CAS: 800402-12-4; 2-Chloro-5-Iodo-4-Pyridinamine

该化合物是一种环有的杂交有机化合物,是一种六人组成的芳香环,内含一个氮原子;氯和碘替代物分别存在于2和5个位置上,有助于其独特的再活动及其在各个领域的潜在应用,包括药用化学和物质科学;该化合物一般在极有机溶剂中表现出中等溶性,由于卤素替代成分的缺水性,其溶性可能有限;其结构允许与生物目标发生潜在互动,使其对药物开发具有兴趣;此外,氨基层组在4个位置的存在增强了其再活动性,使进一步发挥功能;该化合物的特性,如熔点,沸点和光谱特性,可能因样品的具体条件和纯度而不同.

英文名称2-Chloro-5-Iodo-4-Pyridinamine
中文名称2-氯-5-碘-4-吡啶胺
IUPAC名称2-chloro-5-iodopyridin-4-amine
其它别名2-氯-4-氨基-5-碘吡啶; 4-Amino-5-Iodo-2-Chloropyridine
CAS编号800402-12-4
MFCD编号:MFCD09834661
EINECS号:804-398-4
分子式:C5H4ClIN2
分子量:254.46
产品CID: 1794416
产品分类有机原料→分子砌块→芳杂环类化合物→吡啶类化合物

相似结构搜索
InChIKey: DEJUUKULVAIMNF-UHFFFAOYSA-N
InChI=1S/C5H4ClIN2/c6-5-1-4(8)3(7)2-9-5/h1-2H,(H2,8,9)…
计算化学: 氢键受体数2.0氢键供体数1.0可旋转键数0.0

相似化合物

1235873-11-6 909036-46-0 1171919-00-8

MSDS等安全信息

GHS象形图
GHS符号GHS07 & GHS05;
注释: Exclamation mark & Corrosion
危险类别急性毒性类别4(经口)
严重眼损伤类别1
急性毒性类别4(吸入)
急性毒性类别4(经皮)
特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
警示词Danger(危险)
危险描述H302 |吞咽有害.
H318 |造成严重眼损伤.
H332 |吸入有害.
H312 |皮肤接触有害.
H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
防范说明P264-P270-P280-P330-P501
危险等级8
UN编号1759.0
危险品标志Xi
包装等级Ⅲ
安全声明26-39
危险类别码22-41
WGK Germany3

欧盟法规

C&L通报

上下游产品

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合成工艺路线路线简述

14432-12-3 = 800402-12-4 + 909036-46-0 + 1171919-00-8
反应条件:1.1 Reagents: Potassium Acetate,Iodine Chloride Solvents: Water; 4 D,Ph 5.5,75 °C1.2 Reagents: Sodium Carbonate Solvents: Water; Ph 7 - 8,Rt1.3 Reagents: Sodium Thiosulfate Solvents: Water; Rt
标题:Palladium-Catalyzed Synthesis Of 2,3-Disubstituted 5-Azaindoles Via Heteroannulation Reaction And Of 2-Substituted 5-Azaindoles Through Domino Sila-Sonogashira/5-Endo Cyclization
作者:Livecchi,Marion; Calvet,Geraldine; Schmidt,Frederic
参考文献:Journal Of Organic Chemistry 日期:2012 卷标:77(11) 页码:5006-5016]

14432-12-3 = 800402-12-4
反应条件:1.1 Reagents: N-Iodosuccinimide Solvents: Acetonitrile; Overnight,82 °C
标题:The Synthesis Of 3,3-Dimethyl Aza- And Diazaindolines Using A Palladium-Catalysed Intramolecular Reductive Cyclisation
作者:Day,James E. H.; Frederickson,Martyn; Hogg,Colin; Johnson,Christopher N.; Meek,Alistair; Et Al
参考文献:Synlett 日期:2015 卷标:26(18) 页码:2570-2574]

14432-12-3 = 800402-12-4 + 909036-46-0
反应条件:1.1 Reagents: Potassium Acetate,Iodine Chloride Solvents: Acetic Acid; 60 - 70 °C
标题:Potent 4-Amino-5-Azaindole Factor Viia Inhibitors
作者:Hu,Huiyong; Kolesnikov,Aleksandr; Riggs,Jennifer R.; Wesson,Kieron E.; Stephens,Robin; Et Al
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14432-12-3 = 800402-12-4 + 909036-46-0 + 1171919-00-8
反应条件:1.1 Reagents: Potassium Acetate,Iodine Chloride Solvents: Acetic Acid; 4 H,Rt -> 70 °C1.2 Reagents: Sodium Bicarbonate Solvents: Water; Neutralized
标题:Synthesis,Crystal Structure,Molecular Docking And Antimicrobial Evaluation Of New Pyrrolo[3,2-C]Pyridine Derivatives
作者:Jose,Gilish; Suresha Kumara,T. H.; Nagendrappa,Gopalpur; Sowmya,H. B. V.; Jasinski,Jerry P.; Et Al
参考文献:Journal Of Molecular Structure 日期:2015 卷标:1081 页码:85-95]

