📜<1,3-Dimethyl-2,4(1H,3H)-Dioxopyrimidin-5-Yl>Mercuric Acetate置于碘,Potassium Iodide体系中,化学反应 0.5H,以87.5%的收率获得产物5-碘-1,3-的甲基尿嘧啶 参考文献:Skulski,Lech; Kujawa,Anna; Kujawa,Tadeusz M.,Bulletin Of The Polish Academy Of Sciences: Chemistry,1987,Vol. 35,# 11-12,P. 499-505 标题:Skulski,Lech; Kujawa,Anna; Kujawa,Tadeusz M.,Bulletin Of The Polish Academy Of Sciences: Chemistry,1987,Vol. 35,# 11-12,P. 499-505
专利信息
专利号:US-2015239796-A1 优先权日:2014-02-19 标题:One pot synthesis of 18f labeledtrifluoromethylated compounds with difluoro(iodo)methane 发明人:RüHL THOMAS; RISS PATRICK; RAFIQUE WAQAS 权利人:UNIV OSLO 摘要:The present invention relates to compositions and methods for the synthesis of 18 F labeled compounds. In particular, the present invention relates to a copper (I) mediated one pot method for 18 F-trifluoromethylation of aromatic- or heteroaromatic halides with difluoro(iodo)methane (e.g., for use at PET imaging agents).
专利号:US-7122694-B2 优先权日:1998-11-06 标 题 :Hydroboronation process 发明人:MARCUCCIO SEBASTIAN MARIO; RODOPOULOS MARY; WEIGOLD HELMUT 权利人:BORON MOLECULAR PTY LTD 摘要:The invention relates to processes for the synthesis of aryl or alkene borates which comprises reacting: (i) an olefinic compound having a halogen or halogen-like substituent in a vinylic substitution position, or (ii) an aromatic ring having a halogen or halogen-like substituent in a ring substitution position, with a disubstituted monohydroborane in the presence of a Group 8-11 metal catalyst. The invention also relates to the use of these borates in coupling reactions. The invention further relates to certain disubstituted monohydroboranes and aryl or alkene borates.
专利号:US-8865898-B2 优先权日:2010-11-30 标题:Nucleoside analog or salt thereof, oligonucleotide analog, gene expression inhibitor, and nucleic-acid probe for detecting gene 发明人:UENO YOSHIHITO 权利人:UENO YOSHIHITO; JAPAN SCIENCE & TECH AGENCY 摘要:A nucleoside analog and a salt thereof represented by any of the general formulae (1) to (10) below: n nwherein R 1 , R 2 , and R 3 are the same or different groups, and each of the R 1 , R 2 and R 3 is selected from a hydrogen atom, a protecting group for a functional group in nucleic acid synthesis, a phosphate group, a phosphate group protected by a protecting group in nucleic acid synthesis, and an activated phosphate group for solid phase synthesis; and Ar is one of an aromatic hydrocarbon group and a polyaromatic hydrocarbon group.
[参考文献]: Yves M Dupertuis, Et Al. Unlabelled Iododeoxyuridine Increases The Rate Of Uptake Of [125I]Iododeoxyuridine In Human Xenografted Glioblastomas. Eur J Nucl Med Mol Imaging. 2002 Apr;29(4):499-505.
合成参考文献
参考文献:10.1055/s-0028-1083548 摘要:Mutsumi T, Maruhashi K, Monguchi Y, Sajiki H. Alternative I-D Exchange Reaction on Pyrimidine and Purine Nuclei Mediated by Tributyltin Hydride Using THF-d8 as a Deuterium Source. Synlett. 2008 Oct 15;2008(18):2811–4. doi: 10.1055/s-0028-1083548.