CAS: 694-31-5; 1,5-Dimethyl-1H-Pyrazole

相似化合物

1072-91-9 66121-72-0 694-48-4

上下游产品

CAS号5436-21-5 4,4-二甲氧基-2-丁酮 | CAS号60-34-4 甲基肼 | CAS号78-94-4 丁烯酮 | CAS号1402242-75-4 potassium (1,3-... | CAS号1402242-76-5 potassium (1,5-... | CAS号1453-58-3 3-甲基吡唑 | CAS号77-78-1 硫酸二甲酯 | CAS号5744-51-4 1,5-二甲基-1H-吡唑-3-甲酸乙酯 | CAS号85290-77-3 1,5-二甲基-1H-吡唑-4-羧酸乙酯 | CAS号34605-61-3 ethyl 3-amino-1... | CAS号92534-69-5 1-甲基-4-硝基-1H-吡唑-5-羧酸 | CAS号92534-73-1 4-氨基-1-甲基-1H-吡唑... | CAS号132417-20-0 5-Dibenzoylmeth... | CAS号93-97-0 苯甲酸酐 | CAS号84547-84-2 4-溴-2-甲基-2H-吡唑-3-羧酸 | CAS号84547-83-1 4-氯-1-甲基-1H-吡唑-5-羧酸 | CAS号694-48-4 1,3-二甲基吡唑 | CAS号5775-86-0 4-溴-1,5-二甲基-1H-吡唑 | CAS号6338-45-0 1,4-二甲基-1H-咪唑 | CAS号10447-93-5 1,5-二甲基-1H-咪唑

1,5-二甲基-1H-吡唑-4-羧酸乙酯置于sodium Hydroxide体系中,用 乙醇 作为反应溶剂,化学反应 1.0H,反应生成 1,5-二甲基-1H-吡唑
参考文献:Systemic Fungicides. The Synthesis Of Certain Pyrazole Analogues Of Carboxin
标题:Systemic Fungicides. The Synthesis Of Certain Pyrazole Analogues Of Carboxin
摘要:介绍了 1,3-二甲基-N-苯基吡唑-4-甲酰胺(3)和异构体 1,5-二甲基化合物(4)的合成方法. 1,3-二甲基-N-苯基吡唑-4-甲酰胺(3)和异构体 1,5-二甲基化合物(4)的合成方法. 羧菌素的结构类似物.本文提出了证实这些化合物结构归属的证据,并介绍了一种简便的 并介绍了从一些氨基吡唑中去除氨基的简便方法. 基的简便方法.
DOI:10.1071/ch9830135

专利信息

专利号:US-2018051042-A1
优先权日:2016-08-22
标题 :Methods for forming saturated (hetero)cyclic borylated hydrocarbons and related compounds
发明人：SMITH III MILTON R; SHANNON TIMOTHY M; MALECZKA JR ROBERT E; FORNWALD RYAN M
权利人:UNIV MICHIGAN STATE
摘要:The disclosure relates to methods for forming at least partially saturated cyclic and heterocyclic borylated hydrocarbons, as well as related compounds, which can be precursor compounds in the synthesis of any of a variety of pharmaceutical or medicinal compounds with a desired structure and/or stereochemistry for drug synthesis or drug candidate evaluation. The methods generally include reduction of an unsaturated cyclic or heterocyclic borylated hydrocarbon having a boron-containing substituent at an sp 2 -carbon, where such reduction converts the sp 2 -carbon to an sp 3 -carbon at the point of attachment of the boron-containing substituent. The methods can exhibit a selectivity for syn-addition during reduction, which can provide stereospecific products, such as when the unsaturated cyclic or heterocyclic reactant is multiply substituted with boron groups and/or other functional groups.

专利号:US-7129361-B2
优先权日:1998-04-15
标 题 :Thienylazolylalkoxyethanamines, their preparation and their application as medicaments
发明人：MERCE-VIDAL RAMON; ANDALUZ-MATARO BLAS; FRIGOLA-CONSTANSA JORDI
权利人:ESTEVE LABOR DR
摘要:The thienylazolylalkoxyethanamines (I) where R1 is a hydrogen atom, a halogen atom or a lower alkyl radical; R2, R3 and R4 represent, independently, a hydrogen atom or a lower alkyl radical; and Az represents a five-member nitrogenated hetercyclic aromatic group, N-methyl-substituted, that contains from one to three nitrogen atoms. They have analgesic activity in mammals, including humans. The compounds (I) can be obtained, for example, by reaction of a derivative of hydroxy-thienylazol (IV) with a derivative of a suitable N-(ethyl)amine. The compounds (IV) are useful intermediates in the synthesis of the compounds (I). The compounds (I) have an application in human and/or veterinary medicine.

