CAS: 144978-35-8; 1-Boc-D-Pyroglutamic Acid Ethyl Ester

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上下游产品

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D-焦谷氨酸置于4-二甲氨基吡啶,氯化亚砜体系中,用 甲苯 用作溶剂,化学反应 3.0H,反应生成Boc-D-焦谷氨酸乙酯
参考文献: Cyclic Amine Derivatives As Ep4 Receptor Antagonists[fr] Dérivés Aminés Cycliques En Tant Qu'Antagonistes Du Récepteur Ep4
标题: Cyclic Amine Derivatives As Ep4 Receptor Antagonists[fr] Dérivés Aminés Cycliques En Tant Qu'Antagonistes Du Récepteur Ep4
摘要:本发明描述了一组新型的环状胺衍生物化合物,具有ep4受体拮抗活性,特别是用于治疗或减轻前列腺素e介导的疾病的药物化合物.因此,本发明涉及的是新型化合物,它们是pge2受体的ep4亚型的选择性拮抗剂,具有镇痛和抗炎活性,其制备过程,包含它们的药物组合物以及它们作为药物的使用,包括用于治疗或减轻前列腺素e介导的疾病,如急性疼痛,慢性疼痛,骨关节炎,与炎症相关的疾病如关节炎,类风湿性关节炎,癌症,偏头痛和子宫内膜异位症.

专利信息

专利号:CN-115124448-A
优先权日:2022-07-20
标 题:A kind of method for one-pot synthesis of D-pyroglutamic acid derivatives

专利号:US-8835466-B2
优先权日:2006-04-20
标 题 :Synthesis and uses of pyroglutamic acid derivatives
发明人：Ã?LVAREZ BUILLA GÓMEZ JULIO; NOVELLA ROBISCO JOSÉ LUIS; MATÃ?A MARTÃ?N MA PAZ; SERNA PEREDA SONIA
权利人:Ã?LVAREZ BUILLA GÓMEZ JULIO; NOVELLA ROBISCO JOSÉ LUIS; MATÃ?A MARTÃ?N MA PAZ; SERNA PEREDA SONIA; PRODIMED SA
摘要:Novel pyroglutamic acid derivatives (I), wherein R 1 is —OH, —ORa, wherein Ra is alkyl, cycloalkyl, alkenyl, cycloalkenyl, aryl, aralkyl or heterocyclyl; R 2 , R 3 and R 4 are independently H, a nitrogen protecting group which hydrolyzes under acidic conditions or phtalamide; X is a pharmaceutically acceptable anion; and Y is a N-containing group; either in the form of their isolated optically active stereoisomers or in the form of mixtures thereof, are useful compounds for enhancing an immuneresponse in a subject and/or for treating tumors, bacterial, fungal or viral infections, or autoimmune diseases.

专利号:AU-2007242793-B2
优先权日:2006-04-20
标 题 :Synthesis and uses of pyroglutamic acid derivatives

专利号:AU-2007242793-A1
优先权日:2006-04-20
标 题 :Synthesis and uses of pyroglutamic acid derivatives

专利号:US-2007249678-A1
优先权日:2006-04-20
标 题:Synthesis and uses of pyroglutamic acid derivatives

专利号:US-2009163555-A1
优先权日:2006-04-20
标 题:Synthesis and uses of pyroglutamic acid derivatives