CAS: 40738-83-8; 5-Iodo-1,3-Dimethylpyrimidine-2,4(1H,3H)-Dione

该化合物是一种卤化衍生物,一种火利基,一种火利基核糖基,这种化合物的特点是5位置的碘原子,以及1和3角的聚氨环的两个甲基组.它的分子结构有助于其独特的化学特性,包括它作为核素的类似物,它有可能干扰核酸合成.碘原子的存在会加强其亲脂性,有可能影响其生物活动以及与酶或受体的相互作用.5-Iodo-1,3-二甲基尿素可能会产生多种药理效应,使其对医药化学和药物开发感兴趣.此外,其有机溶剂的稳定性和溶解性会影响其在研究和工业中的应用.与许多卤化化合物一样,它必须谨慎地处理,因为潜在的毒性和环境影响.总的来说,这种化合物会放大核糖核糖基在研究其生物功能和治疗潜力方面可能做出的各种改变.

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相似化合物

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上下游产品

CAS号874-14-6 1,3-二甲基尿嘧啶 | CAS号696-07-1 5-碘尿嘧啶 | CAS号74-88-4 碘甲烷 | CAS号77-78-1 硫酸二甲酯 | CAS号65904-27-0 (1,3-dimethyl-1... | CAS号105183-69-5 1,3-dimethyl-5-... | CAS号874-14-6 1,3-二甲基尿嘧啶 | CAS号4401-71-2 1,3,5-三甲基嘧啶-2,4... | CAS号85199-75-3 1,3-dimethyl-5-... | CAS号62803-31-0 1,3-dimethyl-5-...

合成工艺路线路线简述

    📜<1,3-Dimethyl-2,4(1H,3H)-Dioxopyrimidin-5-Yl>Mercuric Acetate置于碘,Potassium Iodide体系中,化学反应 0.5H,以87.5%的收率获得产物5-碘-1,3-的甲基尿嘧啶
    参考文献:Skulski,Lech; Kujawa,Anna; Kujawa,Tadeusz M.,Bulletin Of The Polish Academy Of Sciences: Chemistry,1987,Vol. 35,# 11-12,P. 499-505
    标题:Skulski,Lech; Kujawa,Anna; Kujawa,Tadeusz M.,Bulletin Of The Polish Academy Of Sciences: Chemistry,1987,Vol. 35,# 11-12,P. 499-505

    专利信息


    专利号:US-2015239796-A1
    优先权日:2014-02-19
    标题:One pot synthesis of 18f labeledtrifluoromethylated compounds with difluoro(iodo)methane
    发明人:RüHL THOMAS; RISS PATRICK; RAFIQUE WAQAS
    权利人:UNIV OSLO
    摘要:The present invention relates to compositions and methods for the synthesis of 18 F labeled compounds. In particular, the present invention relates to a copper (I) mediated one pot method for 18 F-trifluoromethylation of aromatic- or heteroaromatic halides with difluoro(iodo)methane (e.g., for use at PET imaging agents).

    专利号:US-7122694-B2
    优先权日:1998-11-06
    标 题 :Hydroboronation process
    发明人:MARCUCCIO SEBASTIAN MARIO; RODOPOULOS MARY; WEIGOLD HELMUT
    权利人:BORON MOLECULAR PTY LTD
    摘要:The invention relates to processes for the synthesis of aryl or alkene borates which comprises reacting: (i) an olefinic compound having a halogen or halogen-like substituent in a vinylic substitution position, or (ii) an aromatic ring having a halogen or halogen-like substituent in a ring substitution position, with a disubstituted monohydroborane in the presence of a Group 8-11 metal catalyst. The invention also relates to the use of these borates in coupling reactions. The invention further relates to certain disubstituted monohydroboranes and aryl or alkene borates.

    专利号:US-8865898-B2
    优先权日:2010-11-30
    标题:Nucleoside analog or salt thereof, oligonucleotide analog, gene expression inhibitor, and nucleic-acid probe for detecting gene
    发明人:UENO YOSHIHITO
    权利人:UENO YOSHIHITO; JAPAN SCIENCE & TECH AGENCY
    摘要:A nucleoside analog and a salt thereof represented by any of the general formulae (1) to (10) below: n nwherein R 1 , R 2 , and R 3 are the same or different groups, and each of the R 1 , R 2 and R 3 is selected from a hydrogen atom, a protecting group for a functional group in nucleic acid synthesis, a phosphate group, a phosphate group protected by a protecting group in nucleic acid synthesis, and an activated phosphate group for solid phase synthesis; and Ar is one of an aromatic hydrocarbon group and a polyaromatic hydrocarbon group.

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献

    [参考文献]: Yves M Dupertuis, Et Al. Unlabelled Iododeoxyuridine Increases The Rate Of Uptake Of [125I]Iododeoxyuridine In Human Xenografted Glioblastomas. Eur J Nucl Med Mol Imaging. 2002 Apr;29(4):499-505.

    合成参考文献


    参考文献:10.1055/s-0028-1083548
    摘要:Mutsumi T, Maruhashi K, Monguchi Y, Sajiki H. Alternative I-D Exchange Reaction on Pyrimidine and Purine Nuclei Mediated by Tributyltin Hydride Using THF-d 8 as a Deuterium Source. Synlett. 2008 Oct 15;2008(18):2811–4. doi: 10.1055/s-0028-1083548.
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