CAS: 175712-02-4; ((3S,5R)-5-((1H-1,2,4-Triazol-1-yl)Methyl)-5-(2,4-Difluorophenyl)Tetrahydrofuran-3-yl)Methyl 4-Chlorobenzenesulfonate

上下游产品

2,5-脱水-1,3,4-三脱氧-2-C-(2,4-二氟苯基)-4-(羟甲基)-1-(1H-1,2,4-三唑-1-基)-D-苏式-戊糖醇 ((3R,5R)-5-((1H-1,2,4-Triazol-1-yl)Methyl)-5-(2,4-Difluorophenyl)Tetrahydrofuran-3-yl)Methanol 160709-02-4
(4S)-3-{[(5R)-5-(2,4-Difluorophenyl)-5-(Iodomethyl)Tetrahydrofuran-3-Yl]Carbonyl}-4-Phenyl-1,3-Oxazolidin-2-One
((3R,5R)-5-(2,4-Difluorophenyl)-5-(Iodomethyl)Tetrahydrofuran-3-yl)Methanol 182210-71-5

((3R,5R)-5-(2,4-Difluorophenyl)-5-(Iodomethyl)Tetrahydrofuran-3-yl)Methanol置于吡啶,盐酸,Potassium Carbonate,三乙胺体系中,用 二氯甲烷,水,N,N-二甲基甲酰胺,丙酮 用作溶剂,化学反应 30.0H,反应生成(3S-顺式)-4-氯苯磺酸[5-(2,4-二氟苯基)四氢-5-(1H-1,2,4-三唑-1-基甲基)-3-呋喃基]甲基酯
参考文献: A Process For The Manufacture Of Posaconazole[fr] Procédé De Fabrication De Posaconazole
标题: A Process For The Manufacture Of Posaconazole[fr] Procédé De Fabrication De Posaconazole
摘要:本发明公开了一种改进的制备波沙康唑的方法,波沙康唑是一种属于替代四氢呋喃三唑化合物类别的抗真菌药物.本发明进一步描述了制备波沙康唑的关键中间体方程式a和方程式b的方法.该发明还公开了在波沙康唑合成中有用的新型中间体.

专利信息

专利号:WO-2019077627-A1
优先权日:2017-10-16
标题:PROCESS FOR PRODUCING POSACONAZOLE
发明人：NANDEPU Venkateswara Rao; BIJJULA VENKATA KRISHNA REDDY; BATHINA Satyanarayana
权利人:METROCHEM API PVT LTD
摘要:The present invention relates to an improved process for the manufacture of Posaconazole, an antifungal agent belonging to the category of triazole compound substituted tetrahydrofuran. The present invention further relates to the preparation of Formula A and Formula B, key intermediates in the preparation of Posaconazole. The invention also relates to novel intermediates that are useful in the synthesis of Posaconazole.