CAS: 20562-02-1; (2S,3R,4S,5S,6R)-2-(((2R,3S,4S,5R,6R)-3-Hydroxy-2-(Hydroxymethyl)-6-(((4S,6Ar,6Bs,8As,8Br,9S,9Ar,12S,14As,15As,15Bs)-6A,8A,9,12-Tetramethyl-3,4,5,6,6A,6B,7,8,8A,8B,9,9A,10,11,12,13,14A,15,15A,15B-Icosahydro-1H-Naphtho[2',1':4,5]Indeno[1,2-B]Indolizin-4-yl)Oxy)-5-(((2R,3R,4R,5R,6S)-3,4,5-Trihydroxy-6-Methyltetrahydro-2H-Pyran-2-yl)Oxy)Tetrahydro-2H-Pyran-4-yl)Oxy)-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-3,4,5-Triol

专利信息

专利号:US-9783838-B2
优先权日:2011-11-07
标 题 :PmST3 enzyme for chemoenzymatic synthesis of alpha-2-3-sialosides
发明人：CHEN XI; THON VIREAK; YU HAI
权利人:UNIV CALIFORNIA
摘要:The present invention provides novel methods for preparing glycosylated molecules such as oligosaccharides, glycolipids, and glycoproteins/peptides. Novel sialyltransferases are also disclosed. The method includes forming a reaction mixture containing an acceptor molecule, a donor substrate having a sugar moiety and a nucleotide, and a sialyltransferase selected from PmST3 (SEQ ID NO:7) and certain variants thereof. The reaction mixture is formed under conditions sufficient to transfer the sugar moiety from the donor substrate to the acceptor molecule, thereby forming the glycosylated molecule. In some embodiments, the acceptor molecule is selected from a natural product, an oligosaccharide, a glycoprotein, and a glycolipid. In some embodiments, the donor substrate is formed via conversion of a suitable hexosamine derivative to a cytidine 5′-monophosphate(CMP)-sialic acid in a one-pot reaction mixture containing asialic acid aldolase and a CMP-sialic acid synthetase.

专利号:CN-110526961-B
优先权日:2019-09-09
标题 :Application of transcription factor participating in regulation and control of synthesis of tomato steroid alkaloid

专利号:YU-61594-A
优先权日:1994-10-21
标 题:OBTAINING NEW SOLADIN AND 16-DEHYDROPREGNAN-20-O DERIVATIVES FOR THE SYNTHESIS OF STEROID HORMONES

专利号:WO-2013070677-A1
优先权日:2011-11-07
标 题 :PmST3 ENZYME FOR CHEMOENZYMATIC SYNTHESIS OF ALPHA-2-3-SIALOSIDES

专利号:RU-2141963-C1
优先权日:1995-12-21
标题 :Glycosides, methods for synthesis thereof, method of increasing biological accessibility of biologically-active material, and method of affecting living organism by biologically-active material

专利号:CN-110526961-A
优先权日:2019-09-09
标 题 :Application of transcription factors involved in regulation of tomato steroidal alkaloid synthesis