CAS: 672323-32-9; Pyrazolo[1,5-A]Pyrimidine-5,7(4H,6H)-Dione
该化合物是一种环状化合物,其特点是一个包括和酸碱的引信环状系统,具有一个外环化合物的特征.该化合物通常展示一系列生物活动,使其对医药化学和药物开发感兴趣.其结构具有二元功能组,有助于其反应和与生物目标的潜在互动.环状系统中氮原子的存在可影响其溶性和稳定性,以及形成氢结的能力,而氢结对生物活动至关重要.对[1,5-a] 衍生物具有反食性,抗癌和抗病毒剂的潜力,经常受到调查.该化合物的具体特性,如熔点,溶性,光谱特性等,可根据其合成和纯度而有所不同.
- 英文名称Pyrazolo[1,5-A]Pyrimidine-5,7(4H,6H)-Dione
- 中文名称吡唑并[1,5-a]嘧啶-5,7(4H,6H)-二酮
- IUPAC名称pyrazolo[1,5-a]pyrimidine-5,7(4H,6H)-dione
- 其它别名嘧啶并吡唑-5,7(4H,6H)-二酮; 4H-Pyrazolo[1,5-A]Pyrimidine-5,7-Dione
- CAS编号672323-32-9
- MFCD编号:MFCD09953598
- 分子式:C6H5N3O2分子量:151.13
- 产品CID: 1654686
- 产品分类有机原料→分子砌块→芳杂环类化合物→吡唑类化合物
相似化合物
939979-42-7 1566311-96-3 1565855-43-7MSDS等安全信息
合成工艺路线路线简述
📜3-氨基吡唑,丙二酸二甲酯置于sodium Methylate体系中,用 甲醇 作为反应溶剂,化学反应 18.0H,反应生成 吡唑并[1,5-A]嘧啶-5,7(4H,6H)-二酮
参考文献:Alicyclic Heterocyclic Compound
标题:Alicyclic Heterocyclic Compound
摘要:以下是该公式表示的脂环杂环化合物或其药用可接受盐: 其中环a是杂环,环b是碳环,杂环等,P1和p2是ch或n,Q和r为0至2,X为-Nh-,-O-,-Ch2-等,Y为-Ch2-,-Co-,-So2-等,Z为-Co-,-So2-等,R3为碳环基团,杂环基团,羟基,烷氧基或氨基,可用作ccr4功能的控制剂,用于预防或治疗支气管哮喘,特应性皮炎等.
海关参考信息
- 2912110000-甲醛
2912120000-乙醛
2924199090-其他无环酰胺
2921199090-其他无环单胺 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-8076479-B2
优先权日:2006-08-28
标题 :Process and intermediates for the synthesis of (3-alkyl-5-piperidin-1-yl-3,3a-dihydro-pyrazolo[1,5-a]pyrimidin-7-yl)-amino derivatives and intermediates
发明人：CHEN FRANK XING; KEERTIKAR KARTIK M; KUO SHEN-CHUN; LEE HONG-CHANG; RAGHAVAN RAMANI R; WU GEORGE G; XIE JI
权利人:CHEN FRANK XING; KEERTIKAR KARTIK M; KUO SHEN-CHUN; LEE HONG-CHANG; RAGHAVAN RAMANI R; WU GEORGE G; XIE JI; SCHERING CORP
摘要:Disclosed is a process for the synthesis of compounds of Formula I n nby sequentially aminating, first with a primary amine and then with a secondary amine, an intermediate compound of the structure of Formula E1,n n nwherein R 1 is a linear, branched, or cyclic alkyloxy functional group of the structure (—R 2a —OH), R 2a is a linear, branched or cyclic alkyl group, R 2 is a linear, branched or cyclic alkyl group, and R 3 is an alkylene-heterocycle, said process comprising forming intermediate compound of Formula E1 by reacting, in a refluxing reaction solvent selected from alcohols having 5 or less carbon atoms and mixtures of two or more thereof, a methanol solution of a salt of a 4-alkyl-3-amino-pyrazole compound of Formula C1,n n nwith a diamidization reagent selected from dimethylmalonate, monomethylmalonyl-chloride, and malonyl dichloride in the presence of a Lewis base having sufficient proton affinity to abstract a proton from the 1-position nitrogen on the pyrazole ring.
专利号:US-2008058518-A1
优先权日:2006-08-28
标 题 :Process and intermediates for the synthesis of (3-alkyl-5-piperidin-1-yl-3,3a-dihydro-pyrazolo[1,5-a]pyrimidin-7-yl)-amino derivatives and intermediates
专利号:EP-2057166-B1
优先权日:2006-08-28
标题 :Process and intermediates for the synthesis of (3-alkyl-5-piperidin-1-yl-3,3a-dihydropyrazolo[1,5-a]pyrimidin-7-yl)-amino derivatives
专利号:EP-2057166-A2
优先权日:2006-08-28
标题 :Process and intermediates for the synthesis of (3-alkyl-5-piperidin-1-yl-3,3a-dihydro- pyrazoloý1,5-a¨pyrimidin-7-yl)-amino derivatives and intermediates
专利号:CA-2661737-C
优先权日:2006-08-28
标 题 :Process and intermediates for the synthesis of (3-alkyl-5-piperidin-1-yl-3,3a-dihydro-pyrazolo[1,5-a]pyrimidin-7-yl)-amino derivatives and intermediates
专利号:CN-101627041-A
优先权日:2006-08-28
标 题:Methods and intermediates for the synthesis of (3-alkyl-5-piperidin-1-yl-3,3A-dihydro-pyrazolo[1,5-A]pyrimidin-7-yl)-amino derivatives and intermediates body
