CAS: 42330-59-6; 2-Chloro-3-Pyridinylmethanol

相似化合物

1452-94-4 2942-59-8 36404-88-3

上下游产品

2-chloropyridine N-methoxy-N-methylbenzamide diisopropylamine 3-chloro-N-methoxy-N-methylbenzamide 2-chloro-3-chloromethyl-pyridine hydr°Chloride 2-chloro-3-carbaldehydepyridine C-(2-chloro-pyridin-3-yl)-methylamine [2-(3-benzyl-phenyl)-2-oxo-ethyl]-(2-chloro-pyridin-3-ylmethyl)-carbamic acid benzyl ester

2-氯烟酸置于sodium Tetrahydroborate,氯化亚砜体系中,用 水 作为反应溶剂,化学反应 1.5H,反应生成 2-氯-3-吡啶甲醇
参考文献:通过分子内的1,3-偶极环加成反应合成1,8-萘啶-5-酮衍生物
标题:通过分子内的1,3-偶极环加成反应合成1,8-萘啶-5-酮衍生物
摘要:1,8-萘啶-5-酮衍生物[(5,6,7,8-四氢-(3-氯-6-羟甲基-8-甲基)-1,8-萘啶-5-酮(9)]从2-氯烟酸开始,以分子内的1,3-偶极环加成反应为关键步骤进行了描述.
DOI:10.1002/jhet.5570320531

专利信息

专利号:US-2022056008-A1
优先权日:2018-12-21
标 题:Process and intermediates for the synthesis of voxelotor
发明人：FERREIRO GIL JUAN JOSÉ; IGLESIAS RETUERTO JESÚS MIGUEL; LORENTE BONDE-LARSEN ANTONIO
权利人:CRYSTAL PHARMA SAU
摘要:The invention relates to a process for the preparation of Voxelotor, or a salt or solvate thereof, according to the following scheme (Formula 1).

专利号:IL-284406-B2
优先权日:2016-05-12
标 题 :A process for the synthesis of 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)-pyridin-3-yl)methoxy)benzaldehyde

专利号:IL-297055-B1
优先权日:2016-05-12
标题 :A process for the synthesis of 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)-pyridin-3-yl)methoxy)benzaldehyde

专利号:IL-297055-A
优先权日:2016-05-12
标 题:A process for the synthesis of 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)-pyridin-3-yl)methoxy)benzaldehyde

专利号:EA-037014-B1
优先权日:2016-05-12
标题:METHOD FOR SYNTHESIS OF 2-HYDROXY-6 - ((2- (1-ISOPROPYL-1H-PYRAZOL-5-YL) PYRIDIN-3-YL) METHOXY) BENZALDEHYDE

专利号:WO-2020127945-A1
优先权日:2018-12-21
标 题 :Process and intermediates for the synthesis of voxelotor