专利号:US-2024024489-A1 优先权日:2020-11-20 标 题:Protected disaccharides, their process of preparation and their use in the synthesis of zwitterionic oligosaccharides, and conjugates thereof 发明人:MULARD LAURENCE; DHARA DEBASHIS; PFISTER HELENE; PAOLETTI JULIE; PHALIPON ARMELLE; GUERREIRO-INVERNO CATHERINE 权利人:PASTEUR INSTITUT 摘要:The present invention provides zwitterionic oligosaccharides, in particular fragments of the surface polysaccharides from Shigella sonnei and Shigella sonnei conjugates comprising them. The present invention also provides protected disaccharides, their process of preparation and their use in the synthesis of zwitterionic oligosaccharides, and conjugates thereof, the disaccharide repeating unit of Shigella sonnei being: (I)
专利号:US-2021206899-A1 优先权日:2020-09-14 标 题 :Synthesis of janus dendrimers 发明人:NAJAFI FAEZEH; Salami-Kalajahi Mehdi; ROGHANI-MAMAQANI HOSSEIN 权利人:NAJAFI FAEZEH; SALAMI KALAJAHI MEHDI; ROGHANI MAMAQANI HOSSEIN; SAHAND UNIV OF TECHNOLOGY 摘要:A method for synthesizing Janus dendrimers, including synthesizing a hydrophobized dendrimer by reacting a dendrimer with a carboxylic acid, forming a first dendron with a thiol group by splitting the hydrophobized dendrimer through breaking a disulfide bond of the core into thiol groups, forming a reactive dendron by reacting the thiol group of the first dendron with methyl acrylate and a radical initiator, synthesizing a primary core by reacting the reactive dendron with ethylenediamine (EDA), and forming a Janus dendrimer by synthesizing a second dendron on the primary core. The hydrophobized dendrimer includes a core containing a disulfide bond.
专利号:US-5738855-A 优先权日:1994-10-17 标题:Synthesis of typhoid fever vaccine from a plant or fruit polysaccharide 发明人:SZU SHOUSUN CHEN; BYSTRICKY SLAVOMIR 权利人:US ARMY 摘要:The present invention is a modified plant, fruit or synthetic oligo- or polysaccharide which has been structurally altered so as to render the modified saccharide antigenically similar to the Vi of Salmonella typhi. The modified saccharide may be conjugated to a carrier to form a conjugate that is immunogenic against S. typhi. Antibodies produced in response to the immunogenic conjugate are protective against typhoid fever. Methods are provided for making the modified saccharide and the immunogenic conjugate.
专利号:WO-2025038471-A1 优先权日:2023-08-11 标 题:Flow synthesis of organic adsorbents and a flow photo-reactor for the adsorption and degradation of contaminants in water sources 发明人:KHALIL SAFIYA; VERDUZCO RAFAEL; ALAZMI ABDULLAH 权利人:UNIV RICE WILLIAM M 摘要:A method of making a covalent organic framework includes continuously feeding a first precursor and a second precursor to a flow reactor; heating, and mixing the first and second precursors; nucleating and growing the covalent organic framework; and continuously outputting the covalent organic framework from the third section of the flow reactor. A photo-reactor for treating contaminated water includes: a light source; an enclosed channel around the light source; a cover comprising one or more lights illuminating the enclosed channel; and a covalent organic framework cased within the enclosed channel, where the covalent organic framework is photo-catalytically active for degrading a contaminant in the contaminated water so as to produce treated water. A method of treating contaminated water includes feeding the contaminated water to the photo-reactor and contacting the contaminated water with the covalent organic framework.
专利号:US-2009111737-A1 优先权日:1999-05-24 标题:Novel antibacterial agents 发明人:CHRISTENSEN BURTON G; MORAN EDMUND J; GRIFFIN JOHN H; JUDICE J KEVIN; MU YONGQI; PACE JOHN L; MAMMEN MATHAI; AGGEN JAMES 权利人:CHRISTENSEN BURTON G; MORAN EDMUND J; GRIFFIN JOHN H; JUDICE J KEVIN; MU YONGQI; PACE JOHN L; MAMMEN MATHAI; AGGEN JAMES 摘要:This invention relates to novel multibinding compounds (agents) that are antibacterial agents. The multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands in their monovalent (i.e., unlinked) state have the ability to bind to a an enzyme involved in cell wall biosynthesis and metabolism, a precursor used in the synthesis of the bacterial cell wall and/or the bacterial cell surface thereby interfere with the synthesis and/or metabolism of the cell wall. In particular the multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands hasn a ligand domain capable of binding to penicillin binding proteins, a transpeptidase enzyme, a substrate of a transpeptidase enzyme, a beta-lactamase enzyme, pencillinase enzyme, cephalosporinase enzyme, a transglycoslase enzyme, or a transglycosylase enzyme substrate; Preferably, the ligands are selected from the beta lactam or glycopeptide class of antibacterial agents.
专利号:US-2024229131-A1 优先权日:2022-12-22 标 题 :Transition-metal catalyst compositions and methods for sequencing by synthesis 发明人:MARIANI ANGELICA; BEECH TIMOTHY; FRANCAIS ANTOINE; PANIGRAHI ADYASHA; HATTINGH KATHRYN; CRESSINA ELENA 权利人:ILLUMINA INC 摘要:The present application relates to compositions and methods for sequencing by synthesis. A blocking group of a nucleotide may be removed by a transition metal catalyst, the transition metal catalyst activated by a non-reducing ligand and a reducing agent.
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