CAS: 6328-58-1; 6-Methyl-2-(Methylthio)-1H-Pyrimidin-4-One

相似化合物

5751-20-2 3019-18-9 934365-38-5

上下游产品

4-(N-benzylcarbamoylethoxy)-6-methyl-2-methylthiopyrimidine H-pyrimidin-4-one6-methyl-2-methylsulfanyl-5-piperidinomethyl-3H-pyrimidin-4-one 5-chloro-6-methyl-2-(methylthio)pyrimidin-4(3H)-one 3-butyl-6-methyluracil 4-nitro-benzenesulfonic acid-(4-methyl-6-oxo-1,6-dihydro-pyrimidin-2-ylamide)

📜甲基硫脲嘧啶,碘甲烷置于sodium Hydroxide体系中,用 乙醇 作为反应溶剂,化学反应 0.03H,反应生成 6-甲基-4-羟基-2-甲硫基嘧啶
参考文献:微波辐射下2-溴甲基-3-羟基-2-羟基甲基丙基嘧啶和茶碱核苷的合成.评估其抗乙型肝炎病毒活性
标题:微波辐射下2-溴甲基-3-羟基-2-羟基甲基丙基嘧啶和茶碱核苷的合成.评估其抗乙型肝炎病毒活性
摘要:用2,2-双(溴甲基)-1,3-二乙酰氧基丙烷将2-甲硫基嘧啶-4(1H)-一(1A)及其5(6)-烷基衍生物1B-D和茶碱(7)烷基化(2)在微波辐射下得到相应的无环核苷1-[((3-乙酰氧基-2-乙酰氧基甲基-2-溴甲基)丙-1-基]-2-甲基-硫代嘧啶-4(1H)-酮3A-d和7-[(3-乙酰氧基-2-乙酰氧基甲基-2-溴甲基)丙-1-基]茶碱(8),在进一步辐射下,得到双头无环核苷1,1'-[(2,2-二乙酰氧基甲基))-1,3-亚丙基]-双[(2-(甲硫基)-嘧啶-4(1H)-Ones] 4A-c和7,7'-[(2,2-二乙酰氧基甲基)-1,3-(9).通过甲醇钠的作用获得了脱乙酰基衍生物,并评估了脱乙酰基核苷对乙型肝炎病毒的活性. 化合物5B显示出对hbv的中等抑制活性,具有轻度的细胞毒性.
DOI:10.1080/15257770600793919

专利信息

专利号:US-11028057-B2
优先权日:2018-02-28
标题:Process for the synthesis of 6-chloromethyluracil
发明人：MORANA FABIO; GOBBATO STEFANO; ROLETTO JACOPO; PAISSONI PAOLO
权利人:PROCOS SPA
摘要:The invention relates to a process for the synthesis of 6-chloromethyluracil (6-(chloromethyl)pyrimidin-2,4(1H,3H)-dione) from ethyl 4-chloroacetoacetate and S-methylisothiourea hemisulfate via isolation of the novel intermediate 6-(chloromethyl)-6-hydroxy-2-(methylthio)-5,6-dihydropyrimidin-4(1H)-one, and its subsequent treatment with aqueous sulfuric acid. Formula (I).

专利号:EP-3759082-B1
优先权日:2018-02-28
标题 :Process for the synthesis of 6-chloromethyluracil

专利号:IT-201800003134-A1
优先权日:2018-02-28
标 题:PROCESS FOR THE SYNTHESIS OF 6-CHLOROMETHYLURACIL

专利号:US-2020407330-A1
优先权日:2018-02-28
标 题:Process for the synthesis of 6-chloromethyluracil

专利号:EP-3759082-A1
优先权日:2018-02-28
标题:Process for the synthesis of 6-chloromethyluracil

专利号:JP-7379346-B2
优先权日:2018-02-28
标题 :Synthesis method of 6-chloromethyluracil