📜Eupha-8,24-Diene-3β-Ol-7-One置于甲醇,Sodium Tetrahydroborate体系中,化学反应生成 大戟二烯醇 参考文献: Process For The Preparation Of Lanosta-8-Ene Compou[fr] Procédé De Préparation De Composés Lanosta-8-ènes 标题: Process For The Preparation Of Lanosta-8-Ene Compou[fr] Procédé De Préparation De Composés Lanosta-8-ènes 摘要:本发明涉及一种以lanosta-8-Ene-7-One或lanosta-8-Ene-7-Ol化合物为起始原料制备lanosta-8-Ene化合物的方法.
专利号:WO-2020121335-A1 优先权日:2018-12-14 标题:A process for producing tirucalladienol for synthesis of limonoids 发明人:HIREKODATHAKALLU VENKATARAMAIAH THULASIRAM; PANDREKA AVINASH; PATIL CHAYA SHIVANAGOUDA 权利人:COUNCIL SCIENT IND RES 摘要:The invention relates to the construction of recombinant DNA constructs encoding tirucalladienol synthase; and squalene epoxidase operably linked to a regulatory sequence. The production of tricualldienol in a yeast is increased by coexpression with squalene epoxidase. Further, tirucalladeinol synthase engineering leads to increase in the efficiency of the synthesis process towards tirucalladienol.
专利号:US-2019029993-A1 优先权日:2017-07-26 标 题 :Quality of life extension therapies relating to aging, food allergies, pain and reduced vigor by managing molecular, cellular and subcellular biochemical requirements of mitochondria and other organelle processes 发明人:POSTREL RICHARD 权利人:POSTREL RICHARD 摘要:This invention provides compositions, systems and methods that improve and/or optimize the health and performance of animals, especially mammals including humans, canines, equines, felines, etc. Key aspects of the principle invention and its parts include the monitoring, management and modulation of the body's natural cannabinoid systems through its native mechanisms thereby optimizing its processes by supplementation with endogenously occurring components and/or by administering synthetic compounds. The invention selects from multiple available resources to modify and/or rebalance an individual system or it may be applied across interconnected systems. The encompassing system that is intricately involved in the operations and intensities, e.g., the balancing of most other systems of our bodies, relates to cannabinoid compounds and their receptors. The cannabinoid pathways can be coordinated in rebalancing multiple and various metabolic pathways. Compositions comprising compounds that slow degradation of native endocannabinoids, that stimulate their production and/or compounds that act on cannabinoid receptors within the body are featured in systems and methods of this invention. The activated and rebalanced cannabinoid systems then become adept at modulating and the rebalancing of the numerous systems in which they participate to improve one or more systems including, but not limited to: normal and/or abnormal stresses of life, environmental influences, genomic or epigenomic irregularities and/or normal or accentuated processes of aging. Specifically targeted systems may include, but are not limited to, those involved in: cellular and/or mitochondrial metabolism, corticosteroid synthesis and effects, appetite, allergy and immunity, sleep and waking, etc. Practicing the invention selects from multiple approaches that may be used independently or in concert to compensate for a variety of concerns. Supplementing dietary intake to rebalance metabolism and/or its metabolic responses—including immunogenic or allergic responses to pathogenic and/or environmental stresses is one focus. Additional features of the invention may include: compensating for failing or decreasing androgen hormone levels as an animal continues to age, rebalancing the organism's metabolism through providing mitochondrial supplements, and serially revisiting effects of the early stages of treatment to redirect or improve activity of all aspects of life and metabolism.
专利号:US-2019030044-A1 优先权日:2017-07-26 标 题:Human life extension therapy through molecular, cellular and subcellular management of biochemical requirements of mitochondria and of other organelle processes associated with the advent of disease and/or aging 发明人:POSTREL RICHARD 权利人:POSTREL RICHARD 摘要:This invention provides compositions, systems and methods that improve and/or optimize the health and performance of animals, especially mammals including humans, canines, equines, felines, etc. Key aspects of the principle invention and its parts include the monitoring, management and modulation of the body's natural cannabinoid systems through its native mechanisms thereby optimizing its processes by supplementation with endogenously occurring components and/or by administering synthetic compounds. The invention selects from multiple available resources to modify and/or rebalance an individual system or it may be applied across interconnected systems. The encompassing system that is intricately involved in the operations and intensities, e.g., the balancing of most other systems of our bodies, relates to cannabinoid compounds and their receptors. The cannabinoid pathways can be coordinated in rebalancing multiple and various metabolic pathways. Compositions comprising compounds that slow degradation of native endocannabinoids, that stimulate their production and/or compounds that act on cannabinoid receptors within the body are featured in systems and methods of this invention. The activated and rebalanced cannabinoid systems then become adept at modulating and the rebalancing of the numerous systems in which they participate to improve one or more systems including, but not limited to: normal and/or abnormal stresses of life, environmental influences, genomic or epigenomic irregularities and/or normal or accentuated processes of aging. Specifically targeted systems may include, but are not limited to, those involved in: cellular and/or mitochondrial metabolism, corticosteroid synthesis and effects, appetite, allergy and immunity, sleep and waking, etc. Practicing the invention selects from multiple approaches that may be used independently or in concert to compensate for a variety of concerns. Supplementing dietary intake to rebalance metabolism and/or its metabolic responses—including immunogenic or allergic responses to pathogenic and/or environmental stresses is one focus. Additional features of the invention may include: compensating for failing or decreasing androgen hormone levels as a human continues to age, rebalancing the organism's metabolism through providing mitochondrial supplements, and serially revisiting effects of the early stages of treatment to redirect or improve activity of all aspects of life and metabolism.
