CAS: 56891-69-1; Ethyl 3-Cyano-2-Mercapto-6-Methylisonicotinate

相似化合物

90915-26-7 113858-90-5 929975-82-6

上下游产品

CAS号7357-70-2 2-氰基硫代乙酰胺 | CAS号615-79-2 乙酰丙酮酸乙酯 | CAS号40108-12-1 乙基2-氯-3-氰-6-甲基吡...

📜2-氯-3-氰基-6-甲基异烟酸乙酯置于硫脲体系中,用 乙醇 作为反应溶剂,化学反应 24.0H,以50%的收率获得产物3-氰基-2-巯基-6-甲基吡啶-4-甲酸乙酯
参考文献: Substituted 3-Amino-Thieno[2,3-B]Pyridine-2-Carboxylic Acid Amide Compounds And Processes For Preparing And Their Uses[fr] Composes Amide D'Acide 3-Amino-Thieno[2,3-B]Pyridine-2-Carboxylique Substitues Et Processus De Preparation Et D'Utilisation De Ces Composes
标题: Substituted 3-Amino-Thieno[2,3-B]Pyridine-2-Carboxylic Acid Amide Compounds And Processes For Preparing And Their Uses[fr] Composes Amide D'Acide 3-Amino-Thieno[2,3-B]Pyridine-2-Carboxylique Substitues Et Processus De Preparation Et D'Utilisation De Ces Composes
摘要:公开的是式(I)的化合物,其中r1和r2如本文所定义,这些化合物可用作iKb激酶(ikk)复合物激酶活性的抑制剂.因此,这些化合物在治疗ikk介导的疾病,包括自身免疫疾病,炎症性疾病和癌症方面是有用的.还公开了包含这些化合物的药物组合物以及制备这些化合物的方法.

专利信息

专利号:US-6531470-B1
优先权日:1998-01-23
标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:US-6562844-B2
优先权日:1998-01-23
标 题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:US-7002020-B1
优先权日:1998-01-23
标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.