CAS: 64263-80-5; (2S,3R)-3-(Benzyloxy)-2-((Tert-Butoxycarbonyl)(Methyl)Amino)Butanoic Acid

相似化合物

131545-63-6 198561-81-8 69863-36-1

上下游产品

N-B°C-O-benzyl-L-threonine methyl iodideB°C-MeThr(OBzl)-Abu-Sar-MeLeu-Val-MeLeu-Ala-OBzl (2S,3R)-N-B°C-N-methyl-O-benzyl-L-threonine trimethylsilyl ester butanoate2,2,2-trichloroethyl(2S,3R)-3-benzyloxy-2-butanoate 2,2,2-trichloroethyl(2S,3R)-3-benzyloxy-2-(N)-methylaminobutanoate

📜N-Boc-O-苄基-L-苏氨酸,碘甲烷置于sodium Hydride体系中,用 四氢呋喃 作为反应溶剂,以73%的收率获得产物n-叔丁氧羰基-N-甲基-O-苄基-L-苏氨酸
参考文献:Synthesis Towards Microcystins And Related Toxins
标题:Synthesis Towards Microcystins And Related Toxins
摘要:文中描述了一般制备微囊藻毒素和节球藻毒素的路线,包括制备β-甲基-D-天冬氨酸的新化学方法.
DOI:10.1039/cc9960001683

专利信息

专利号:US-5633346-A
优先权日:1992-06-19
标 题:Process for systhesizing cyclic peptides
发明人：KUROME TORU; TAKESAKO KAZUTOH; KATO IKUNOSHIN; INAMI KAORU; SHIBA TETSUO
权利人:TAKARA SHUZO CO
摘要:A process is provided for the total synthesis of a cyclic peptide, which is useful as antifungal drug, and novel compounds prepared by the synthesis method. The cyclic peptide is represented by the following formula (I): (I) wherein X1, X2, X4 and X7 are independently N-methyl- alpha -amino acid or alpha -hydroxy acid, provided that at least one of X1, X2, X4 and X7 is an alpha -hydroxy acid; X3, X6 and X8 are independently alpha -amino acid; X5 is a cyclic amino acid; X9 is an N-methyl- alpha -amino acid or alpha -hydroxy acid substituted by a hydroxy group; and the dotted lines represent intramolecular hydrogen bonds. The process includes cyclizing a corresponding linear peptide between X5 and X6 via a peptide bond.