专利号:CN-108477167-A 优先权日:2018-03-26 标题:A method for promoting the synthesis of terpenoids in Kansui
专利号:US-2020078333-A1 优先权日:2016-12-21 标 题 :Healthier Aging in Domesticated Animals 发明人:POSTREL RICHARD 权利人:POSTREL RICHARD 摘要:This invention provides compositions, systems and methods that improve and/or optimize the health and performance of animals, especially mammals including humans, canines, equines, felines, etc. Key aspects of the principle invention and its parts include the monitoring, management and modulation of the body's natural cannabinoid systems through its native mechanisms thereby optimizing its processes by supplementation with endogenously occurring components and/or by administering synthetic compounds. The invention selects from multiple available resources to modify and/or rebalance an individual system or it may be applied across interconnected systems. The encompassing system that is intricately involved in the operations and intensities, e.g., the balancing of most other systems of our bodies, relates to cannabinoid compounds and their receptors. The cannabinoid pathways can be coordinated in rebalancing multiple and various metabolic pathways. Compositions comprising compounds that slow degradation of native endocannabinoids, that stimulate their production and/or compounds that act on cannabinoid receptors within the body are featured in systems and methods of this invention. The activated and rebalanced cannabinoid systems then become adept at modulating and the rebalancing of the numerous systems in which they participate to improve one or more systems including, but not limited to: normal and/or abnormal stresses of life, environmental influences, genomic or epigenomic irregularities and/or normal or accentuated processes of aging. Specifically targeted systems may include, but are not limited to, those involved in: cellular and/or mitochondrial metabolism, corticosteroid synthesis and effects, appetite, allergy and immunity, sleep and waking, etc. Practicing the invention selects from multiple approaches that may be used independently or in concert to compensate for a variety of concerns. Supplementing dietary intake to rebalance metabolism and/or its metabolic responses—including immunogenic or allergic responses to pathogenic and/or environmental stresses is one focus. Additional features of the invention may include: compensating for failing or decreasing androgen hormone levels as an animal continues to age, rebalancing the organism's m
专利号:CN-105246866-B 优先权日:2013-05-31 标题:The method of synthesis ingenol and its intermediate
1: Dutra RC, Bicca MA, Segat GC, Silva KA, Motta EM, Pianowski LF, Costa R, Calixto JB. The antinociceptive effects of the tetracyclic triterpene euphol in inflammatory and neuropathic pain models: The potential role of PKCε. Neuroscience. 2015 Sep 10;303:126-37. doi: 10.1016/j.neuroscience.2015.06.051. Epub 2015 Jul 2. doi: 10.1371/journal.pone.0140249. eCollection 2015. 3: Xie X, Li Y, Gao D, Zhang Y, Ren Y. Quantitative determination of euphol in rat plasma by LC-MS/MS and its application to a pharmacokinetic study. Biomed Chromatogr. 2014 Sep;28(9):1229-34. doi: 10.1002/bmc.3151. doi: 10.3892/mmr.2013.1650. Epub 2013 Aug 22. doi: 10.4103/0974-8490.147136. 6: Singh GB, Singh S, Sharma ML, Suri OP, Chopra CL, Ammon HP. Hypotensive activity of 8,24-euphadien-3 beta-ol (euphol). Planta Med. 1989 Dec;55(6):498-500. doi: 10.1016/j.jep.2016.02.025. Epub 2016 Feb 22. doi: 10.1055/s-0034-1368300. Epub 2014 Mar 31. doi: 10.1016/j.jep.2013.08.033. Epub 2013 Sep 2. Chinese. doi: 10.1016/j.chembiol.2009.09.012.