CAS: 3018-12-0; 2,2-Dichloroacetonitrile

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CAS号545-06-2 三氯乙腈 | CAS号77197-84-3 N-benzylidenepe... | CAS号683-72-7 二氯乙酰胺 | CAS号594-65-0 2,2,2-三氯乙酰胺 | CAS号71-30-7 胞嘧啶 | CAS号100-46-9 苄胺 | CAS号921-01-7 D-半胱氨酸 | CAS号66-22-8 尿嘧啶 | CAS号128-09-6 N-氯代丁二酰亚胺 | CAS号372-09-8 氰基乙酸 | CAS号79-36-7 二氯乙酰氯 | CAS号545-06-2 三氯乙腈 | CAS号59782-90-0 2,3-二氯-5-甲基吡啶 | CAS号90044-00-1 2,4-dichloro-4-... | CAS号594-65-0 2,2,2-三氯乙酰胺 | CAS号683-72-7 二氯乙酰胺 | CAS号60523-73-1 溴二氯乙腈 | CAS号128276-98-2 4-氯-2-二氯甲基-5,6-... | CAS号321371-28-2 2-二氯甲基-4,5-二氢噻唑... | CAS号18293-53-3 (三甲硅基)乙腈

二氯乙酰胺置于phosphorus Pentoxide体系中,化学反应生成 二氯乙腈
参考文献:Synthese Des 2-Dichlormethyl-Oxazolin-Carbonsurethylesters-(4) Aus Serinthylester Und Dichloracetimino-Thiothylther
标题:Synthese Des 2-Dichlormethyl-Oxazolin-Carbonsurethylesters-(4) Aus Serinthylester Und Dichloracetimino-Thiothylther
摘要:
DOI:10.1007/bf00899860

专利信息

专利号:US-2023183175-A1
优先权日:2020-03-16
标 题:Method for preparing intermediate for use in synthesis of florfenicol and compounds prepared thereby
发明人：LI WENSEN; ZHANG WENQI
权利人:HEADING NANJING PHARMTECHNOLOGIES CO LTD
摘要:The present invention provides a method for preparing an intermediate of florfenicol, comprising: reacting p-methylthiobenzaldehyde with isocyanoacetate under catalysis of a chiral catalyst. In the reaction, the chiral product is oxidized to form a methylsulfone-substituted product which is subsequently deformylized to obtain the intermediate. In the method of the present invention, the chiral center of the intermediate is directly generated in the first step of reaction, and the yield of the first step reaches 75%-80%, which is significantly higher than the conventional chiral resolution methods (about 40% yield), and the product has high chiral purity. The method of the present invention does not use anhydrous copper sulfate that pollutes the environment, which reduces the environmental pressure. The compound of p-methylthiobenzaldehyde and the compound of isocyanoacetate are used to react to form a chiral intermediate, which has higher material availability and efficiency than linear synthesis methods.

专利号:US-5352832-A
优先权日:1992-12-18
标题 :Asymmetric process for preparing florfenicol, thiamphenicol chloramphenicol and oxazoline intermediates
发明人：WU GUANG-ZHONG; TORMOS WANDA I
权利人:SCHERING CORP
摘要:The present invention comprises a process for the asymmetric synthesis of florfenicol, thiamphenicol or chloramphenicol, from a derivative of trans-cinnamic acid, comprising the steps: n (a) converting the acid to an acid chloride using a chlorinating agent, and reducing the acid chloride to a trans allylic alcohol with a reducing agent; n (b) asymmetrically epoxidizing the allylic alcohol of step (a), by reacting with t-butylhydroperoxide in the presence of a chiral epoxidation catalyst prepared from titanium (IV) isopropoxide and L-diisopropyltartaric acid, to form a chiral epoxide; n (c) regioselectively opening the epoxide of step (b) by sequentially treating with sodium hydride, zinc chloride and dichloroacetonitrile to form an oxazoline; n (d) stereoselective inversion/isomerization of the oxazoline of step (c) by sequentially treating with: (i) a lower alkylsulfonyl chloride and a tertiary amine base; (ii) sulfuric acid and water; (iii) an alkali metal hydroxide; to form an oxazoline; n (e) optionally treating the oxazoline of step (d) with a fluorinating agent, for preparing florfenicol, then hydrolyzing with acid. n In an alternative embodiment, the present invention comprises a process for isomerizing of the S,S-isomer of florfenicol to the R,S-isomer (I) by sequentially treating with: (i) a lower alkylsulfonyl chloride and a tertiary amine base; (ii) sulfuric acid and water; (iii) an alkali metal hydroxide. n The present invention further comprises a process for regioselectively opening an epoxide to form a threo-oxazoline.

专利号:US-4499026-A
优先权日:1982-08-25
标题 :Nucleophilic substitution process
发明人：STAHLY BARBARA C; STAHLY G PATRICK
权利人:ETHYL CORP
摘要:Nitroarylacetonitriles are prepared by reacting a nitroaromatic compound which is devoid of halogen on the aromatic ring carrying a nitro group with an alpha,alpha-disubstituted acetonitrile in an inert solvent and in the presence of a base so that the nitrile undergoes a nucleophilic substitution on an unsubstituted ring carbon of the nitroaromatic compound during which an alpha-substituent functions as a leaving group. Nitrobenzene acetic acids and their nitriles are useful intermediates for the synthesis of pharmaceuticals.

专利号:CN-102827042-A
优先权日:2012-09-17
标 题:Chiral synthesis of Florfenicol

专利号:BR-112016017141-A2
优先权日:2014-04-16
标 题:METHOD FOR THE SYNTHESIS OF FLORFENICOL

专利号:RU-2116299-C1
优先权日:1993-03-12
标题:Method of synthesis of 2-substituted 5-chloroimidazole-4-carbaldehydes and 2-substituted 3,5-dihydroimidazoline-4-one