CAS: 5734-63-4; 4-Methyl-6-(Trifluoromethyl)Pyrimidin-2-Amine

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📜4-Trifluoromethyl-6-Methyl-2-Acetylaminopyrimidine置于sodium Hydroxide体系中,用 乙醇 作为反应溶剂,化学反应 20.0H,以70%的收率获得产物2-氨基-4-三氟甲基-6-甲基嘧啶
参考文献:One‐pot Synthesis Of N 2 ‐aminoprotected 6‐substituted And Cycloalka[D] 4‐trifluoromethyl‐2‐acetylaminopyrimidines
标题:One‐pot Synthesis Of N 2 ‐aminoprotected 6‐substituted And Cycloalka[D] 4‐trifluoromethyl‐2‐acetylaminopyrimidines
摘要:Abstractmagnified Imagethe One‐pot Synthesis Of A Novel Series Of Amino‐protected 6‐alkyl‐,6‐aryl‐,6‐heteroaryl‐ And 5,6‐fused‐cycloalkane 4‐trifluoromethyl‐2‐acetylaminopyrimidines,Where Alkyl = Me; Aryl = Ph,4‐ch3Ph,4‐fph,4‐clph,4‐brph,4‐och3Ph,4‐no2Ph,4,4'‐biphenyl,1‐naphthyl; Heteroaryl = 2‐thienyl,2‐furyl And Cycloalkyl = C‐c6H4,C‐c7H5 From The Reaction Of Substituted 4‐methoxy‐1,1,1‐trifluoroalk‐3‐en‐2‐ones With 1‐acetylguanidine In Acetonitrile Or Propan‐2‐ol As Solvent,Is Reported. The Acetylamino Group Of 2‐acetylaminopyrimidines Was Hydrolyzed Under Three Different Conditions To Afford The Corresponding Free 2‐aminopyrimidines.
DOI:10.1002/jhet.5570450228