14432-12-3 = 800402-12-4 + 909036-46-0 + 1171919-00-8
反应条件:1.1 Reagents: Potassium Acetate,Iodine Chloride Solvents: Acetic Acid; 4 H,Rt -> 70 °C1.2 Reagents: Sodium Bicarbonate Solvents: Water; Neutralized
标题:New Polyfunctional Imidazo[4,5-C]Pyridine Motifs: Synthesis,Crystal Studies,Docking Studies And Antimicrobial Evaluation
作者:Jose,Gilish; Suresha Kumara,T. H.; Nagendrappa,Gopalpur; Sowmya,H. B. V.; Jasinski,Jerry P.; Et Al
参考文献:European Journal Of Medicinal Chemistry 日期:2014 卷标:77 页码:288-297]

14432-12-3 = 800402-12-4 + 909036-46-0 + 1171919-00-8
反应条件:1.1 Reagents: Potassium Acetate,Iodine Chloride Solvents: Acetic Acid; 4 H,70 °C
标题:Synthesis,Molecular Docking,Antimycobacterial And Antimicrobial Evaluation Of New Pyrrolo[3,2-C]Pyridine Mannich Bases
作者:Jose,Gilish; Suresha Kumara,Tholappanavara H.; Sowmya,Haliwana B. V.; Sriram,Dharmarajan; Guru Row,Tayur N.; Et Al
参考文献:European Journal Of Medicinal Chemistry 日期:2017 卷标:131 页码:275-288]

14432-12-3 = 800402-12-4
反应条件:1.1 Reagents: Potassium Acetate,Iodine Chloride Solvents: Acetic Acid; 3 H,80 °C
标题:Discovery Of 3-Alkoxyamino-5-(Pyridin-2-Ylamino)Pyrazine-2-Carbonitriles As Selective,Orally Bioavailable Chk1 Inhibitors
作者:Lainchbury,Michael; Matthews,Thomas P.; Mchardy,Tatiana; Boxall,Kathy J.; Walton,Michael I.; Et Al
参考文献:Journal Of Medicinal Chemistry 日期:2012 卷标:55(22) 页码:10229-10240]

14432-12-3 = 800402-12-4
反应条件:1.1 Reagents: Potassium Acetate Solvents: Pentane; 5 H,70 °C; 70 °C -> Rt1.2 Reagents: Sodium Bicarbonate Solvents: Ethyl Acetate,Water; Rt
标题:Multiparameter Lead Optimization To Give An Oral Checkpoint Kinase 1 (Chk1) Inhibitor Clinical Candidate: (R)-5-((4-((Morpholin-2-Ylmethyl)Amino)-5-(Trifluoromethyl)Pyridin-2-Yl)Amino)Pyrazine-2-Carbonitrile (Cct245737)
作者:Osborne,James D.; Matthews,Thomas P.; Mchardy,Tatiana; Proisy,Nicolas; Cheung,Kwai-Ming J.; Et Al
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14432-12-3 = 800402-12-4
反应条件:1.1 Reagents: Iodine,Sulfuric Acid,Silver(2+) Salt (1:1) Solvents: Ethanol; 72 H,Rt
标题:Discovery And Optimization Of Indoles And 7-Azaindoles As Rho Kinase (Rock) Inhibitors (Part-I)
作者:Chowdhury,Sarwat; Sessions,E. Hampton; Pocas,Jennifer R.; Grant,Wayne; Schroeter,Thomas; Et Al
参考文献:Bioorganic & Medicinal Chemistry Letters 日期:2011 卷标:21(23) 页码:7107-7112

2-氯-4-氨基吡啶置于n-碘代丁二酰亚胺体系中,用乙腈作为反应溶剂,以36%的收率获得产物2-氯-5-碘-4-吡啶胺
参考文献:使用钯催化的分子内还原环化合成 3,3-二甲基氮杂和二氮杂二氢吲哚
标题:使用钯催化的分子内还原环化合成 3,3-二甲基氮杂和二氮杂二氢吲哚
摘要:一系列的氮杂二氢吲哚是通过使用卤化,用 3-溴-2-甲基丙烯烷基化和钯催化的还原环化从杂环胺三个步骤制备的.化学证明适用于多克规模的操作.
DOI:10.1055/s-0035-1560320

海关参考信息

2933310010-吡啶
2939800000-其他生物碱
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:WO-2011050245-A1
优先权日:2009-10-23
标题:Bicyclic heteroaryls as kinase inhibitors
发明人：FENG YANGBO; CHEN YEN TING; SESSIONS HAMPTON; MISHRA JITENDRA K; CHOWDHURY SARWAT; YIN YAN; LOGRASSO PHILIP; LUO JUN-LI; BANNISTER THOMAS; SCHROETER THOMAS
权利人:FENG YANGBO; CHEN YEN TING; SESSIONS HAMPTON; MISHRA JITENDRA K; CHOWDHURY SARWAT; YIN YAN; LOGRASSO PHILIP; LUO JUN-LI; BANNISTER THOMAS; SCHROETER THOMAS
摘要:The invention is directed to heteroaryl compounds useful as inhibitors of various kinase enzymes. In various embodiments, the invention provides a heteroaryl compound having inhibitory bioactivity with respect to a Rho kinase, an AKT kinase, a p70S6K kinase, a LIM kinase, an IKK kinase, a Flt kinase, an Aurora kinase, or a Src kinase, or any combination thereof. Compounds of the invention include bicyclic heteroaryl compounds of formula (I), which can contain a bridging nitrogen atom at a ring junction. The invention further provides methods of synthesis of compounds of the invention, pharmaceutical compositions, pharmaceutical combinations, and methods of treatment of malconditions using compounds of the invention.