CAS: 1069-72-3; 2-Bromo-N,N-Diethylethylamine Hydrobromide

相似化合物

2862-39-7 636-70-4 554-68-7

上下游产品

CAS号100-37-8 二乙氨基乙醇 | CAS号589-32-2 四乙基胱胺-13C4 | CAS号104-79-0 N,N-二乙基-N'-甲基乙二胺 | CAS号125906-52-7 N,N-diethyl-2-q... | CAS号109-89-7 二乙胺 | CAS号84434-83-3 N-[(4-chlorophe... | CAS号5392-81-4 2-溴-N,N-二乙基乙胺氢溴酸 | CAS号5427-35-0 N-(4-chlorophen...

📜二乙氨基乙醇置于三溴化磷体系中,用 甲苯 用作溶剂,化学反应生成2-二乙氨基-1-溴乙烷氢溴酸盐
参考文献:一种盐酸胺碘酮的制备方法
标题:一种盐酸胺碘酮的制备方法
摘要:本发明公开了一种盐酸胺碘酮的制备方法,具体步骤为:首先以2‑丁基苯并呋喃为起始原料,与对甲氧基苯甲酰氯发生傅克酰基化反应和去甲基反应,得到2‑丁基‑3‑(4‑羟基苯甲酰基)苯并呋喃,然后2‑丁基‑3‑(4‑羟基苯甲酰基)苯并呋喃与碘发生碘代反应,得到2‑丁基‑3‑(3,5‑二碘‑4‑羟基苯甲酰基)苯并呋喃,最后2‑丁基‑3‑(3,5‑二碘‑4‑羟基苯甲酰基)苯并呋喃与2‑二乙氨基溴乙烷氢溴酸盐发生缩合反应,调节ph浓缩析晶重结晶,即得盐酸胺碘酮.本发明缩合反应采用2‑二乙氨基溴乙烷氢溴酸盐,规避了起始原料不易购买的问题,同时提高了反应效率,成品的质量也有所提高,并且制备工艺简单,操作方便,生产周期更短,更适合于工业化生产.

专利信息

专利号:US-2024409495-A1
优先权日:2021-10-20
标 题 :Process for the preparation of 2,7-dihydroxy-9-fluorenone useful for the synthesis of tilorone and its salts
发明人：JAISANKAR PARASURAMAN; DEB INDUBHUSAN; BHATTACHARJEE PINAKI
权利人:COUNCIL SCIENT IND RES
摘要:Methods involving preparation of building blocks of 2,7-dihydroxy-9-fluorenone toward the synthesis of tilorone dihydrochloride salt and other salts (bromide, iodide, fluoride, citrate, oxalate, maleate, phosphate, tartrate, triflate, trifluoroacetate, tetrafluoroborate) of tilorone, and an efficient, safe, cost effective method for the preparation of 2,7-bis-[2-(diethylamino)ethoxy]-fluorenone-9 and its various salts are developed. The methods involve oxygenation of fluorene, nitration of fluorenone, followed by reduction and diazotization toward the formation of 2,7-dihydroxy-9-fluorenone, which is the key intermediate for the formation of 2,7-bis-[2-(diethylamino)ethoxy]-9-fluorenone-dihydrochloride (Tilorone dihydrochloride) and other tilorone salts. The synthesis method has relatively simple operation, mild reaction conditions, high yield, and simple process with yields of 80-97%. Subsequent product purification of this method uses filtration and crystallization methods, avoiding the existing methods of column chromatography. Therefore, the research of its synthetic method being with a wide range of applications from the drug development and material synthesis point of view.

专利号:WO-2023067624-A1
优先权日:2021-10-20
标 题 :A process for the preparation of 2,7-dihydroxy-9-fluorenone useful for the synthesis of tilorone and its salts

专利号:CN-118175999-A
优先权日:2021-10-20
标题 :Process for the preparation of 2, 7-dihydroxy-9-fluorenone useful for the synthesis of telulone and its salts

专利号:CA-3235754-A1
优先权日:2021-10-20
标 题 :A process for the preparation of 2,7-dihydroxy-9-fluorenone useful for the synthesis of tilorone and its salts

专利号:EP-0617288-B1
优先权日:1993-03-19
标题 :Long emission wavelength chemiluminescent compounds and their use in test assays
发明人：LAW SAY-JONG; JIANG QINGPING; FISCHER WALTER; UNGER JOHN T; KRODEL ELIZABETH K
权利人:NOVARTIS AG; BAYER AG
摘要:An assay method incorporating at least two different chemiluminescent compounds for detection and/or quantitation of at least two substances in a test sample is described. The synthesis of chemiluminescent reagents or conjugates for use in such methods as well as kits incorporating such reagents are also disclosed. The assays have particular application in the field of clinical diagnostics.

专利号:US-7189749-B2
优先权日:1999-06-25
标 题 :Substituted phenoxyacetic acids
发明人：VAN ZANDT MICHAEL C
权利人:INST FOR PHARM DISCOVERY INC
摘要:Disclosed are substituted phenoxyacetic acids useful in the treatment of chronic complications arising from diabetes mellitus. Also disclosed are pharmaceutical compositions containing the compounds, alone or in combination with other therapeutic agents, and methods of treatment employing the compounds and pharmaceutical compositions, as well as methods for their synthesis.