CAS: 79175-35-2; Magnesium,1,2-Dichlorobenzene-5-Ide,Bromide

该化合物是一种在有机合成中常用的灰色试剂,用于引入3,4-二氯苯基组;该溶剂的制造标准浓度(0.50M)为2-METHF,这是传统醚溶剂的绿色替代品,提供了更好的稳定性并减少了过氧化的形成;该试剂在核循环添加反应,混合过程以及合成药品或农用化学品方面特别宝贵;使用2-METHF在保持高再活性的同时加强了安全和储存寿命;建议在惰性大气下适当储存以保持其功效.

结构式图片

物理性质

MSDS等安全信息

欧盟法规

ECHA物质C&L通报

上下游产品

4-bromo-1,2-dichlorobenzene magnesium (1S,2S)-1-(3,4-Dichloro-phenyl)-2-imidazol-1-yl-cyclohexanol (1S,2R)-1-(3,4-Dichloro-phenyl)-2-imidazol-1-yl-cyclohexanol (1S,2S)-1-(3,4-Dichloro-phenyl)-2-[1,2,4]triazol-1-yl-cycloheptanol 3-(3-Chloro-phenyl)-2-cyano-3-(3,4-dichloro-phenyl)-propionic acid methyl ester

合成工艺路线路线简述

  • 18282-59-2 = 79175-35-2
    反应条件:1.1 Reagents: Magnesium Catalysts: 1,2-Dibromoethane Solvents: Diethyl Ether; 1 H,Rt
    标题:Asymmetric Addition Of Grignard Reagents To Ketones: Culmination Of The Ligand-Mediated Methodology Allows Modular Construction Of Chiral Tertiary Alcohols
    作者:Monasterolo,Claudio; O'Gara,Ryan; Kavanagh,Saranna E.; Byrne,Sadbh E.; Bieszczad,Bartosz; Et Al
    参考文献:Chemical Science 日期:2022 卷标:13(21) 页码:6262-6269]

    18282-59-2 = 79175-35-2
    反应条件:1.1 Reagents: Magnesium Solvents: Diethyl Ether,Tetrahydrofuran; Rt; Rt -> 50 °C
    标题:Enantioselective Synthesis Of Chiral Cyclic Hydrazines By Ni-Catalyzed Asymmetric Hydrogenation
    作者:Wang,Siwei; Xie,Chaochao; Zhu,Yu; Zi,Guofu; Zhang,Zhanbin; Et Al
    参考文献:Organic Letters 日期:2023 卷标:25(20) 页码:3644-3648]

    18282-59-2 = 79175-35-2
    反应条件:1.1 Reagents: Magnesium Catalysts: 1,2-Dibromoethane Solvents: Tetrahydrofuran; Rt -> Reflux; Reflux; 1 H,Rt
    标题:Electro-Olefination-A Catalyst Free Stereoconvergent Strategy For The Functionalization Of Alkenes
    作者:Baumann,Andreas N.; Music,Arif; Dechent,Jonas; Mueller,Nicolas; Jagau,Thomas C.; Et Al
    参考文献:Chemistry - A European Journal 日期:2020 卷标:26(38) 页码:8382-8387]

    18282-59-2 = 79175-35-2
    反应条件:1.1 Reagents: Magnesium Catalysts: Iodine Solvents: Diethyl Ether; 10 Min,Rt; 3 H,Rt
    标题:Ring-Opening/annulation Reaction Of Cyclopropyl Ethanols: Concise Access To Thiophene Aldehydes Via C-S Bond Formation
    作者:Wang,Ting; An,Zhenyu; Qi,Zhenjie; Zhuang,Daijiao; Chang,Aosheng; Et Al
    参考文献:Organic Chemistry Frontiers 日期:2019 卷标:6(21) 页码:3705-3709]

    18282-59-2 = 79175-35-2
    反应条件:1.1 Reagents: Magnesium Catalysts: 1,2-Dibromoethane Solvents: Tetrahydrofuran; 45 °C; 3 H,Reflux
    标题:Organotitanium Nucleophiles In Asymmetric Cross-Coupling Reaction: Stereoconvergent Synthesis Of Chiral α-Cf3 Thioethers
    作者:Varenikov,Andrii; Gandelman,Mark
    参考文献:Journal Of The American Chemical Society 日期:2019 卷标:141(28) 页码:10994-10999

