CAS: 6554-98-9; (E)-4-Styrylphenol

上下游产品

ethylmagnesium iodide E-1-(phenyl)-2-(4'-methoxyphenyl)ethene benzyltriphenylphosphonium chloride 4-hydroxy-benzaldehydetrans-stilbenyl-(4)-oxy)-ethyl]-aminediethyl-[2-(trans-stilbenyl-(4)-oxy)-ethyl]-amine trans-stilben-4-yloxy-acetonitriletrans-stilben-4-yloxy-acetonitrile trans-stilben-4-yloxy-propyl)-aminedibutyl-(3-trans-stilben-4-yloxy-propyl)-amine (Z)-1-(4-hydroxyphenyl)-2-phenylethene

📜4-碘乙酰基苯酚置于palladium Diacetate,三苯基膦,Lithium Hydroxide体系中,用 四氢呋喃,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 22.0H,反应生成 反式-4-羟基芪
参考文献:Galloyl Esters Of Trans-Stilbenes Are Inhibitors Of Fasn With Anticancer Activity On Non-Small Cell Lung Cancer Cells
标题:Galloyl Esters Of Trans-Stilbenes Are Inhibitors Of Fasn With Anticancer Activity On Non-Small Cell Lung Cancer Cells
摘要:Fatty Acid Synthase (Fasn) Is A Lipogenic Enzyme That Is Selectively Upregulated In Malignant Cells. There Is Growing Consensus On The Oncogenicity Of Fasn-Driven Lipogenesis And The Potential Of Fasn As A Druggable Target In Cancer. Here,We Report The Synthesis And Fasn Inhibitory Activities Of Two Novel Galloyl Esters Of Trans-Stilbene Ec1 And Ec5. Inhibition Of Fasn Was Accompanied By A Loss In Akt Activation And Profound Apoptosis In Several Non-Small Cell Lung Cancer (Nsclc) Cells At The Growth Inhibitory Concentrations Of Ec1 And Ec5. Both Fasn And Phospho-Akt Levels Were Concurrently Downregulated. However,Addition Of A Lipid Concentrate To The Treated Cells Reinstated Cell Viability And Reversed The Loss Of Fasn And Akt Protein Levels,Thus Recapitulating The Causal Relationship Between Fasn Inhibition And The Loss In Cell Viability. (C) 2019 Elsevier Masson Sas. All Rights Reserved.
DOI:10.1016/j.Ejmech.2019.111597