CAS: 135689-93-9; 4'-Formyl-[1,1'-Biphenyl]-2-Carbonitrile

相似化合物

205871-49-4 24973-49-7 606-80-4

上下游产品

CAS号114772-54-2 4'-溴甲基-2-氰基联苯 | CAS号1122-91-4 对溴苯甲醛 | CAS号214360-47-1 2-腈基苯硼酸新戊二醇酯 | CAS号209911-63-7 4-(二溴甲基)-[1,1-联... | CAS号3839-22-3 2-氰基苯甲酸 | CAS号131379-17-4 2-氰基苯基溴化锌 | CAS号79-37-8 草酰氯 | CAS号154709-19-0 4-(2-氰基苯基)苄醇 | CAS号2042-37-7 邻溴苯腈 | CAS号87199-17-5 4-甲酰基苯硼酸 | CAS号137863-89-9 缬沙坦烃化物 | CAS号137862-53-4 缬沙坦

📜2-氰基-4'-溴甲基联苯置于乌洛托品,水,Sodium Dodecyl-Sulfate,Lanthanum(Lll) Triflate体系中,化学反应 4.0H,以71%的收率获得2'-氰基-4-甲醛基联苯
参考文献:三氟甲磺酸镧催化改进的sommelet反应
标题:三氟甲磺酸镧催化改进的sommelet反应
摘要:使用三氟甲磺酸镧 (3 Mol%) 作为催化剂,在水中使用十二烷基硫酸钠 (Sds,2 Wt%) 作为增溶剂,实现了用于从苄基卤化物和六亚甲基四胺合成芳醛的改进 Sommelet 反应.在 18 个实施例中的大多数中获得了非常好到极好的收率.
Doi:10.3184/174751914X14175125259964

专利信息

专利号:WO-2005049586-A1
优先权日:2003-11-24
标 题:Process for production of (s) -n-pentanoyl-n-[[2’-(1h-tetrazole-5yl) [1,1’-biphenyl]-4-yl]methyl]-l-valine
发明人：CEPANEC IVICA; LITVIC MLADEN; KORETIC STEFANIJA; BARTOLINCIC ANAMARIJA; DRUSKOVIC VINKA; SPOREC ANITA
权利人:BELUPO LIJEKOVI KOZMETIKA D D; CEPANEC IVICA; LITVIC MLADEN; KORETIC STEFANIJA; BARTOLINCIC ANAMARIJA; DRUSKOVIC VINKA; SPOREC ANITA
摘要:The patent relates to a new process of synthesis of an antihypertensive agent, N-pentanoyl-N-[[2'-(1H-tetrazole-5-yl)[1,1'-biphenyl]-4-yl]methyl]-L-valine (1), also known under the generic name of valsartan, by selective reaction of N-pentanoyl-N-[[2'-(1H-tetrazole-5-yl) [1,1'-biphenyl]-4-yl]methyl]-L-valine methyl-ester (14) with metallic or quaternary ammonium trialkylsilanolates by SN2 reaction. The compound 14 was produced in four reaction steps starting from 2N-trityl-5-(4'-methylbiphenyl-2-yl)tetrazole (17) and L-valine methyl-ester (11). Free-radical bromination of the compound 17 with N-bromosuccinimide produced 2N-trityl-5-(4'-bromomethylbiphenyl-2-yl)tetrazole (7), which in the reaction with L-valine methyl-ester (11) results in N-[[2'-(2N-trityl-tetrazole-5-yl)[1,1'-biphenyl]-4­yl]methyl]-L-valine methyl-ester hydrobromide (15). Acylation of the compound 15 with pentanoyl chloride in the presence of trialkylamine bases results in N-pentanoyl-N-[[2'-(2N­trityl-tetrazole-5-yl)[1,1'-biphenyl] -4-yl]methyl]-L-valine methyl-ester (16). Removal of trityl protecting group by strong acids produces the key intermediary, compound 14.

专利号:EP-1831186-B1
优先权日:2004-11-30
标题:A process for the synthesis of valsartan
发明人：ZUPANCIC SILVO; PECAVAR ANICA; ZUPET ROK
权利人:KRKA D D NOVO MESTO
摘要:This invention relates to an improved process for preparing a valsartan, or a pharmaceutically acceptable salt thereof, or pharmaceutical preparation containing either entity wherein a compound of formula (II) nor a salt thereof, is reacted with valine or an ester or a salt thereof in a solvent selected from the group consisting of methylene chloride, chloroform, butyl chloride, isopropyl acetate and tert -butyl methyl ether to form a compound of formula (IV) nwhich is then acylated to form a compound of formula (VI) nwherein R is hydrogen, alkyl, alkenyl or benzyl; which is then deprotected to give valsartan, and may be converted to a pharmaceutically acceptable salt and/or a pharmaceutical formulation. The invention also covers intermediates of formula (IV) and (VI) wherein R=H.

专利号:WO-2006058701-A1
优先权日:2004-11-30
标题:A process for the synthesis of valsartan

专利号:EP-1831186-A1
优先权日:2004-11-30
标题:A process for the synthesis of valsartan

专利号:EP-1661891-A1
优先权日:2004-11-30
标 题 :A process for the synthesis of valsartan

专利号:CN-115197096-A
优先权日:2021-04-13
标 题 :Synthesis method of valsartan intermediate