CAS: 1007-99-4; 2-Amino-4-Chloro-6-Hydroxy-5-Nitropyrimidine

相似化合物

3137-56-2 4214-85-1 51471-45-5

上下游产品

CAS号1194-21-4 2-氨基-4-氯-6-羟基嘧啶 | CAS号114113-85-8 2-amino-6-(4,4-... | CAS号80466-56-4 2-氨基-4,6-二羟基-5-硝基嘧啶 | CAS号51471-45-5 N-(6-氯-5-硝基-4-氧...

📜2-氨基-6-氯-4-羟基嘧啶置于硫酸,Potassium Nitrate体系中,化学反应 1.5H,以72%的收率获得2-氨基-4-氯-5-硝基-6-羟基嘧啶
参考文献:二氨基亚甲基氨基羰基二硝基甲烷,是在硝化2-氨基-6-氯-4(3 H)-嘧啶酮的过程中形成2-氨基-6-氯-5-硝基-4(3 H)-嘧啶酮的过程中形成的
标题:二氨基亚甲基氨基羰基二硝基甲烷,是在硝化2-氨基-6-氯-4(3 H)-嘧啶酮的过程中形成2-氨基-6-氯-5-硝基-4(3 H)-嘧啶酮的过程中形成的
摘要:显示出硝化2-氨基-6-氯-4(3 H)-嘧啶酮的困难,得到广泛使用的杂环前体2-氨基-6-氯-5-硝基-4(3 H)-嘧啶酮由于形成了不寻常的开链宝石-二硝基化合物,被鉴定为二氨基亚甲基氨基羰基二硝基甲烷.后者也通过2-氨基-4,6(3 H,5 H)-嘧啶二酮的硝化反应形成.它在二甲基亚砜或氢氧化钾水溶液中损失二氧化碳而分解,得到胍和二硝基甲烷.
Doi:10.1016/s0040-4039(00)02360-1

专利信息

专利号:US-5350851-A
优先权日:1992-03-16
标题 :Intermediates and a process for synthesis of tetrahydropteridine C6-stereoisomers, including (6S)-tetrahydrofolate and N5-formyl-(6S)-tetrahydrofolate
发明人：BAILEY STEVEN W; AYLING JUNE E
权利人:UNIV SOUTH ALABAMA
摘要:Intermediates and a process for the synthesis of 6-monosubstituted tetrahydropteridine C6-stereoisomers, including (6S)-tetrahydrofolic acid. The intermediates are shown in their two enantiomeric forms as follows: ##STR1## wherein R 1 and R 2 are the same or different and represent hydrogen, methyl, hydroxy, amino, alkyl or dialkylamino, alkoxy, benzyloxy, or benzylthio; R 3 represents an alkene, alkyne, cycloalkyl, benzyl, alkyl (substituted with hydroxy, acetoxy, benzyloxy, alkoxy, alkylthio, amino, carboxy, oxo, or phosphate), a protected aldehyde, or ##STR2## wherein n=1 or 2, R 4 is hydrogen, formyl, methyl, or propargyl, and ZZ represents an amino acid or amino acid polymer.

专利号:US-3959278-A
优先权日:1970-07-27
标 题 :Method of synthesis of pteridines
发明人：WOOD HAMISH CHRISTOPHER SWAN; STUART ALEXANDER; CURRAN ADRIAN CHARLES WARD; AL-HASSAN SAIEBA
权利人:BURROUGHS WELLCOME CO
摘要:A pharmaceutical formulation of a compound of formula (II') ##SPC1## n wherein Y is a lower alkyl group, in association with a pharmaceutically acceptable carrier, as an antibacterial product, and methods involving the preparation and reductive cyclization of a compound of formula (IV) ##SPC2## n wherein X is a lower alkyl group or a hydroxymethyl group.

专利号:US-5401844-A
优先权日:1983-04-11
标 题 :Regulation of enzymes which utilize tetrahydrobiopterin or tetrahydrofolate cofactors with 6,6-disubstituted-tetrahydropteridines
发明人：AYLING JUNE E; BAILEY STEVEN W
权利人:UNIV SOUTH ALABAMA
摘要:6-[2'-Amino-2',2'-disubstituted-ethylamino]-pyrimidines of the structure: ##STR1## in which X=H, NH 2 or NO 2 , which are novel intermediates in the synthesis of quinoid 6,6-disubstituted-dihydro- and 6,6-disubstituted-tetrahydro-pteridines, are claimed.

专利号:US-11912734-B2
优先权日:2020-01-28
标题:Solid-phase synthesis of oligonucleotides containing N6-(2-deoxy-alpha,beta-derythropentofuranosyl)-2,6-diamino-4-hydroxy-5-formamidopyrimidine (Fapyâ‹…dG)
发明人：GREENBERG MARC M; YANG HAOZHE
权利人:UNIV JOHNS HOPKINS
摘要:A strategy using reverse phosphoramidites for synthesizing oligonucleotides containing Fapy·dG is disclosed.

专利号:US-2011124634-A1
优先权日:2008-05-13
标 题:Bioactive compounds for treatment of cancer and neurodegenerative diseases
发明人：SUN CONNIE L; LI XIAOYUAN
权利人:PONIARD PHARMACEUTICALS INC
摘要:The invention provides bioactive compounds for the treatment of various malconditions such as cancer and neurodegenerative diseases including Alzheimer's disease. The chemical compounds as disclosed herein are found to show bioactivity in bioassays related to these conditions. Pharmaceutical compositions, combinations and methods of synthesis are provided, as are methods of using the compound, compositions and combinations in the treatment of the diseases.

专利号:ES-2397104-T3
优先权日:2002-12-11
标 题 :Procedure and intermediate products for the synthesis of entecavir