海关参考信息

专利信息


专利号:US-10266481-B2
优先权日:2014-06-20
标题:Organocatalytic asymmetric synthesis of antidepressants
发明人：VAITHIYANATHAN VENKATARAMASUBRAMANIAN; KALSHETTI RUPALI GUNDAPPA; ARUMUGAM SUDALAI
权利人:COUNCIL SCIENT IND RES
摘要:The present invention relates to a short enantioselective synthesis of 1-amino aryl tetraline compounds of Formula 1 via nucleophilic enamine catalysis using organocatalyst such as proline. n n n n n n n n n n n n wherein R 1 and R 2 represent independent of each other hydrogen, (un)substituted or substituted amine; n R 3 and R 4 represent independent of each other hydrogen or halogen.

专利号:US-4710513-A
优先权日:1979-08-17
标 题:Substituted pyranone inhibitors of cholesterol synthesis
发明人：WILLARD ALVIN K; NOVELLO FREDERICK C; HOFFMAN WILLIAM F; CRAGOE JR EDWARD J
权利人:MERCK & CO INC
摘要:6-Phenyl-, phenylalkyl- and phenylethenyl-4-hydroxytetrahydropyran-2-ones in the 4(R)-trans stereoisomeric forms are potent inhibitors of cholesterol synthesis by virtue of their ability to inhibit the enzyme, 3-hydroxy-3-methylglutaryl-coenzyme A reductase.

专利号:US-4459422-A
优先权日:1979-08-17
标 题:Substituted pyranone inhibitors of cholesterol synthesis
发明人：WILLARD ALVIN K; NOVELLO FREDERICK C; HOFFMAN WILLIAM F; CRAGOE JR EDWARD J
权利人:MERCK & CO INC
摘要:6-Phenyl-, phenylalkyl- and phenylethenyl-4-hydroxytetrahydropyran-2-ones in the 4(R)-trans stereoisomeric forms are potent inhibitors of cholesterol synthesis by virtue of their ability to inhibit the enzyme, 3-hydroxy-3-methylglutaryl-coenzyme A reductase.

专利号:US-4375475-A
优先权日:1979-08-17
标 题 :Substituted pyranone inhibitors of cholesterol synthesis
发明人：WILLARD ALVIN K; NOVELLO FREDERICK C; HOFFMAN WILLIAM F; CRAGOE JR EDWARD J
权利人:MERCK & CO INC
摘要:6-Phenyl-, phenylalkyl- and phenylethenyl-4-hydroxytetrahydropyran-2-ones in the 4(R)-trans stereoisomeric forms are potent inhibitors of cholesterol synthesis by virtue of their ability to inhibit the enzyme, 3-hydroxy-3-methylglutaryl-coenzyme A reductase.

专利号:WO-2024159724-A1
优先权日:2023-02-03
标 题:O-biphenyl oxazoline compound and synthesis method therefor
发明人：ZHU JIANSHE; WANG MINGCHUN; LI QINGYI
权利人:KEYLAB JIANGSU TECH CO LTD
摘要:A synthesis method for an o-biphenyl oxazoline compound. An aryl metal compound as represent by formula II reacts with aryl oxazoline as represented by formula III to generate the o-biphenyl oxazoline compound as represented by formula I. The o-biphenyl oxazoline compound can be used for industrial preparation of o-aminobiphenyl compounds, and used for synthesizing succinate dehydrogenase inhibitor fungicides (IV) such as fluxapyroxad, bixafen, boscalid, and pyraziflumid.

专利号:US-4567289-A
优先权日:1979-08-17
标 题 :Substituted pyranone inhibitors of cholesterol synthesis
发明人：WILLARD ALVIN K; NOVELLO FREDERICK C; HOFFMAN WILLIAM F; CRAGOE JR EDWARD J
权利人:MERCK & CO INC
摘要:The methyl, ethyl, n-propy, 2-(acetylamino)ethyl, or 1-(2,3-dihydroxy)propyl ester of E-(3R,5S)-7-(4'-fluoro-3,3',5-trimethyl[1,1'-biphenyl]-2-yl)-3,5-dihyd roxy-6-heptenoic acid of structural formula: are HMG-CoA reductase inhibitors useful in the treatment of conditions associated with hypercholesterolemia.

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摘要:Okumura, M., Science of Synthesis: Dearomatizations, (2026) .
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