CAS: 52705-43-8; Mono(α-Hydroxybenzyl)Phosphinic Acid

📜O-Trimethylsilyl [phenyl(Trimethylsiloxy)Methyl]Phosphonite置于水体系中,化学反应生成 Alpha-羟基苄基次亚磷酸
参考文献:Pudovik,A.N. Et Al.,Phosphorus And The Related Group V Elements,1975,Vol. 5,P. 105-107
标题:Pudovik,A.N. Et Al.,Phosphorus And The Related Group V Elements,1975,Vol. 5,P. 105-107

专利信息

专利号:US-6350595-B1
优先权日:1997-10-28
标题:Synthesis of polynucleotides having random sequences
发明人：NEUNER PHILIPPE
权利人:ISTITUTO DI RICERCHE DI MOLECO
摘要:Subject of this invention is a process for the chemical synthesis of polynucleotides having totally or partially random sequences, based on the utilization, as synthesis monomer units for the random sequence part, or presynthesized mononucleotides and dinucleotides. Said synthesis is carried out on separate supports, so that on each of those supports is alternated at least one reaction cycle wherein a mixture of said dinucleotides is bound, with at least one reaction cycle wherein a mononucleotide is bound, and that in a preferred embodiment at the end of the n cycles required for a codon synthesis, the supports are mixed and then redivided into one or more reaction containers. The resulting polynucleotides are such that, for the random sequence part, each trinucleotide unit is fit to match only a limited number of codons, predefined for each unity in number and sequence, and the genetic code degeneracy effects can thus be eliminated. FIG. 1 shows the chemical structure of the dinucleotides utilized as monomer units for the synthesis of codons forming the final sequence.

专利号:EP-0356880-A2
优先权日:1988-09-02
标题 :Process for the synthesis of tetraethyl ester of phosphonosuccinic acid
发明人：ODENBACH HERBERT DR; BLOCK HANS-DIETER DR; IMMENKEPPEL MICHAEL DR
权利人:BAYER AG
摘要:The present invention relates to an improved process for the synthesis of phosphonosuccinic acid tetramethyl ester and phosphonosuccinic acid tetraethyl ester in high yields and from easy-to-handle starting materials, in which dimethylphosphite or diethylphosphite is mixed with ethylenedicarboxylic acid dimethyl ester or ethylenedicarboxylic acid diethyl ester in a molar ratio of 1: 1 to 1: 1, with addition of 1: 1 to 1: 1 -10 mol% of methanolic sodium ethylate solution or ethanolic sodium ethylate solution, based on dialkyl phosphite, at temperatures of 30-120 ° C.

专利号:US-2023183246-A1
优先权日:2020-05-19
标题 :Continuous flow sonogashira coupling synthesis method
发明人：THOMPSON DAVID HARLEY; SINTIM HERMAN O; QI QINGQING; BIYANI SHRUTI
权利人:PURDUE RESEARCH FOUNDATION
摘要:The present disclosure relates to a telescoped continuous flow Sonogashira coupling synthesis for some lead compounds to support in vivo studies and pre-clinical evaluation. The application of high throughput tools combined with the telescoped continuous synthesis method can enable an efficient and safe synthesis of compounds of interest involving hazardous coupling reagents such as HATU, while minimizing by-product formation.

专利号:US-2008311580-A1
优先权日:2004-03-09
标 题:Novel genes encoding proteins involved in proanthocyanidin synthesis
发明人：ABRAHAMS SHARON; ASHTON ANTHONY RICHARD; TANNER GREGORY JOHN; LARKIN PHILIP JOHN
权利人:COMMW SCIENT IND RES ORG
摘要:This inventions provides an isolated protein or polypeptide having activity in the synthesis of proanthocyanidin (PA) polymer from epicatechin or catechin in plants, and which is not naturally regulated by the TT2 or TT8 regulators, or a fragment comprising at least about 10 contiguous amino acids derived from said protein or polypeptide, particularly TDS1, TDS2, TDS3, TDS4, TDS5, or TDS6 protein, or fragment thereof. n Also provided are nucleic acid encoding such proteins or polypeptides; plant cells and plants containing and expressing such nucleic acids; antibodies that bind to such proteins or polypeptides; and related methods.

专利号:US-9783634-B2
优先权日:2012-02-15
标题 :Synthesis of photovoltaic conjugated polymers
发明人：WANG SHUANGXI; SHI CHENJUN; CHEN RUBY; ZHANG JUNLIAN; WANG WEI; WU YUE; HUANG HUI; PALKAR AMIT; HE TING
权利人:PHILLIPS 66 CO; SOLARMER ENERGY INC
摘要:A method of making a fluorothieno[3,4-b]thiophene derivatives and photovoltaic polymers containing same using 3-bromothiophene-2-carboxylic acid as a starting material. This synthetic route provides an easier synthesis as well as greater yield and a purer product, which produces superior results over the prior art less pure products. The resulting materials can be used in a variety of photovoltaic applications and devices, especially solar cells.

专利号:US-6309842-B1
优先权日:1996-12-03
标 题:Use of modified tethers in screening compound libraries
发明人：DOWER WILLIAM J; GATES CHRISTIAN M; HEINKEL GREGORY L; LALONDE GUY; MATTHEAKIS LARRY C; PADDON CHRISTOPHER J; SCHATZ PETER J
权利人:GLAXO WELLCOME INC
摘要:The invention provides methods for screening libraries of complexes for compounds having a desired property, especially, the capacity to agonize, bind to, or antagonize a cellular receptor. The complexes in such libraries comprise a compound under test, a tag recording at least one step in synthesis of the compound, and a tether susceptible to modification by a reporter molecule. Modification of the tether is used to signify that a complex contains a compound having a desired property. The tag can be decoded to reveal at least one step in the synthesis of such a compound.