CAS: 51146-57-7; (R)-2-(4-Isobutylphenyl)Propanoic Acid

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CAS号6448-14-2 N-[3-[(3-propox... | CAS号15687-27-1 布洛芬 | CAS号62784-66-1 二-1-萘甲醇 | CAS号110282-71-8 Bis(phenanthren... | CAS号1187670-13-8 (R)-ibuprofen d... | CAS号51407-46-6 2-(4-异丁基苯基)丙醛 | CAS号61566-34-5 甲基-2 -(4-异丁基苯基)丙酸 | CAS号298197-67-8 1,1-bis(trimeth... | CAS号2039-82-9 对溴苯乙烯 | CAS号34352-86-8 1-(2-methylprop...

📜布洛芬置于(R)-Binol-Sncl4,Lithium Diisopropyl Amide体系中,用 四氢呋喃,二氯甲烷,甲苯 作为反应溶剂,化学反应 3.5H,反应生成 (R)-(-)-布洛芬
参考文献:用路易斯酸辅助的手性布朗斯台德酸对甲硅烷基烯醇醚和乙烯酮二甲硅烷基缩醛进行对映选择性质子化:反应范围和机理见解
标题:用路易斯酸辅助的手性布朗斯台德酸对甲硅烷基烯醇醚和乙烯酮二甲硅烷基缩醛进行对映选择性质子化:反应范围和机理见解
摘要:对映选择性质子化是构建手性碳的有效方法.在这里,我们报告了使用路易斯酸辅助手性布朗斯台德酸(手性 Lba)的反应细节.四氯化锡与光学活性联萘酚((R)-或(S)-Binol)的1:1配位络合物可直接质子化各种甲硅烷基烯醇醚和乙烯酮二甲硅烷基缩醛,得到相应的α-芳基酮和α-芳基羧酸,分别具有高对映体过量(高达 98% Ee).在四氯化锡存在下,使用化学计量量的 2,6-二甲基苯酚和催化量的光学活性 Binol 的单甲醚也实现了对映选择性质子化的催化形式.这种质子化对于生产 α-卤代羰基化合物也很有效(高达 91% Ee).
DOI:10.1021/ja001164I

专利信息

专利号:US-5726301-A
优先权日:1992-04-24
标题 :CAC H-phosphonate and its use in the synthesis of oligonucleotides
发明人：REDDY M PARAMESWARA; HANNA NAEEM B; FAROOQUI FIRDOUS
权利人:BECKMAN INSTRUMENTS INC
摘要:Disclosed herein are N4 protected deoxycytidines for use in the synthesis of oligonucleotides, the protecting groups being represented by the formula: -CO-(CH2)0-9-CH3. Preferred embodiments are N4 acetyl deoxycytidines and include N4 acetyl deoxycytidine phosphoramidites and N4 acetyl deoxycytidine H-phosphonates. When used to prepare oligonucleotides the protected deoxycytidine compounds provide high quality oligonucleotide products with little side product from cleavage and deprotection reactions carried out with alkyl amine compounds.

专利号:US-5248815-A
优先权日:1991-12-27
标 题 :Stereo-selective synthesis of 2-aryl-propionic acids of high optical purity by using chiral oxazolines
发明人：PARADIES HENRICH H
权利人:PARADIES HENRICH H
摘要:The present invention relates to a stereospecific chemical synthesis of optically pure enantiomers of 2-aryl-alkanoic acids, especially those of the biologically active (S)-aryl-propionic acids, in good chemical yields, useful for preparing large quantities thereof, and having a high optical purity.

专利号:WO-2013178803-A1
优先权日:2012-05-31
标 题:Process and apparatus for the electrolytic synthesis of methanol and/or methane
发明人：SCHAEL OLIVER; BURMEISTER GUIDO
权利人:HETTICH HOLDING GMBH & CO OHG
摘要:The invention relates to a process for the electrolytic synthesis of methanol by reduction of carbon dioxide present in an electrolyte in the liquid phase, at the critical point or in the supercritical phase of the electrolyte. The process is characterized in that protons for the reduction of the carbon dioxide are introduced into the electrolyte via a proton-conducting membrane (2). The invention further relates to an apparatus suitable for carrying out the process.

专利号:US-6090934-A
优先权日:1996-10-20
标 题:Universal support for the synthesis of oligonucleotides
发明人：KUMAR PRADEEP; GUPTA KAILASH CHAND
权利人:COUNCIL SCIENT IND RES; DBT GOVERNMENT OF INDIA
摘要:A universal polymer support containing an organic aliphatic molecule of structure ##STR1## having at least a pair of cis-hydroxyl groups where one of the hydroxyl groups is attached to the polymer support through a covalent linkage and the other hydroxyl group is protected by an acid labile group.

专利号:US-5428148-A
优先权日:1992-04-24
标 题 :N4 - acylated cytidinyl compounds useful in oligonucleotide synthesis
发明人：REDDY PARAMESWARA M; HANNA NAEEM B
权利人:BECKMAN INSTRUMENTS INC
摘要:Disclosed herein are protecting groups for exocyclic amino groups of the bases adenine, guanine and cytosine for use in the synthesis of oligonucleotides, the protecting groups being represented by the formula: -CO- (CH2)0-9-CH3. In a particularly preferred embodiment, the base cytosine is protected with acetyl (-CO-CH3), and the oligonucleotide incorporating said protected cytosine is subjected to a cleavage/deprotection reagent comprising at least one straight chain alkylamine having from 1 to about 10 carbon atoms.

专利号:US-2012149888-A1
优先权日:2009-02-22
标 题:Synthesis of ara-2'-o-methyl-nucleosides, corresponding phosphoramidites and oligonucleotides incorporating novel modifications for biological application in therapeuctics, diagnostics, g- tetrad forming oligonucleotides and aptamers
发明人：SRIVASTAVA SURESH C; PANDEY DIVYA; SRIVASTAVA NAVEEN P; SRIVASTAVA ALOK
权利人:SRIVASTAVA SURESH C; PANDEY DIVYA; SRIVASTAVA NAVEEN P; SRIVASTAVA ALOK
摘要:The present invention relates to synthesis, purification and methods to obtain high purity novel 2′-arabino-O-methyl nucleosides and the corresponding phosphoramidites of various arabinonucleoside bases and introduction of such units into defined sequence synthetic DNA and RNA. Various synthetic oligonucleotides, such as HIV integrase inhibitor 14-mer and thrombin binding oligonucleotide, thrombin-1, bearing ara-2′-omethyl modification have been synthesized. It is anticipated the oligonucleotides incorporating these monomers will exhibit biological activities related to antisense approach approach, design of better SiRNA's, diagnostic agents. Similarly, it is anticipated that oligonucleotides incorporating such novel nucleosides will be useful to develop therapeutic candidates designing stable G-quadruplexes and Aptamers for oligonucleotide structure, folding topology, evaluation of biochemical properties and design and develop as therapeutic agents. It is further anticipated that the nucleosides, phosphates and triphosphates of this invention could develop as therapeutic agents.