CAS: 61641-47-2; 5(R)-Hete

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CAS号82200-87-1 5(S),15(S)-二羟化二十烷四烯酸

📜(Z,Z)-1-Iodo-3,6-Dodecadiene置于正丁基锂,Potassium Carbonate体系中,用 四氢呋喃,甲醇,六甲基磷酰三胺,水,甲苯 作为反应溶剂,化学反应生成 5(R)-羟化二十烷四烯酸
参考文献:Stereospecific Synthesis Of 5S-Hete,5R-Hete And Their Transformation To 5(+/-)Hpete
标题:Stereospecific Synthesis Of 5S-Hete,5R-Hete And Their Transformation To 5(+/-)Hpete
摘要:
DOI:10.1016/s0040-4039(00)81586-5

专利信息

专利号:WO-2011131619-A1
优先权日:2010-04-21
标题:Method of synthesizing a 5-oxo-conjugated fatty acid
发明人：ULVEN TROND; TYAGI RAHUL
权利人:UNIV SYDDANSK; ULVEN TROND; TYAGI RAHUL
摘要:There is provided a novel chemical synthetic method for the preparation of a 5-oxo-ETE and related compounds. The method is based on a short and efficient synthesis of 5-oxo-ETE from commercially available Arachidonic acid. The method is based on the surprising discovery that a 5-oxo-conjugated fatty acid may be efficiently converted into the corresponding 5-oxo-conjugated fatty acid by reaction with the Dess-Martin reagent (1,1,1-triacetoxy-1,1-dihydro-1,2-benziodoxol-3(1H)-one)in the presence of pyridine or a substituted pyridine.

专利号:US-5446062-A
优先权日:1993-11-12
标 题:((4-alkoxypyran-4-yl) substituted) ether, arylalkyl-, arylalkenyl-, and arylalkynyl)urea inhibitors of 5-lipoxygenase
发明人：DELLARIA JOSEPH F; BASHA ANWER; BLACK LAWRENCE A; CHERNESKY LINDA J; LEE WENDY
权利人:ABBOTT LAB
摘要:Compounds of the structure where W is selected from where Q is oxygen or sulfur, R6 and R7 are hydrogen or alkyl, or R6 and R7, together with the nitrogen atoms to which they are attached, define a radical of formula Z is -CH2-, oxygen, sulfur, or -NR9, L1 and L2 are selected from a valence bond, alkylene, propenylene, and propynylene; R1 and R2 are independently selected from alkyl, alkoxy, haloalkyl, halogen, cyano, amino, alkoxycarbonyl, and dialkylaminocarbonyl; Y is selected from oxygen, >NR10, and L3 is selected from alkylene of one to three carbon atoms, propenylene, propynylene, and R3, R4, and R5 are hydrogen or alkyl of one to four carbon atoms inhibit the synthesis of leukotrienes. These compounds are useful in the treatment or amelioration of allergic and inflammatory disease states.

专利号:US-5530114-A
优先权日:1990-04-30
标 题:Oligonucleotide modulation of arachidonic acid metabolism
发明人：BENNETT CLARENCE F; ECKER DAVID J; CROOKE STANLEY T; MIRABELLI CHRISTOPHER K
权利人:ISIS PHARMACEUTICALS INC
摘要:PCT No. PCT/US91/02628 Sec. 371 Date Apr. 3, 1992 Sec. 102(e) Date Apr. 3, 1992 PCT Filed Apr. 17, 1991 PCT Pub. No. WO91/16901 PCT Pub. Date Nov. 14, 1991.Compositions and methods are provided for the treatment and diagnosis of diseases amenable to modulation of the synthesis or metabolism of arachidonic acid and related compounds. In accordance with preferred embodiments, oligonucleotides and oligonucleotide analogs are provided which are specifically hybridizable with nucleic acids encoding 5-lipoxygenase, 5-lipoxygenase activating proteins, LTA4 hydrolase, phospholipase A2, phospholipase C, and coenzyme A-independent transacylase. The oligonucleotide comprises nucleotide units sufficient in identity and number to effect said specific hybridization. In other preferred embodiments, the oligonucleotides are specifically hybridizable with a transcription initiation site, a translation initiation site, and intron/exon junction. Methods of treating animals suffering from disease amenable to therapeutic intervention by modulating arachidonic acid synthesis or metabolism with an oligonucleotide or oligonucleotide analog specifically hybridizable with RNA or DNA corresponding to one of the foregoing proteins are disclosed. Methods for treatment of diseases responding to modulation of arachidonic acid synthesis or metabolism are disclosed.

专利号:US-4665092-A
优先权日:1985-10-03
标 题 :Styrene derivatives, their use as antiallergic agents and intemediate epoxides for their synthesis
发明人：FERRO MICHAEL P; WACHTER MICHAEL P
权利人:ORTHO PHARMA CORP
摘要:Alkenes of the formula (I) and epoxides (II) used to make them are useful as anti-inflammatory and antiallergic pharmaceuticals: ##STR1## wherein R 1 =H or CH 3 ; R 2 =phenyl, substituted phenyl, benzyl or a cysteinyl moiety; R 4 and R 5 =alkyl; n=O or 1; and R 3 is as described.

专利号:US-4814487-A
优先权日:1986-09-26
标 题:Amido substituted naphthalenes and intermediates thereof
发明人：MURRAY WILLIAM V; WACHTER MICHAEL P
权利人:ORTHO PHARMA CORP
摘要:The synthesis of amido substituted naphthalenes and their intermediates is described. The intermediates and amido substituted naphthalenes are useful as anti-inflammatory agents.

专利号:US-8877476-B2
优先权日:2010-06-01
标 题 :Soluble and stable human 5-lipoxygenase
发明人：NEWCOMER MARCIA E; BARTLETT SUE G; GILBERT NATHANIEL C
权利人:NEWCOMER MARCIA E; BARTLETT SUE G; GILBERT NATHANIEL C; UNIV LOUISIANA STATE
摘要:A soluble and stable form of 5-lipoxygenase (5-LOX) has been made, 5-Lox is the enzyme which initiates leukotriene biosynthesis by catalyzing the two-step transformation of arachidomc acid to leukotriene A4 (LTA4). The soluble and stable 5-LOX is suitable for a number of applications, including, but not limited to, high throughput screening of 5-LOX inhibitors, structural analysis of the enzyme's active site, designing inhibitors based on the three-dimensional structure of the enzyme's active site, and synthesis of LTA4. Using Stable-5-LOX, the crystal structure for 5-LOX has been resolved and the amino acids defining the active site determined.