专利号:US-6103865-A
优先权日:1998-08-03
标 题 :PH-sensitive polymer containing sulfonamide and its synthesis method
发明人：BAE YOU HAN; PARK SANG YEOB
权利人:KWANGJU INST SCI & TECH
摘要:There are disclosed pH-sensitive polymers containing sulfonamide groups, which can be changed in physical properties, such as swellability and solubility, depending on pH and which can be applied for a drug-delivery system, bio-material, sensor, etc, and a preparation method therefor. The pH-sensitive polymers are prepared by introduction of sulfonamide groups, various in pKa, to hydrophilic groups of polymers either through coupling to the hydrophilic groups, such as acrylamide, N,N-dimethylacrylamide, acrylic acid, N-isopropylacrylamide, etc, of polymers or copolymerization with other polymerizable monomers. These pH-sensitive polymers may have a structure of linear polymer, grafted copolymer, hydrogel or interpenetrating network polymer.

专利号:US-10000487-B2
优先权日:2015-11-20
标 题 :Heterocyclic compounds that inhibit the kinase activity of Mnk useful for treating various cancers
发明人：SPRENGELER PAUL A; REICH SEIGFRIED H; WEBBER STEPHEN E; ERNST JUSTIN T
权利人:EFFECTOR THERAPEUTICS INC
摘要:The present invention provides synthesis, pharmaceutically acceptable formulations and uses of compounds in accordance with Formula IA or Formula IB, as well as stereoisomers, tautomers or pharmaceutically acceptable salts thereof. n nFor Formula IA and Formula IB compounds A 1 , A 2 , A 3 , A 4 , W 1 , W 2 , Y, X, R 1 , R 2 , R 3 , R 4a , R 4b , R 5a , R 5b , R 6 , R 7 , R 8 , R 9 , R 9a , R 9b , R 10 and subscript n are as defined in the specification. The inventive Formula IA and Formula IB compounds are inhibitors of Mnk and find utility in any number of therapeutic applications, including but not limited to treatment of inflammation and various cancers.

专利号:WO-2023091726-A1
优先权日:2021-11-18
标题:Inhibitors of cyclin‑dependent kinase 12 (cdk12)
发明人：BENOIT GUILLAUME; CARULLI JOHN; CHEN FEI; CHUAQUI CLAUDIO; CIBLAT STEPHANE; COOPER ELLIOT; DAGENAIS ROBIN; HU SHANHU; KABRO ANZHELIKA; LAPLACA DEREK; MARINEAU JASON; MOEBIUS DAVID; MOON DIANE; SOLODININ ANDREI; WHITMORE KENNETH
权利人:SYROS PHARMACEUTICALS INC
摘要:The present invention provides chemical compounds that inhibit one or more families of kinases (e.g., serine/threonine kinases, including one or more of the families of CDK proteins, and in particular, CDK12). More specifically, the present invention provides CDK12 inhibitors, of formula (I), pharmaceutically acceptable salts and isotopically labeled derivatives thereof, pharmaceutical compositions containing the compounds/inhibitors, and methods of their synthesis and use in treating proliferative diseases (e.g., a bladder cancer, a breast cancer, Ewing's sarcoma, a gastric cancer, a gastrointestinal cancer, a hematologic cancer, a lung cancer (e.g., small cell lung cancer (SCLC)), an ovarian cancer (e.g., a high grade serous ovarian cancer), a pancreatic cancer (e.g., pancreatic ductal adenocarcinoma (PDAC)), a brain cancer (e.g., glioblastoma), or a prostate cancer), alone or in combination with a second therapeutic agent. The proliferative disease can be a cancer, benign neoplasm, or pathologic angiogenesis, and any of the therapeutic methods or uses described herein can include a step of diagnosing the patient's disease. In other embodiments of the invention, the compositions described herein (e.g., the compounds, pharmaceutical compositions, and kits containing them) are used for the treatment of myotonic dystrophy (type 1 or type 2).

专利号:CN-106916109-A
优先权日:2017-01-19
标 题 :A kind of protonated pyrazole ionic liquid and the method of using it to catalyze the synthesis of cyclic carbonate