CAS: 96516-31-3; 2-Chloro-3-Fluorobenzaldehyde

该化合物是一种氟化和氯化苯丁二烯衍生物,用作有机合成的多用途中间体,其主要优点包括:由于反应性甲醛和卤素替代成分,该化合物在制备药品,农用化学品和特殊化学品方面的作用有利于进一步实现功能化;该化合物的电子提炼特性增强了其在交叉反应和核生殖替代中的效用;在标准条件下,该化合物具有高度纯度和稳定性,适合精确的合成应用;氯和氟组的存在允许有选择的修改,使复杂的化学工艺中能够定制分子设计.

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CAS号96516-32-4 2-氯-3-氟苄醇 | CAS号102940-86-3 2-氯-3-氟苯甲酸 | CAS号72235-54-2 2-氯-3-氟苯甲胺

合成工艺路线路线简述

  • 6334-18-5 = 96516-31-3
    反应条件:1.1 Reagents: Potassium Fluoride Catalysts: Tetraphenylphosphonium Bromide,Tetraspiro[21,22,23,24-Tetraoxapentacyclo[16.2.1.13,6.18,11.113,16]Tetracosa-3,5... Solvents: 3,4-Dichlorotoluene; 2 H,213 °C
    标题:Halogen-Exchange Fluorination Of Chlorinated Benzaldehydes And Diphenyl Ketones Promoted By Microwave
    作者:Liang,Zhengyong; Lu,Chun-Xu
    参考文献:Advanced Materials Research (Durnten-Zurich 日期:2011 卷标:266 页码:292-295]

    = 96516-31-3 [标题:Reaction Conditions
    标题:Preparation Of Dihydropyrimidine Derivatives And Uses Thereof In The Treatment Of Hbv Infection Or Of Hbv-Induced Diseases
    参考文献:World Intellectual Property Organization]

    102940-86-3 = 96516-31-3
    反应条件:1.1 Reagents: (T-4)-Trihydro(Tetrahydrofuran)Boron Solvents: Tetrahydrofuran; 0 °C; Overnight,Reflux; Cooled1.2 Reagents: Hydrochloric Acid Solvents: Ethyl Acetate,Water1.3 Reagents: Dimethyl Sulfoxide,Oxalyl Chloride Solvents: Dichloromethane; 5 Min,-78 °C1.4 Solvents: Dichloromethane; -78 °C; 1 H,-40 °C1.5 Reagents: Triethylamine; -40 °C -> Rt
    标题:Discovery Of A New 2-Aminobenzhydrol Template For Highly Potent Squalene Synthase Inhibitors
    作者:Ichikawa,Masanori; Yokomizo,Aki; Itoh,Masao; Usui,Hiroyuki; Shimizu,Hironari; Et Al
    参考文献:Bioorganic & Medicinal Chemistry 日期:2011 卷标:19(6) 页码:1930-1949]

    116850-28-3 = 96516-31-3
    反应条件:1.1 Reagents: Chromium Trioxide
    标题:Synthesis And Antihypertensive Activity Of 1,4-Dihydropyridine Derivatives With A 4-(Disubstituted Phenyl) Ring And An Aminoalkyl Ester Group: Highly Potent And Long-Lasting Calcium Antagonists
    作者:Kanno,Hideo; Yamaguchi,Hisao; Okamiya,Yoshiaki; Sunakawa,Kiyotaka; Takeshita,Toru; Et Al
    参考文献:Chemical & Pharmaceutical Bulletin 日期:1992 卷标:40(8) 页码:2049-54]

    = 96516-31-3 [标题:Reaction Conditions
    标题:Design,Synthesis,And Evaluation Of Tetrahydropyrrolo[1,2-C]Pyrimidines As Capsid Assembly Inhibitors For Hbv Treatment
    作者:Li,Xiaolin; Zhou,Kai; He,Haiying; Zhou,Qiong; Sun,Ya; Et Al
    参考文献:Acs Medicinal Chemistry Letters 日期:2017 卷标:8(9) 页码:969-974]

    = 96516-31-3 [标题:Reaction Conditions
    标题:Discovery Of A New 2-Aminobenzhydrol Template For Highly Potent Squalene Synthase Inhibitors [erratum To Document Cited In Ca154:564965]
    作者:Ichikawa,Masanori; Yokomizo,Aki; Itoh,Masao; Usui,Hiroyuki; Shimizu,Hironari; Et Al
    参考文献:Bioorganic & Medicinal Chemistry 日期:2014 卷标:22(11)]

    = 96516-31-3 [标题:Reaction Conditions
    标题:1,4-Dihydropyridines
    参考文献:Japan]

    = 96516-31-3 [标题:Reaction Conditions
    标题:Dihydropyridinedicarboxylate Cardiovascular Agents
    参考文献:European Patent Organization]

    = 96516-31-3 [标题:Reaction Conditions
    标题:Halonitrobenzaldehyde Derivatives
    参考文献:Japan]

    = 96516-31-3 [标题:Reaction Conditions
    标题:1,4-Dihydropyridine Derivatives,And Their Pharmaceutical Use
    参考文献:European Patent Organization
📜2-氯-3-氟苯甲酸置于硼烷四氢呋喃络合物,草酰氯,二甲基亚砜体系中,用 四氢呋喃,二氯甲烷 作为反应溶剂,化学反应 1.0H,反应生成 2-氯-3-氟苯甲醛
参考文献:发现了一种新的2-氨基苯甲酰模板用于高效角鲨烯合酶抑制剂
标题:发现了一种新的2-氨基苯甲酰模板用于高效角鲨烯合酶抑制剂
摘要:为了获得小的和有效的角鲨烯合酶抑制剂,设计了一种灵活的2-氨基苯并氢开放形式结构,并显示了与4,1-苯并恶唑啉化合物相当的有效抑制活性.进一步的化学修饰导致发现了具有强鲨烯合酶抑制活性的新型模板,并且揭示了其基本的结构-活性关系.与角鲨烯合酶活性位点结合的化合物12的x射线晶体学数据提供了对该替代模板的结合模式的重要见解,该替代模板形成了具有分子内氢键的11元环构象.
DOI:10.1016/j.Bmc.2011.01.065

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专利信息


专利号:US-2022356139-A1
优先权日:2019-09-03
标 题:Synthesis of deuterated aldehydes
发明人：WANG WEI
权利人:ARIZONA BOARD OF REGENTS ON BEHALF OF ATHE UNIV OF ARIZONA
摘要:Described are methods for preparing a deuterated aldehyde using N-heterocyclic carbene catalysts in a solvent comprising D 2 O. The methods may be used to convert a wide variety of aldehydes (e.g., aryl, alkyl, or alkenyl aldehydes) to C-1 deuterated aldehydes under mild reaction conditions without functionality manipulation.

专利号:WO-2021045879-A1
优先权日:2019-09-03
标 题 :Synthesis of deuterated aldehydes

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合成参考文献

参考DOI号:10.1016/j.bmc.2011.01.065
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