CAS: 110567-22-1; (1S,2R,3S,5R)-3-(Benzyloxy)-2-((Benzyloxy)Methyl)-6-Oxabicyclo[3.1.0]Hexane

相似化合物

873298-16-9 701278-59-3 2165482-46-0

上下游产品

benzyl bromide hexan-3-ol(2R,3S)-2-benzyloxymethyl-6-oxabicyclo3.1.0hexan-3-ol Benzyloxymethyl chloride 5-(benzyloxymethyl)cyclopentadiene (1S,2S,3S,5S)-5-[2-Amino-6-(2-methoxy-ethoxy)-purin-9-yl]-3-benzyloxy-2-benzyloxymethyl-cyclopentanol (1S,2S,3S,5S)-5-azido-3-(benzyloxy)-2-(benzyloxymethyl)cyclopentanol (1R,2R,3R,4S)-2-Azido-4-benzyloxy-3-benzyloxymethyl-cyclopentanol [1S-(1α,2β,3α,4β)]-1-[2-Hydroxy-4-(phenyl-methoxy)-3-[(phenylmethoxy)methyl]cyclopentyl]-2,4(1H,3H)-pyrimidinedione

(1S,2R)-1-Benzyloxy-2-Benzyloxymethylcyclopent-3-Ene置于双氧水体系中,用 二氯甲烷 用作溶剂,化学反应 6.0H,以95%的收率获得(1S,2R,3S,5R)-3-(苄氧基)-2-[(苄氧基)甲基]-6-氧杂二环[3.1.0]己烷
参考文献:恩替卡韦中间体的制备方法
标题:恩替卡韦中间体的制备方法
摘要:本发明提供了一种恩替卡韦中间体的制备方法,具体涉及制备(1S‑(1α,2α,3β,5α)‑2‑((苯甲氧基)甲基)‑6‑氧杂二环[3.1.0]己‑3‑醇和氧杂二环化合物(Nt02)的制备方法,本发明提供了一种全新的制备路线和反应工艺条件,操作安全性高,方法简单,产品收率显著提供,非常适合工业化生产应用.

专利信息

专利号:US-2011245484-A1
优先权日:2010-03-31
标 题 :Stereoselective synthesis of phosphorus containing actives

专利号:EP-2752422-A1
优先权日:2010-03-31
标 题 :Stereoselective synthesis of phosphorus containing actives

专利号:EP-2752422-B1
优先权日:2010-03-31
标题:Stereoselective synthesis of phosphorus containing actives

专利号:EP-2552931-B1
优先权日:2010-03-31
标题:Stereoselective synthesis of phosphorus containing actives

专利号:US-8859756-B2
优先权日:2010-03-31
标 题 :Stereoselective synthesis of phosphorus containing actives
发明人：ROSS BRUCE S; SOFIA MICHAEL JOSEPH; PAMULAPATI GANAPATI REDDY; RACHAKONDA SUGUNA; ZHANG HAI-REN
权利人:ROSS BRUCE S; SOFIA MICHAEL JOSEPH; PAMULAPATI GANAPATI REDDY; RACHAKONDA SUGUNA; ZHANG HAI-REN; GILEAD PHARMASSET LLC
摘要:Disclosed herein are phosphorus-containing actives, their use as actives for treating diseases, and a stereoselective process for preparing the same. Also disclosed herein are useful synthetic intermediates and processes for preparing the same.