: 213699-53-7; 5-(((3,4-Dimethoxyphenyl)Amino)Methylene)-2,2-Dimethyl-1,3-Dioxane-4,6-Dione

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5-methoxymethylene-2,2-dimethyl-1,3-dioxane-4,6-dione 3,4-dimethoxyaniline cycl-isopropylidene malonate orthoformic acid triethyl ester 6,7-dimethoxyquinoline-4-ol 5,6-dimethoxy-quinolin-4-ol 1,4-dihydro-6,7-dimethoxy-4-oxoquinoline 6,7dimethoxy4(4nitrophenoxy)quinoline

📜丙二酸环(亚)异丙酯 以 N,N-二甲基甲酰胺 用作溶剂,化学反应 3.0H,反应生成卡博替尼杂质hf
参考文献:Synthesis Of Ring-Substituted 4-Aminoquinolines And Evaluation Of Their Antimalarial Activities
标题:Synthesis Of Ring-Substituted 4-Aminoquinolines And Evaluation Of Their Antimalarial Activities
摘要:A Simple Two-Step Synthesis Method Was Used To Make 51 B-Ring-Substituted 4-Hydroxyquinolines Allowing Analysis Of The Effect Of Ring Substitutions On Inhibition Of Growth Of Chloroquine Sensitive And Resistant Strains Of Plasmodium Falciparum,The Dominant Cause Of Malaria Morbidity. Substituted Quinoline Rings Other Than The 7-Chloroquinoline Ring Found In Chloroquine Were Found To Have Significant Activity Against The Drug-Resistant Strain Of P. Falciparum W2. (C) 2004 Elsevier Ltd. All Rights Reserved.
Doi:10.1016/j.Bmcl.2004.12.037