CAS: 634-19-5; 1,2,3,4-Tetrahydro-9H-Fluoren-9-One

📜2-二氮杂-1-苯乙酮置于正丁基锂,三(五氟苯基)硼烷,二异丙胺体系中,用 四氢呋喃,正己烷,二氯甲烷 作为反应溶剂,化学反应 0.17H,反应生成 1,2,3,4-四氢-9-芴酮
参考文献:乙烯基阳离子对芳环的分子内乙烯基化.
标题:乙烯基阳离子对芳环的分子内乙烯基化.
摘要:据报道,路易斯酸通过乙烯基阳离子介导芳基环的分子内亲电性乙烯基化.该反应利用β-羟基-α-重氮酮作为乙烯基阳离子前体,并提供了具有七元环的三环1-茚满的非常好产率.延伸将乙烯基阳离子束缚到芳族环的烷烃链会反应生成2-萘酚和2-茚满酮产物.
DOI:10.1021/acs.Orglett.8B03054

专利信息

专利号:US-2025313590-A1
优先权日:2024-03-16
标题:Phosphoramidite morpholino monomers towards synthesis/convergent synthesis of PMO, TMO, their chimera oligos in 5 prime to 3 prime direction
发明人：SINHA SURAJIT; GHOSH ATANU; BANERJEE ARPAN
权利人:INDIAN ASS FOR THE CULTIVATION OF SCIENCE
摘要:The present invention relates to 5′-morpholino amidite monomers as 5′-CE/5′- t Bu phosphoramidite morpholino monomers (2) and process chemistry for the efficient synthesis of N-Trityl or monomethoxytrityl (MMTr)-protected 5′-morpholino amidite monomers and their use in the synthesis of phosphorodiamidate morpholino oligonucleotides (PMO), thiophosphoramidate morpholino oligonucleotides (TMO) and their chimeras which can be used for antisense technology or in general oligonucleotides related research.

专利号:US-12012427-B2
优先权日:2019-10-31
标 题 :Synthesis of Fmoc-protected morpholino monomers and their use in the synthesis of morpholino oligomer
发明人：SINHA SURAJIT; KUNDU JAYANTA; GHOSH UJJWAL
权利人:INDIAN ASS FOR THE CULTIVATION OF SCIENCE
摘要:Present invention relates to stable Fmoc protected Morpholino monomers and corresponding oligonucleotides (PMO) and efficient synthesis of the same involving chlorophosphoramidate and H-Phosphonate chemistry. Successful syntheses of the oligonucleotide with higher yield and lesser time have been accomplished employing solid phase synthesis and easy deprotection of Fmoc group with Piperidine.

专利号:US-11427596-B2
优先权日:2019-07-19
标 题:Metal-free solvent-free synthesis of fused-pyrido heterocycles and biomedical applications
发明人：CHELVAM VENKATESH; DUDHE PREMANSH; KRISHNAN MENA ASHA; SONAWANE AVINASH
权利人:INDIAN INSTITUTE OF TECH INDORE
摘要:Embodiments herein provide fused-pyrido heterocycles such as azaindoles, carboline derivatives, furo[b]pyridines or furo[b]pyridine-isatin hybrids of Formula I.Embodiments also relate to a process for a synthesis of variety of complex pyrido-heterocycles The pyrido-heterocycles can be used for treating cancer (cervix, kidney, lung, breast and epidermal skin) and multi-drug resistant tuberculosis. These heterocycles can also be used as anti-biofilm agents against pathogenic strains, which will minimize the risk of secondary infections.

专利号:US-11548898-B2
优先权日:2017-07-06
标题 :Synthesis of halichondrins
发明人：KISHI YOSHITO; AI YANRAN; YE NING; WANG QIAOYI; YAHATA KENZO; ISO Kentaro; NAINI SANTHOSH REDDY; YAMASHITA SHUJI; LEE JIHOON; OHASHI ISAO; FUKUYAMA TAKASHI
权利人:HARVARD COLLEGE; EISAI R&D MAN CO LTD
摘要:The present invention provides methods for the synthesis of ketones involving a Ni/Zr-mediated coupling reaction. The Ni/Zr-mediated ketolization reactions can be used in the synthesis of halichondrins (e.g., halichondrin A, B, C; homohalichondrin A, B, C; norhalichondrin A, B, C), and analogs thereof. Therefore, the present invention also provides synthetic methods useful for the synthesis of halichondrins, and analogs thereof. Also provided herein are compounds (i.e., intermediates) useful in the synthesis of halichondrins, and analogs thereof. In particular, the present invention provides methods and compounds useful in the synthesis of compound of Formula (H3-A).

专利号:WO-2023030277-A1
优先权日:2021-08-30
标 题:Method for fully liquid-phase synthesis of grnh nonapeptide amide analog
发明人：SUN PENGCHENG; PAN JING; WU JUNYONG; TANG YONGBO; Du Yixiong; GUO LIN
权利人:HUNAN MICRO PEPTIDE BIOMEDICAL CO LTD
摘要:Provided is a method for fully liquid-phase synthesis of a GRnH nonapeptide amide analog, which belongs to the technical field of medicine synthesis. The method comprises respectively synthesizing a 'Trp-Ser-Tyr' fragment, an 'R-Leu' fragment, a 'Pyr-His' fragment and 'Arg-Pro-Hunan T', wherein, R = D-Ala (alarelin), D-Leu (leuprorelin), D-Trp (deslorelin) and D-His (histrelin), and obtaining the GRnH nonapeptide amide analog with high yield and high purity by means of a '3 +2 +2 +2' fragment condensation method. The synthesis method is environmentally friendly, mild, and free of any highly toxic and poisonable reagents. The cost is greatly reduced and the synthesis method is very suitable for large-scale production.

专利号:WO-2025163681-A1
优先权日:2024-02-01
标 题:Thf coordinated monomeric group 13 metal alkoxide adducts, synthesis and catalytic activity thereof
发明人：CHAKRABORTY DEBASHIS; ROY SOURAV SINGHA; SARKAR SRIPARNA
权利人:INDIAN INSTITUTE OF TECH MADRAS
摘要:The present invention discloses monomeric THF coordinated Group 13 metal alkoxides, synthesis and catalytic activity thereof The method of synthesis of monomeric THF coordinated Group 13 metal alkoxides (formula I) described in the present invention yields alkyl alcohol adducts of Group 13 metal (Aluminum, Gallium, and Indium) alkoxides have their fourth coordination satisfied. The catalytic activity of the Group 13 metal alkoxide adduct compounds is useful for the ring opening polymerization (ROP) of compounds such as racemic lactide to yield PLA. These Group 13 metal alkoxide adducts initiate polymerization under milder reaction conditions as compared to tin octanoate and thus can serve as catalyst for synthesis of polymers like PLA,Polycaprolactone with 10 high molecular weight.