CAS: 1493-03-4; Difluoroiodomethane

上下游产品

CAS号58201-66-4 (溴二氟甲基)三苯基溴化膦 | CAS号354-08-5 二氟溴乙酸 | CAS号19740-21-7 Kalium-chlordif... | CAS号1717-59-5 2,2-二氟-2-(氟磺酰基)乙酸 | CAS号677-67-8 2-(氟磺酰基)二氟乙酰基氟化物 | CAS号87189-16-0 2-溴-2,2-二氟乙酸钾 | CAS号76-04-0 一氯二氟乙酸 | CAS号680-15-9 氟磺酰二氟乙酸甲酯 | CAS号75-47-8 三碘甲烷 | CAS号335-06-8 trifluoro(trifl... | CAS号359-35-3 1,1,2,2-四氟乙烷 | CAS号24708-53-0 N,N,1,1-tetrafl... | CAS号75-10-5 二氟甲烷 | CAS号1512-27-2 bromofluoroiodo... | CAS号75-03-6 碘乙烷 | CAS号1214329-62-0 4-氟-2-二氟甲氧基硝基苯 | CAS号1131614-23-7 4-(二氟甲氧基)-3-碘苯甲酸甲酯

📜二氟甲烷磺酰氯置于magnesium Iodide体系中,用 乙腈 用作溶剂,化学反应 2.0H,以79%的收率获得二氟碘甲烷
参考文献:氟烷基碘代物的制备方法
标题:氟烷基碘代物的制备方法
摘要:本发明公开了一种氟烷基碘代物的制备方法,具体公开了式(I)所示的氟烷基碘代物的制备方法,其包括以下步骤:第一溶剂中,将式(II)所示化合物与碘化物进行如下所示的碘代反应,即可.本发明方法使用的原料易得,且价格较为廉价.此外,该方法转化率及产率高,官能团容忍度较高.

专利信息

专利号:US-2015239796-A1
优先权日:2014-02-19
标题:One pot synthesis of 18f labeledtrifluoromethylated compounds with difluoro(iodo)methane
发明人：RüHL THOMAS; RISS PATRICK; RAFIQUE WAQAS
权利人:UNIV OSLO
摘要:The present invention relates to compositions and methods for the synthesis of 18 F labeled compounds. In particular, the present invention relates to a copper (I) mediated one pot method for 18 F-trifluoromethylation of aromatic- or heteroaromatic halides with difluoro(iodo)methane (e.g., for use at PET imaging agents).

专利号:US-2022056025-A1
优先权日:2018-09-25
标 题:Synthesis of pyrido[2,3-d]pyrimidin-7(8h)-ones
发明人：BROWN ADAM ROSS; DESROSIERS JEAN-NICOLAS; DUAN SHENGQUAN; HAWKINS JOEL MICHAEL; HAYWARD CHERYL MYERS; MALONEY MARK THOMAS; MONFETTE SEBASTIEN; PERFECT HAHDI HAKIMIOUN; WIDLICKA DANIEL WILLIAM
权利人:PFIZER
摘要:This invention relates to novel methods to prepare substituted pyrido[2,3-d]pyrimidin-7(8H)-ones, and salts and stereoisomers thereof, as well as intermediates useful for the preparation of such compounds.

专利号:US-7119232-B2
优先权日:2004-03-26
标题 :Nucleophilic substitution reactions of difluorormethyl phenyl sulfone with alkyl halides leading to the facile synthesis of terminal 1,1-difluoro-1-alkenes and difluoromethylalkanes
发明人：PRAKASH G K SURYA; HU JINBO; OLAH GEORGE A; WANG YING
权利人:UNIV SOUTHERN CALIFORNIA
摘要:(Benzenesulfonyl)difluoromethyl anion, in situ generated from difluoromethyl phenyl sulfone and a base, was found to easily undergo nucleophilic substitution reactions (S N 2) with primary alkyl halides, elemental halogens, and perfluoroalkyl halides with good selectivity. The formed (benzenesufonyl)difluoromethylalkanes are useful intermediates for the facile preparation of 1,1-difluoro-1-alkenes and difluoromethylalkanes. Thus, difluoromethyl phenyl sulfone acts as both “CF 2 ╠†and “CF 2 H − †synthons

专利号:AR-116504-A1
优先权日:2018-09-25
标 题:SYNTHESIS OF PIRIDO [2,3-d] PYRIMIDIN-7 (8H) ONAS, INTERMEDIARY COMPOUNDS FOR SUCH SYNTHESIS AND PREPARATION OF THE SAME

专利号:US-9006231-B2
优先权日:2008-03-03
标 题:Cephalotaxus esters, methods of synthesis, and uses thereof
发明人：GIN DAVID Y; WILMOT JEREMY; DJABALLAH HAKIM
权利人:SLOAN KETTERING INST CANCER
摘要:The present invention provides novel cephalotaxus esters, syntheses thereof, and intermediates thereto. The invention also provides pharmaceutical compositions comprising a compound of the present invention and methods of using said compounds or compositions in the treatment of proliferative diseases (e.g., benign neoplasm, cancer, inflammatory disease, autoimmune disease, diabetic retinopathy) and infectious disease. The invention further provides methods of using said compounds or compositions in the treatment of multidrug resistant cancer.

专利号:US-2006052643-A1
优先权日:2004-03-26
标题:Nucleophilic substitution reactions of difluorormethyl phenyl sulfone with alkyl halides leading to the facile synthesis of terminal 1,1-difluoro-1-alkenes and difluoromethylalkanes