CAS: 21018-84-8; (2S,3R,4S,5S,6R)-4,5-Dihydroxy-6-(Hydroxymethyl)-2-(((3S,4R,4As)-8-Oxo-4-Vinyl-3,4,4A,5,6,8-Hexahydropyrano[3,4-C]Pyran-3-yl)Oxy)Tetrahydro-2H-Pyran-3-Yl 3,3',5-Trihydroxy-[1,1'-Biphenyl]-2-Carboxylate
该化合物是一种自然形成的化合物,被归类为单子状腺素,主要存在于某些植物中,特别是根地纳切埃氏家族,以其苦味著称,而且往往与各种药性有关.亚马罗尼基的化学结构包括一种与子细胞核相连的葡萄糖,有助于其生物活动.该化合物已引起人们的兴趣,使其具有潜在的治疗作用,包括抗炎,抗氧化剂和肝脏保护性.还研究亚马罗尼琴在传统医学中的作用,特别是在消化健康和食欲刺激方面的作用.其苦恼是由于该植物家族的许多化合物所特有的甲状腺体结构.由于其复杂的结构和生物活性,亚马龙素是正在进行的研究的课题,特别是在夏洛尼西和天然产品化学方面,以探讨其在健康和健康方面的潜在应用.
- 英文名称(2S,3R,4S,5S,6R)-4,5-Dihydroxy-6-(Hydroxymethyl)-2-(((3S,4R,4As)-8-Oxo-4-Vinyl-3,4,4A,5,6,8-Hexahydropyrano[3,4-C]Pyran-3-yl)Oxy)Tetrahydro-2H-Pyran-3-Yl 3,3',5-Trihydroxy-[1,1'-Biphenyl]-2-Carboxylate
- 中文名称苦龙胆脂甙
- IUPAC名称(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-2-(((4aS,5R,6S)-1-oxo-5-vinyl-4,4a,5,6-tetrahydro-1H,3H-pyrano[3,4-c]pyran-6-yl)oxy)tetrahydro-2H-pyran-3-yl 3,3',5-trihydroxy-[1,1'-biphenyl]-2-carboxylate
- 其它别名1H,3H-Pyrano(3,4-C)Pyran-1-One, 5-Ethenyl-4,4A,5,6-Tetrahydro-6-((2-O-((3,3',5-Trihydroxy(1,1'-Biphenyl)-2-yl)Carbonyl)-Beta-D-Glucopyranosyl)Oxy)-, (4As,5R,6S)-; Amarogentin [mi]; 5L82Gt5I0W
- CAS编号21018-84-8
- MFCD编号:MFCD06656289
- EINECS号:639-021-0
- FDA UNII编号:5L82GT5I0W
- 分子式:C29H30O13分子量:586.55
- 产品CID: 1087120
- 产品分类生物化工 → 提取物 → 植物提取物
物理性质
MSDS等安全信息
欧盟法规
C&L通报合成工艺路线路线简述
专利信息
专利号:US-12129222-B2
优先权日:2016-08-11
标题:Production of bitter principle derivatives
发明人：WYRWA RALF; RODE CLAUDIA; SEEMANN THOMAS; MEINEL LORENZ; RITZER JENNIFER; SCHNABELRAUCH MATTHIAS
权利人:UNIV WUERZBURG J MAXIMILIANS; JULIUS MAXIMILIANS UNIV
摘要:It is an object of the present invention to introduce carboxylic acid-functionalities suitable for coupling into the denatonium structure by means of simple synthesis, namely the synthesis of bitter principle derivatives based on the denatonium structure according to formula 1:For example, according to the invention, lidocaine derivatives may be reacted with carboxylated benzyl halogenides. The carboxylated denatonium derivatives of the present invention are especially applied in medicine, biology, medical engineering as well as cosmetics, the pharmaceutical, chemical, and foodstuff industry.
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Patel K, Kumar V, Verma A, Rahman M, Patel DK. Amarogentin as Topical Anticancer and Anti-Infective Potential: Scope of Lipid Based Vesicular in its Effective Delivery. Recent Pat Antiinfect Drug Discov. 2019;14(1):7-15. doi: 10.2174/1574891X13666180913154355.
2020:3184019. doi: 10.1155/2020/3184019.
3: Niu HS, Chao PC, Ku PM, Niu CS, Lee KS, Cheng JT. Amarogentin ameliorates diabetic disorders in animal models. Naunyn Schmiedebergs Arch Pharmacol. 2016 Nov;389(11):1215-1223. doi: 10.1007/s00210-016-1283-x. Epub 2016 Aug 3. 19(2):452-457. doi: 10.5114/aoms.2019.89652.
合成参考文献
参考文献:10.1155/2014/728019
摘要:Yen T, Lu W, Lien L, Thomas PA, Lee T, Chiu H, Sheu J, Lin K. Amarogentin, a Secoiridoid Glycoside, Abrogates Platelet Activation through PLCγ2-PKC and MAPK Pathways. BioMed Research International. 2014;2014():1–9. doi: 10.1155/2014/728019.
📝 需求与反馈
尽可能描述清楚需求与问题信息
