CAS: 78667-04-6; 2-(Chloromethyl)-1-Methyl-1H-Imidazole Hydrochloride
该化合物是一种多用途的七环化合物,具有活性氯甲基组和一聚二氮核心,其结构特性使它成为有机合成中的宝贵中间体,特别是用于制备药品,农用化学品和二聚二苯乙烯衍生物.盐能增强稳定性和溶解性,便利处理和储存.化合物的再活性允许有选择地修改,使核细胞替代反应和生物活性分子合成的应用成为可能.其明确界定的晶体形式可以确保始终保持纯度,适合需要精确化学构造的研究和工业规模过程.
- 英文名称2-(Chloromethyl)-1-Methyl-1H-Imidazole Hydrochloride
- 中文名称2-(氯甲基)-1-甲基-1H-咪唑(盐酸盐)
- IUPAC名称2-(chloromethyl)-1-methyl-1H-imidazole hydrochloride
- 其它别名Hydrochloride ; 2-(Chloromethyl)-1-Methyl-1H-Imidazole, Hcl ; 2-Chloromethyl-1-Methyl-1H-Imidazole Hydrochloride ; 2-(Chloromethyl)-1-Methyl-1H-Imida
- CAS编号78667-04-6
- MFCD编号:MFCD00234118
- EINECS号:640-792-0
- 分子式:C5H8Cl2N2分子量:167.04
- 产品CID: 1781310
- 产品分类有机原料→分子砌块→芳杂环类化合物→咪唑类化合物
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欧盟法规
ECHA物质C&L通报合成工艺路线路线简述
📜1-甲基-2-羟甲基-1H-咪唑置于氯化亚砜体系中,化学反应 0.25H,以85%的收率获得产物2-(氯甲基)-1-甲基-1H-咪唑盐酸盐
参考文献:可逆的丙烯酸化镍催化的分子间和分子内芳基硫醚的复分解反应.
标题:可逆的丙烯酸化镍催化的分子间和分子内芳基硫醚的复分解反应.
摘要:已经开发出镍催化的芳基硫醚复分解反应来获得高价值的硫醚.1,2-双(二环己基膦基)乙烷(dcype)对于促进这种高度官能团耐受的反应至关重要.此外,在不涉及烯键的闭环易位的不寻常实例中,可以高收率获得具有合成挑战性的大环化合物.深入的有机金属研究支持产物形成的可逆ni0 / Niii途径.总体而言,这项工作不仅为以前的基于pd的催化体系提供了更可持续的替代方法,而且还提出了与异常单键易位反应的进一步开发和应用高度相关的新应用和机理信息.
DOI:10.1002/anie.201910436
海关参考信息
- 2903110000-一氯甲烷及氯乙烷
- 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-12275733-B2
优先权日:2016-11-07
标 题:Substituted pyrido[3,4-b]indoles for the treatment of cartilage disorders
发明人：GRETZKE DIRK; RITZELER OLAF; HEINELT UWE; WEHNER VOLKMAR; SCHMIDT FRIEDEMANN
权利人:SANOFI SA
摘要:The present invention relates to 8-aryl-substituted and 8-heteroaryl-substituted 9H-pyrido[3,4-b]indoles of the formula (I), in which A, E, G, R1 to R6 and R10 are as defined in the claims, which stimulate chondrogenesis and cartilage matrix synthesis and can be used in the treatment of cartilage disorders and conditions in which a regeneration of damaged cartilage is desired, for example joint diseases such as osteoarthritis. The invention furthermore relates to processes for the synthesis of the compounds of the formula (I), their use as pharmaceuticals, and pharmaceutical compositions comprising them.
专利号:RU-2039050-C1
优先权日:1989-09-26
标 题:Derivatives of 1,2,4-triazole, optically inert or containing r- or s-configuration at c-2 and c-3 asymmetric centers, or their salts showing fungicide activity, and a method of their synthesis
专利号:RU-2194701-C2
优先权日:1995-12-18
标 题 :Derivatives of quinazoline, methods of their synthesis, pharmaceutical composition comprising thereof and method of achievement of anti-angiogenic effect and/or effect of decrease of vascular penetration with their using
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合成参考文献
参考文献:10.1007/978-90-481-2582-1_4
摘要:Cragg PJ. Supramolecular Enzyme Mimics. 2010. In: Supramolecular Chemistry.
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