CAS: 7755-92-2; 1-Piperazinecarbaldehyde

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57260-70-5 57260-71-6 245487-45-0

上下游产品

CAS号110-85-0 哌嗪 | CAS号107-31-3 甲酸甲酯 | CAS号201230-82-2 carbon monoxide | CAS号68-12-2 N,N-二甲基甲酰胺 | CAS号67-66-3 氯仿 | CAS号73486-77-8 piperazine-oxalate | CAS号4164-39-0 1.4-吡嗪二甲醛 | CAS号109-94-4 甲酸乙酯 | CAS号77287-34-4 甲亚胺酸 | CAS号1731-86-8 十一酸甲酯 | CAS号21863-67-2 1-Piperazinecar... | CAS号183383-30-4 4-甲酰基哌嗪-1-羧酸叔丁酯 | CAS号210553-81-4 1-Piperazinecar... | CAS号106-48-9 对氯苯酚 | CAS号1849-36-1 4-硝基苯硫酚 | CAS号57238-77-4 4-benzoyl-1-pip... | CAS号57238-78-5 1-(4-chloro-ben... | CAS号57238-80-9 1-(4-methyl-ben... | CAS号371-41-5 4-氟苯酚

哌嗪 反应生成 1-甲醛哌嗪
参考文献:Duranleau,R. G.;Knifton,J. F.;Speranza,G. P.
标题:Duranleau,R. G.;Knifton,J. F.;Speranza,G. P.

专利信息

专利号:WO-9740025-A1
优先权日:1996-04-19
标 题 :Solid phase and combinatorial synthesis of substituted 1,2,3-triazoles and of arrays of substituted 1,2,3-triazoles
发明人：DOERWALD FLORENCIO ZARAGOZA
权利人:NOVO NORDISK AS; DOERWALD FLORENCIO ZARAGOZA
摘要:A solid phase method for the synthesis of a plurality of differently substituted 1,2,3-triazoles with a wide variety of side-chain substituents as compounds of potential therapeutic interest. The 1,2,3-triazoles are prepared by acylation of a substrate-bound primary or secondary amine with a 3-oxoalkanoic acid and reaction of the resulting amide with a primary amine under dehydrating conditions to give an enamine. Treatment of this substrate-bound enamine with a sulfonyl azide in the presence of a base gives the corresponding 1,2,3-triazoles. These may be screened on the substrate or cleaved from the substrate and then screened in solution. The efficient synthesis of a wide variety of 1,2,3-triazoles using automated synthesis technology of the present method makes these compounds attractive candidates for the generation and rapid screening of diverse triazole-based libraries. The method disclosed here provides an easy and fast access to highly diverse heterocyclic compounds of therapeutic interest, amenable to automatization.

专利号:US-7429658-B2
优先权日:2003-09-11
标题 :Synthesis of protected pyrrolobenzodiazepines
发明人：HOWARD PHILIP; MASTERSON LUKE
权利人:SPIROGEN LTD
摘要:A method of synthesis of a N-10 protected PBD compound of formula (I): n nvia an intermediate of formula (II) or formula (V):

专利号:US-7557099-B2
优先权日:2004-03-01
标题 :Pyrrolobenzodiazepines as key intermediates in the synthesis of dimeric cytotoxic pyrrolobenzodiazepines
发明人：HOWARD PHILIP WILSON; KANG GYOUNG-DONG
权利人:SPIROGEN LTD
摘要:Compounds and a method of synthesis of compounds of formula (Ia) or (Ib): and salts, solvates, and chemically protected forms thereof, wherein the dotted lines indicate the optional presence of a double bond between C1 and C2 or C2 and C3; R 2 and R 3 are independently selected from —H, â•?O, â•?CH 2 , —CN, —R, OR, halo, â•?CH—R, O—SO 2 —R, CO 2 R and COR; R 10 is a carbamate-based nitrogen protecting group; and R 11 is an oxygen protecting group.

专利号:US-10155772-B2
优先权日:2010-07-08
标题:Process for the synthesis of substituted morphinans
发明人：DUNCAN SCOTT
权利人:ALKERMES PHARMA IRELAND LTD
摘要:The invention further relates to a process for the synthesis of 3-carboxamide substituted morphinans where a 3-cyano substituted 6-oxo substituted morphinan is reacted with a 1,3-diol.

专利号:US-9006425-B2
优先权日:2009-03-18
标题:Aluminum complexes and their use in the synthesis of cyclic carbonates
发明人：NORTH MICHAEL
权利人:NORTH MICHAEL; UNIV YORK
摘要:Dimeric aluminum catalysts of formula I: and their use in catalyzing the synthesis of cyclic carbonates from epoxides and carbon dioxide.

专利号:US-9029543-B2
优先权日:2011-04-05
标 题:Process for the synthesis of quaternary amine compounds
发明人：DUNCAN SCOTT
权利人:DUNCAN SCOTT; ALKERMES INC
摘要:The invention relates to a process for the synthesis of quaternized compounds of formula: