CAS: 59080-45-4; (2R,3R,4S,5S,6R)-2-(Hexyloxy)-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-3,4,5-Triol

该化合物是一种非离子表面活性剂和由葡萄糖衍生的胶质,其特征是附于-D-甘基丙诺斯非美美化碳的六氟基乙醇组,该组有助于其非非双光性性质,使其在水和有机溶剂中都可溶解.该组通常用于生物化学和生物物理研究,特别是用于膜蛋白研究,因为它能够稳定蛋白并便利其溶解.Hexyl-D-gluclocalarside 表现出低毒性,并且可以生物降解,因此与其他表面活性剂相比,它是一种无害环境的选择.其特性包括相对重要的小鼠浓度(CMC),对于涉及小鼠形成的应用非常重要.此外,它可以影响生物膜的行为,使其在药物运载系统中有用,并作为各种实验室应用的工具.

结构式图片

上下游产品

D-glucose hexan-1-ol hexan-1-ol 2,3,4,6-tetra-O-acetyl-β-D-glucopyranoside D-GlucoseD-Mannose (2R,3S,4S,5R,6R)-2-Hydroxymethyl-6-nonyloxy-tetrahydro-pyran-3,4,5-triol β-D-glucose hexan-1-ol

合成工艺路线路线简述

    📜戊基beta-D-吡喃葡萄糖苷置于almond Meal体系中,用 水 作为反应溶剂,化学反应 336.0H,反应生成 己基β-D-吡喃葡萄糖苷
    参考文献:Significantly Improved Equilibrium Yield Of Long-Chain Alkyl Glucosides Via Reverse Hydrolysis In A Water-Poor System Using Cross-Linked Almond Meal As A Cheap And Robust Biocatalyst
    标题:Significantly Improved Equilibrium Yield Of Long-Chain Alkyl Glucosides Via Reverse Hydrolysis In A Water-Poor System Using Cross-Linked Almond Meal As A Cheap And Robust Biocatalyst
    摘要:An Array Of Ten Beta-D-Glueopyranosides With Varied Alkyl Chain Lengths Were Enzymatically Synthesized. It Was Found That For Longer Alkyl Chains A Lower Initial Rate And Final Yield Of Glucoside Was Obtained Except For Methyl Glucoside Because Of The Severe Toxicity Of Methanol To The Enzyme. From A Thermodynamics Point Of View,The Equilibrium Constant And Gibbs Free Energy Variation Of The Glucoside Syntheses Were Systematically Investigated. To Improve The Final Yields Of The Glucosides Containing Long Alkyl Chains The Equilibrium Of The Enzymatic Glucoside Synthesis Was Altered. The Equilibrium Yield Of Decyl Beta-D-Glucoside Increased From 1.9% To 6.1% When The Water Content Was Reduced From 10% To 5% (V/v) Using Tert-Butanol As A Cosolvent And 0.10 Mol/l Of Glucose As A Substrate. As For The Other Longer Alkyl Chain Glucosides,Heptyl Beta-D-Glucoside Was Found To Have Significant Surface Activity As Well.
    DOI:10.1016/s1872-2067(11)60333-1

    海关参考信息

    专利信息


    专利号:US-2006211083-A1
    优先权日:2005-01-21
    标题:Products and processes for in vitro synthesis of biomolecules
    发明人:KATZEN FEDERICO; KUDLICKI WIESLAW; FLETCHER JULIA
    权利人:KATZEN FEDERICO; KUDLICKI WIESLAW; FLETCHER JULIA
    摘要:Provided herein are products and processes for efficiently synthesizing biomolecules in vitro using cell-free extracts derived from mammalian cells and insect cells. In an embodiment, provided is a process for preparing a cell-free extract from insect cells and mammalian cells that efficiently synthesizes post-translationally modified target proteins (e.g., glycosylated target proteins). In some embodiments, a ribonucleic acid is synthesized in vitro that comprises a cap, a 5′ untranslated region comprising an 18S rRNA binding ribonucleotide sequence, and a target ribonucleotide sequence. It has been determined that such ribonucleic acids result in efficient in vitro synthesis of a target protein using cell-free extracts derived from non-rabbit mammalian cells and insect cells.

    专利号:US-2001049117-A1
    优先权日:1998-08-20
    标 题 :Analogs of udp-murnac peptides, assays, kits and related methods of their use
    发明人:AXELROD HELENA R; BRANSTROM ARTHUR A
    摘要:General compositions and methods for detecting Lipid I, Lipid II and peptidoglycan synthesis is disclosed. A method of screening for potential antibacterial agents is provided which requires bacterial membrane preparations or enriched enzyme preparations including at least one bacterial enzyme involved in the synthesis of Lipid I from UDP-MurNAc pentapeptide and undecaprenyl phosphate, at least one bacterial enzyme involved in the synthesis of Lipid II from Lipid I and UDP-GlcNAc and one or more bacterial enzymes involved in the further processing of Lipid II toward the downstream synthesis of peptidoglycan. The methods disclosed herein further provides a labeled UDP-MurNAc-peptide capable of serving as a substrate for a bacterial enzyme involved in the synthesis of Lipid I and a labeled UDP-GlcNAc capable of serving as a substrate for a bacterial enzyme involved in the synthesis of Lipid II. Conditions for further processing of Lipid II toward the downstream synthesis of peptidoglycan are also discribed.

    专利号:WO-2006078821-A2
    优先权日:2005-01-21
    标题:Products and processes for in vitro synthesis of biomolecules

    专利号:US-2010055187-A1
    优先权日:2008-08-28
    标题:Nanovitamin synthesis
    发明人:AHN DONG JUNE
    权利人:AHN DONG JUNE
    摘要:Stable nanoparticulate vitamin compositions are prepared from agglomerated or larger sized vitamin particles of at least one vitamin compound by breaking down and/or solubilizing the agglomerated or larger sized vitamin particles and associating the particles with a surface modifying agent.

    专利号:US-2009028948-A1
    优先权日:2004-12-31
    标 题 :Nanoparticle composition and methods of synthesis thereof

    专利号:CN-111363770-A
    优先权日:2020-05-07
    标题:A kind of synthesis technology of surfactant hexyl glycoside

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    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    合成参考文献


    参考文献:10.1248/cpb.56.536
    摘要:Nakamura S, Li X, Matsuda H, Yoshikawa M. Bioactive constituents from Chinese natural medicines. XXVIII. Chemical structures of acyclic alcohol glycosides from the roots of Rhodiola crenulata. Chem Pharm Bull (Tokyo). 2008 Apr;56(4):536–40. doi: 10.1248/cpb.56.536.
    参考文献:10.1021/bi049106n
    摘要:Raja MM, Kipp H, Kinne RK. C-terminus loop 13 of Na+ glucose cotransporter SGLT1 contains a binding site for alkyl glucosides. Biochemistry. 2004 Aug 31;43(34):10944–51. doi: 10.1021/bi049106n.
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