CAS: 6485-79-6; Triisopropylsilane

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89343-06-6 29681-57-0 18159-55-2

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CAS号10025-78-2 三氯氢硅 | CAS号1888-75-1 异丙基锂 | CAS号7440-21-3 硅 | CAS号75-29-6 2-氯丙烷 | CAS号67-56-1 甲醇 | CAS号1068-55-9 异丙基氯化镁 | CAS号124-41-4 甲醇钠 | CAS号109-88-6 甲醇镁 | CAS号67-63-0 异丙醇 | CAS号71-36-3 正丁醇 | CAS号105633-68-9 phenoxy-tri(pro... | CAS号98-86-2 苯乙酮 | CAS号60-29-7 乙醚 | CAS号76-05-1 三氟乙酸(TFA) | CAS号80522-42-5 三异丙基硅基三氟甲磺酸酯 | CAS号156275-96-6 三异丙基硅烷硫醇 | CAS号35856-38-3 tri(propan-2-yl... | CAS号33974-42-4 TRIISOPROPYLMET... | CAS号13154-24-0 三异丙基氯硅烷 | CAS号17903-14-9 phenyl-tri(prop...

2-氯丙烷置于三氯硅烷,Magnesium体系中,用80%的收率获得产物三异丙基硅烷
参考文献:The Triisopropylsilyl Group As A Hydroxyl-Protecting Function
标题:The Triisopropylsilyl Group As A Hydroxyl-Protecting Function
摘要:
DOI:10.1021/jo01311A058

专利信息

专利号:US-9920084-B2
优先权日:2011-08-23
标题 :Ionic tags for synthesis of oligoribonucleotides
发明人：DAMHA MASAD J; HASSLER MATTHEW; CHAN TAK-HANG; NANDYALA MALLIKARJUNA REDDY; DONGA ROBERT ALEXANDER
权利人:DAMHA MASAD J; HASSLER MATTHEW; CHAN TAK HANG; NANDYALA MALLIKARJUNA REDDY; DONGA ROBERT ALEXANDER; THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIV; HONG KONG POLYTECHNIC UNIV
摘要:The invention relates to the chemical synthesis of oligonucleotides, e.g., oligoribonucleotides. In another aspect, the invention relates to compounds of formula (II) processes for making these compounds, and the use thereof in the chemical synthesis of oligonucleotides, e.g., oligoribonucleotides. The invention also relates to methods of synthesis of oligomers, including but not limited to oligopeptides, oligosaccharides and oligonucleotides, particularly oligoribonucleotides and also oligodeoxyribonucleotides, in solution systems, and ionic tag linkers for use in methods provided herein.

专利号:US-2020010502-A1
优先权日:2018-07-05
标题 :Synthesis of multiphosphorylated peptides
发明人：FRIEDLER ASSAF; MAMDI SAMARA SIMHA REDDY; HUREVICH MATTAN
权利人:YISSUM RES DEV CO OF HEBREW UNIV JERUSALEM LTD
摘要:The present invention relates to a new approach for the synthesis of multiphosphorylated peptides. Specifically, the present invention provides a process, which enables the synthesis of multiphosphorylated peptides with up to seven phosphorylated Serine (pSer) and Threonine (pThr) residues, including such residues that are close in sequence.

专利号:US-7939679-B2
优先权日:2006-01-19
标题:Method for synthesis of ciguatoxin CTX1B and compounds useful for the synthesis of ciguatoxin CTX1B
发明人：HIRAMA MASAHIRO; INOUE MASAYUKI
权利人:JAPAN SCIENCE & TECH AGENCY
摘要:Disclosed is a method for total synthesis of CTX1B, which is developed for the synthesis of a ciguatoxin analogue such as CTX3C and enables the more efficient application of an established reaction to the total synthesis of CTC1B. More specifically, disclosed is a method for total synthesis of CTX1B comprising; an O.S-acetal formation for synthesizing a novel compound (3); a radical cyclization reaction for constructing a 9-membered ring formation reaction including a novel compound (6) through a novel compound (8) and yielding a compound (D); and a deprotection for yielding CTX1B. Also disclosed are novel compounds (1) to (8) which are particularly useful for synthesis of CTX1B and can be used for the synthesis of a ciguatoxin analogue.

专利号:US-2019292219-A1
优先权日:2018-03-26
标 题:Method of solid-state peptide synthesis using a novel polymeric support
发明人：JERABEK KAREL; HANKOVA LIBUSE; HOLUB LADISLAV; ZECCA MARCO; CENTOMO PAOLO; TROVO DANIELE; LEDER RICCARDO; BIONDI BARBARA
权利人:INST OF CHEMICAL PROCESS FUNDAMENTALS OF THE CAS V V I; UNIV DEGLI STUDI PADOVA
摘要:A method of solid-state synthesis of peptides that provides a polymeric solid-state synthesis support, attaches a first amino acid to said support to form the first amino acid molecule of the desired peptide chain, attaches additional amino acids to form the desired peptide chain, characterized in that the polymeric solid-state synthesis support is a styrenic polymer containing at least 50 mol % divinylbenzene monomer units, the styrenic polymer being functionalized with chloromethyl and/or benzyloxybenzyl alcohol and/or amino moieties, and having porosity 60-90% and medium pore diameter ranging from 10 to 80 nm. A functionalized styrenic polymer is claimed.

专利号:US-11548898-B2
优先权日:2017-07-06
标题 :Synthesis of halichondrins
发明人：KISHI YOSHITO; AI YANRAN; YE NING; WANG QIAOYI; YAHATA KENZO; ISO Kentaro; NAINI SANTHOSH REDDY; YAMASHITA SHUJI; LEE JIHOON; OHASHI ISAO; FUKUYAMA TAKASHI
权利人:HARVARD COLLEGE; EISAI R&D MAN CO LTD
摘要:The present invention provides methods for the synthesis of ketones involving a Ni/Zr-mediated coupling reaction. The Ni/Zr-mediated ketolization reactions can be used in the synthesis of halichondrins (e.g., halichondrin A, B, C; homohalichondrin A, B, C; norhalichondrin A, B, C), and analogs thereof. Therefore, the present invention also provides synthetic methods useful for the synthesis of halichondrins, and analogs thereof. Also provided herein are compounds (i.e., intermediates) useful in the synthesis of halichondrins, and analogs thereof. In particular, the present invention provides methods and compounds useful in the synthesis of compound of Formula (H3-A).

专利号:US-2008032964-A1
优先权日:2006-04-10
标题:Process for the synthesis of azetidinone
发明人：KANSAL VINOD K; AHMAD SUHAIL; MARIAPPAN SHANMUGAVEL; TYAGI BHUPENDRA; PERLMAN NURIT; LE PAIH JACQUES; ZANOTTI-GEROSA ANTONIO
权利人:KANSAL VINOD K; AHMAD SUHAIL; MARIAPPAN SHANMUGAVEL; TYAGI BHUPENDRA; PERLMAN NURIT; LE PAIH JACQUES; ZANOTTI-GEROSA ANTONIO
摘要:Provided are intermediates useful for the synthesis of hydroxyl-alkyl substituted azetidinones, processes of their preparation, and processes for the synthesis of certain hydroxyl-alkyl substituted azetidinones. Also provided are processes for the synthesis of 1-(4-fluorophenyl)-3(R)-[3-(4-fluorophenyl)-3(S)-hydroxypropyl]-4(S)-(4-hydroxyphenyl)-2-azetidinone, or ezetimibe.