CAS: 133095-91-7; Magnesium,1,2,3-Trimethoxybenzene-5-Ide,Bromide

上下游产品

CAS号2675-79-8 5-溴-1,2,3-三甲氧基苯 | CAS号208347-68-6 1,2,3-trimethox... | CAS号182163-96-8 3,4,5-三甲氧基苯硼酸

📜1-溴-3,4,5-三甲氧基苯 反应生成3,4,5-三甲氧基苯基溴化镁
参考文献:J. Med. Chem. 2010,53,6337-6354
标题:J. Med. Chem. 2010,53,6337-6354

专利信息

专利号:US-6403814-B1
优先权日:1998-10-16
标 题 :Method for synthesizing diaryl-substituted heterocyclic compounds, including tetrahydrofurans
发明人：RAO ALLA VENKATA RAMA; CHORGHADE MUKUND S; ISLAM AMIN UL; RAO VEMURI VENKATA KIRAN; PRASAD ANEGONDI SREENIVASA; RAO BATCHU VENKATESWARA; REDDY RANGA; REDDY LALATA KRISHNAKANTH; SHAILAJA KOTAKONDA; GURJAR MUKUND KESHAO; MHASKAR SUNIL VYANKATESH
权利人:MILLENNIUM PHARM INC
摘要:A method is provided for synthesizing diaryl-substituted heterocyclic compounds, particularly 2,5-diaryl-substituted tetrahydrofurans and tetrahydrothiophenes. Methods for synthesizing starting materials and intermediates are provided as well. An important application of the invention is in the synthesis of CMI-392, (±)trans-2-[5-N'-methyl-N'-hydroxyureidyl-methyl)3-methoxy-4-p-chlorophenylthioethoxyphenyl]-5-(3,4,5-trimethoxyphenyl)-tetrahydrofuran, a highly effective agent in treating inflammatory and immune disorders. The invention also encompasses novel compounds useful as starting materials and intermediates in the synthetic processes disclosed.

专利号:US-2002128491-A1
优先权日:1999-10-15
标题 :Method for synthesizing diaryl-substituted heterocyclic compounds, including tetrahydrofurans
发明人：RAO ALLA VENKATA RAMA; CHORGHADE MUKUND S; ISLAM AMIN UL; RAO VEMURI VENKATA KIRAN; PRASAD ANEGONDI SREENIVASA; RAO BATCHU VENKATESWARA; REDDY RANGA; REDDY LALATA KRISHNAKANTH; SHAILAJA KOTAKONDA; GURJAR MUKUND KESHAO; MHASKAR SUNIL VYANKATESH
摘要:A method is provided for synthesizing diaryl-substituted heterocyclic compounds, particularly 2,5-diaryl-substituted tetrahydrofurans and tetrahydrothiophenes. Methods for synthesizing starting materials and intermediates are provided as well. An important application of the invention is in the synthesis of CMI-392, (±) trans-2-[5-(N′-methyl-N′-hydroxyureidyl-methyl)-3-methoxy-4-p-chlorophenylthioethoxyphenyl]-5-(3,4,5-trimethoxyphenyl)-tetrahydrofuran, a highly effective agent in treating inflammatory and immune disorders. The invention also encompasses novel compounds useful as starting materials and intermediates in the synthetic processes disclosed.