专利号:US-2025229247-A1 优先权日:2024-01-11 标题:Next-Generation Fluidics Technology For Efficient Autonomous Synthesis of Colloidal Nanoparticles 发明人:ZHANG YUGANG; LU FANG; GANG OLEG 权利人:BROOKHAVEN SCIENCE ASS LLC 摘要:Various examples are provided related to nanoparticle synthesis. In one example, a system includes a self-driven fluidics platform including a chemical handling module and a reactor module. A mixer can form an initial mixture and deliver it through the ejector port as part of a segmented flow. The reactor module can control environmental conditions during synthesis of a nanoparticle. A flow reactor includes a channel that allows the segmented flow to move through the flow reactor via the channel and at least one observation window to enable real-time characterization of nanoparticles in individual droplets in the segmented flow through the flow reactor. In another example, a method comprises forming and flowing a segmented flow of droplets into a reactor, measuring a target property of nanoparticles in droplets in the segmented flow, and adjusting formation of droplets added to the segmented flow based upon the measured target property.
专利号:US-2022218741-A1 优先权日:2019-05-31 标 题 :Cell-Mediated Synthesis of Noble Metal Oxide Nanoparticles and Biomedical Applications Thereof 发明人:CRUZ DAVID MEDINA; CHEN JUNJIANG; WEBSTER THOMAS J 权利人:UNIV NORTHEASTERN 摘要:Human dermal fibroblasts (HDF) and melanoma (MEL) cells are used herein for synthesis of metal nanoparticles. For example, synthesis of nanoparticles of gold (Au), palladium (Pd), platinum (Pt), and bimetallic formulations of gold-palladium (AuPd) and gold-platinum (AuPt) is demonstrated with HDF and MEL using a straightforward, eco-friendly and cost-effective approach. The nanostructures are purified and used in biomedical tests, which show selective behavior. The production of nanoparticles allows for stopping of the growth of cancer cells and the ability of new healthy cells to grow on top. The production of nanoparticles with the cells allows for an environmental-resistance behavior within the cells, showing the ability to stand for extreme environmental conditions.
专利号:US-8641798-B2 优先权日:2010-07-13 标 题 :One-step synthesis of monodisperse AU-CU nanocubes 发明人:HIGHT-WALKER ANGELA R; LIU YONGLIN 权利人:HIGHT-WALKER ANGELA R; LIU YONGLIN; US OF AMERICA AS REPRESENTED BY THE SECRETARY OF COMMERCE NIST 摘要:A one-step process for synthesizing gold-copper bimetallic nanocubes. The process comprises the step of simultaneously reducing a copper II salt and a gold halide by 1,2-hexadecanediol in diphenyl ether, and 1-dodecanethiol as well as surfactants 1-adamantanecarboxylic acid and 1-hexadecylamine. The copper II salt may be copper (II) acetylacetonate, copper chloride, copper sulfate, or copper phosphate. The gold halide may be chloroauric acid, gold chloride, gold bromide, or tetrabromoauric acid. The reduction may occur at a temperature between about 160 and 180 degrees Celsius. The copper II salt may be copper (II) acetylacetonate and the gold halide may be chloroauric acid.
专利号:WO-2022216234-A9 优先权日:2021-04-07 标题 :Feedback-controlled automated nanoparticle synthesis 发明人:LING XING YI; LEE YIH HONG 权利人:UNIV NANYANG TECH 摘要:Herein disclosed is a system operable to synthesize nanoparticles, which includes a robotic module comprising: a temperature controller; one or more dispensers operable to dispense different reagents; and an extraction device; a reaction vessel configured to receive the different reagents from the one or more dispensers to form a reaction mixture from which the nanoparticles are synthesized; and a process control module operably coupled to the robotic module and a spectroscopy module, wherein the process control module configures: the extraction device to withdraw a sample of the reaction mixture at an interval as the reaction mixture progresses and to transfer the sample into one or more cuvettes of the spectroscopy module, and the spectroscopy module to generate spectral data based on an optical property of the sample and from the spectral data identify a condition which serves as a feedback to the process control module to configure: the temperature controller to change or maintain temperature of the reaction mixture as the reaction mixture progresses, the one or more dispensers to change or maintain a frequency and/or time and/or an amount of each different reagent dispensed into the reaction mixture as the reaction mixture progresses, and the extraction device to change or maintain the interval for withdrawing further samples of the reaction mixture to provide the feedback continuously to have the process control module configure the temperature controller, the one or more dispensers, and the extraction device, in aforesaid manner until synthesis of the nanoparticles in the reaction mixture is completed. Also, herein discloses a method of synthesizing nanoparticles using the system.
专利号:US-11958866-B1 优先权日:2023-04-07 标题:Synthesis of thiazole derivatives 发明人:NOOR AWAL; KHAN EZZAT; KHAN UMAR ALI 权利人:UNIV KING FAISAL 摘要:A synthetic protocol to use a thiourea or urea compound and auric chloride as starting materials to obtain thiazole and benzothiazole derivatives. The synthesis can be conducted at room temperature and the final compound can result from cyclization of the thiourea or urea compound in the presence of an Au salt from the auric chloride.
专利号:US-8211205-B1 优先权日:2009-07-28 标题:Method of controlled synthesis of nanoparticles 发明人:DIDENKO YURI TROFIMOVICH; NI YUHUA 权利人:DIDENKO YURI TROFIMOVICH; NI YUHUA; UT DOTS INC 摘要:A method for the synthesis and manufacture of metal nanoparticles using metal inorganic salts. The method is simple and uses inexpensive chemicals. The procedure produces nanometals in 100% yields. Method is scalable and produces nanoparticles in unlimited quantities. In this method, a metal inorganic salt is dissolved in a reaction medium, comprised of a solvent and organic amine to create a metal/amine complex. A reducing agent, comprised of a solvent and Sodium Borohydride (NaBH 4 ), is then mixed with the metal/amine complex through titration or through a continuous flow process. The resulting nanoparticles are then precipitated through the addition of methanol and centrifugation and decanted. The decanted nanoparticles can then be suspended in a solvent for storage.
参考标题:Synthesis And Molecular Structure Of [au4Cl8], And The Isolation Of [pt(Co)Cl5] In Thionyl Chloride 作者:Daniela Belli Dell'Amico,Fausto Calderazzo,Fabio Marchetti,Stefano Merlino 摘要:A High-Yield Synthesis Of [au4Cl8] By Treatment Of [au2Cl6] With The Stoicheiometric Amount Of Co In Cocl2 Is Described. The Crystal And Molecular Structure Of The Tetranuclear Compound Has Been Solved By X-Ray Diffraction Methods. It Is Triclinic, Space Group P, With A = 7.015(4), B= 6.830(2), C= 6.684(4)å, α= 94.4(1), β= 107.5(1), γ= 88.4(1)°, And Z= 1, And Has Been Refined To R= 0.11 For 989 ' Observed
合成参考文献
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