CAS: 1323-03-1; Tetradecyl 2-Hydroxypropanoate

相似化合物

34451-19-9 35274-05-6 6283-92-7

📜乳酸,十四醇置于对甲苯磺酸,硫酸体系中,用 二氯甲烷 用作溶剂,化学反应 7.0H,反应生成Dl-乳酸十四酯
参考文献:某些基于乳酸的阴离子表面活性剂的合成及表面和生物学性质的评估
标题:某些基于乳酸的阴离子表面活性剂的合成及表面和生物学性质的评估
摘要:在本研究中,合成了11种基于乳酸的阴离子表面活性剂,并对其表面和生物学活性进行了评估.合成涉及乳酸与一系列链长以及支链和不饱和度不同的脂肪醇的酯化反应.通过用氯磺酸处理将所得的酯磺化,然后用naoh水溶液形成盐.使用表面张力测定法测定所有合成的表面活性剂的表面性质.合成的表面活性剂显示出较低的临界胶束浓度(cmc)值,并且随着烷基链长度的增加而呈下降趋势.与具有相同碳原子数的线性对应物相比,烷基支化还导致cmc值的轻微变化,尽管观测到这种减少或增加取决于分支的位置和数量.一些合成的表面活性剂对被测微生物菌株和细胞系表现出非常好的抗微生物和抗癌活性.
Doi:10.1007/s11743-015-1774-7

专利信息

专利号:US-9597327-B2
优先权日:2005-05-25
标 题:Synthesis of (R)-N-methylnaltrexone
发明人：DOSHAN HAROLD D; PEREZ JULIO
权利人:PROGENICS PHARM INC
摘要:This invention relates to stereoselective synthesis of R-MNTX and intermediates thereof, pharmaceutical preparations comprising R-MNTX or intermediates thereof and methods for their use.

专利号:US-7722904-B2
优先权日:2007-11-01
标 题 :Compositions and methods for stimulating synthesis of pro-collagen or collagen and hyaluronic acid
发明人：SCHNEIDER LOUISE M; PUSATERI DONALD J; LA TOM Q
权利人:ACCESS BUSINESS GROUP INT LLC
摘要:A method for improving the appearance, texture and/or moisture of skin comprising administering a composition comprising Chia Seed oil, Opuntia ficus Indica extract, or both to stimulate collagen or hyaluronic acid synthesis, or decrease Interleukin-1b synthesis, in the skin.

专利号:US-9757317-B2
优先权日:2014-09-12
标题 :Cosmetic compositions and methods for inhibiting melanin synthesis
发明人：LAUGHLIN II LEO TIMOTHY; HAKOZAKI TOMOHIRO; GUPTA SHIKHAR
权利人:PROCTER & GAMBLE
摘要:A cosmetic composition suitable for topical application, for example, is provided. In some examples, the cosmetic composition may include bisabolol, undecylenoyl phenylalanine and/or hexyldecanol, and a material selected from the group consisting of ethyl palmitate, stearyl alcohol, bis (2-ethylhexyl) adipate, bis (2-ethylhexyl) maleate, 5-pentadecanol, 1-stearoyl-rac-glycerol, bis (2-ethylhexyl) sebacate, and mixtures thereof. A method of reducing the synthesis of melanin by using the cosmetic compositions is also disclosed herein.

专利号:US-9498420-B2
优先权日:2013-05-01
标 题:Cosmetic compositions and methods for inhibiting melanin synthesis
发明人：LAUGHLIN II LEO TIMOTHY; HAKOZAKI TOMOHIRO; TANAKA SHUHEI
权利人:PROCTER & GAMBLE
摘要:A cosmetic composition suitable for topical application, for example, is provided. In some examples, the cosmetic composition may include batyl alcohol, undecylenoyl phenylalanine, hexyldecanol, and bisabolol. A method of reducing the synthesis of melanin by using the cosmetic compositions is also disclosed herein.

专利号:US-2007082039-A1
优先权日:2004-10-18
标题 :Synthesis of fatty alcohol esters of alpha-hydroxy carboxylic acids, the use of the same as percutaneous permeation enhancers, and topical gels for the transdermal delivery of steroids
发明人：JONES GERALD S JR; ST LAURENT JOSEPH P; GOODRICH SCOTT A
权利人:JONES GERALD S JR; ST LAURENT JOSEPH P; GOODRICH SCOTT A
摘要:The present invention provides a novel approach for the preparation of fatty alcohol esters of α-hydroxy carboxylic acids. The present invention also provides a novel topical gel for the transdermal delivery of steroids using the fatty alcohol esters as permeation enhancers.

专利号:US-10022366-B2
优先权日:2013-04-23
标 题:Extending and maintaining micropore viability of microneedle treated skin with lipid biosynthesis inhibitors for sustained drug delivery
发明人：STINCHCOMB AUDRA L; GHOSH PRIYANKA
权利人:STINCHCOMB AUDRA L; GHOSH PRIYANKA; UNIV MARYLAND; UNIV KENTUCKY RES FOUND
摘要:Microneedles and their use as a physical skin permeation enhancement technique facilitate drug delivery across the skin in therapeutically relevant concentrations. Micropores created in the skin by MNs reseal because of normal healing processes of the skin, thus limiting the duration of the drug delivery window. Pore lifetime enhancement strategies can increase effectiveness of MNs as a drug delivery mechanism by prolonging the delivery window. Fluvastatin (FLU) was used to enhance pore lifetime by inhibiting the synthesis of cholesterol, a major component of the stratum corneum lipids. The skin recovered within a 30-45-min time period following the removal of occlusion, and there was no significant irritation observed due to the treatment compared to the control sites. Thus, it can be concluded that localized skin treatment with FLU can be used to extend micropore lifetime and deliver drugs for up to 7 days across MN-treated skin.