CAS: 98-61-3; 4-Iodobenzenesulfonyl Chloride

该化合物是一种有机化合物,其特征是:存在一个全氟氯化锡组和一个附于苯环的碘原子,它看起来像是白色到浅黄色晶体固体,以其反应性为著称,特别是由于它具有反应会发生核循环替代反应的全氟氯化烷功能组,该化合物在二氯甲烷和氯仿等有机溶剂中溶解,但一般在水中溶解,经常被用作有机合成的试剂,特别是在制作磺酰胺和其他磺酰衍生物时;此外,碘的存在会提高它在各种组合反应中的效用,并成为合成途径中的潜在电极;然而,由于它具有腐蚀性,而且可能对健康造成危害,包括对皮肤和呼吸系统产生刺激,因此,必须谨慎地处理它;在与该化合物合作时,适当的安全防范措施,包括使用个人防护设备,至关重要.

结构式图片

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

CAS号5122-99-6 4-碘苯硼酸 | CAS号13035-63-7 4-碘苯磺酸钾 | CAS号591-50-4 碘苯 | CAS号121-57-3 对氨基苯磺酸 | CAS号35371-03-0 4-碘茴香硫醚 | CAS号87424-99-5 ethyl-(4-iodo-p... | CAS号67-66-3 氯仿 | CAS号7782-50-5 氯气 | CAS号7790-94-5 氯磺酸 | CAS号22184-85-6 4-碘-N,N-二甲基苯磺胺 | CAS号2751-27-1 4-碘苯磺酰肼 | CAS号131134-90-2 1-methyl-4-nitr... | CAS号154377-75-0 tert-butyl N-(4... | CAS号326885-27-2 4-碘-N-(四氢-2-呋喃甲... | CAS号13035-63-7 4-碘苯磺酸钾 | CAS号170159-17-8 S-[4-(2-trimeth... | CAS号1565-17-9 4-乙酰基苯磺酰胺 | CAS号169590-42-5 塞来昔布 | CAS号2143-88-6 1-(4-甲基苯基)-4-硝基苯

合成工艺路线路线简述

    对氨基苯磺酸置于iodo-131,Potassium Iodide体系中,化学反应生成 4-碘苯磺酰氯
    参考文献:一种测定同位素衍生物形式的有机化合物的方法;通过载体技术估算氨基酸.
    标题:一种测定同位素衍生物形式的有机化合物的方法;通过载体技术估算氨基酸.
    摘要:
    DOI:10.1021/ja01169A064

    专利信息


    专利号:US-7429670-B2
    优先权日:2003-08-27
    标题 :Synthesis of derivatives of ginkgolide C
    发明人:NAKANISHI KOJI; JARACZ STANISLAV; STROMGAARD KRISTIAN
    权利人:UNIV COLUMBIA
    摘要:The subject invention provides ginkgolide C derivatives compounds having the structure: n n n n n n n n n n wherein R is H or -A-Ar,n where A is an alkyl group; and Ar is an aryl group, which may contain heteroatoms and may be unsubstituted or substituted by one to five substituents each selected from the group consisting of hydrogen, alkoxy, —CH 2 CO 2 R 4 , and —CH 2 CONR 5 R 6 ;n where R 4 is an alkyl group; and R 5 and R 6 are each, independently, hydrogen or a branched or unbranched alkyl group; n n n wherein R 1 is H or —COR 7 ,n where R 7 is alkyl, aryl or amino; n n wherein R 2 is present or absent, and when present is H, —COR 8 or —CO—Z—R 8 ;n where R 8 is alkyl, aryl or amino; and Z is oxygen; n n wherein R 3 is present or absent, and when present is —COR 9 ;n where R 9 is alkyl or aryl; n n wherein only one of R 2 or R 3 is present in the compound; n wherein only two of R, R 1 , R 2 and R 3 are H; and n wherein each of a and b designates a single covalent bond which is present or absent,n where bond a is present when R 3 is absent and bond b is present when R 2 is absent;n nor an optically pure enantiomer of the compound. Additionally, the subject invention provides methods of inhibiting the activity of a glycine receptor using these compounds.

    专利号:WO-2019013789-A1
    优先权日:2017-07-12
    标 题 :ANTIMICROBIAL COMPOUNDS
    发明人:REDDY HARIPRASADA R KANNA; SEBAHAR PAUL R; SERRANO CATHERINE M; LOOPER RYAN E
    权利人:CURZA GLOBAL LLC; THE UNIV OF UTAH RESEARCH FOUNDATION
    摘要:The invention relates to compounds of formula I or their pharmaceutically acceptable salts. The compounds of formula I are antimicrobial agents which inhibit, for example, Mycobacterium tuberculosis (Mtb) H37Ra. The compounds of formula I also have anti-tuberculous activity, exhibit limited cytotoxicity and inhibit protein synthesis. The invention also relates to methods of making compounds of formula I, as well as methods of using compounds of formula I for the treatment of bacterial infections, particularly tuberculosis.

    专利号:US-2009221019-A1
    优先权日:2005-06-22
    标 题:Core-Modified Terpene Trilactones From Ginkgo Biloba Extract and Biological Evaluation Thereof
    发明人:NAKANISHI KOJI; DZYUBA SERGEI; ISHII HIDEKI
    权利人:NAKANISHI KOJI; DZYUBA SERGEI; ISHII HIDEKI
    摘要:Lactone-rings of ginkgolides are converted into the corresponding tetrahydrofuran moieties via DIBAL-H reduction followed by deoxygenation of the formed lactols with Et 3 SiH/BF 3 Et 2 O producing a series of lactol-free ginkgolides. The present invention also relates to synthesis of hydroxyl-free, or hydroxyl-free and lactone-free, ginkgolides and bilobalides.

    专利号:US-2005119336-A1
    优先权日:2003-08-27
    标 题:Synthesis of derivatives of ginkgolide C

    专利号:CN-101365674-A
    优先权日:2005-07-21
    标题:Modulators of interleukin-1 and tumor necrosis factor alpha, synthesis of the modulators and methods of using the modulators

    专利号:WO-2005021496-A2
    优先权日:2003-08-27
    标 题 :Synthesis of derivatives of ginkgolide c
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    ✅ COA系统入驻 | 共享模式

    主要参考文献

    参考标题:Cobalt(II)-Catalyzed Isocyanide Insertion Reaction With Sulfonyl Azides In Alcohols: Synthesis Of Sulfonyl Isoureas
    作者:Tian Jiang,Zheng-Yang Gu,Ling Yin,Shun-Yi Wang,Shun-Jun Ji |发布日期:2017.8.4
    摘要:A Co(II)-Catalyzed Isocyanide Insertion Reaction With Sulfonyl Azides In Alcohols To Form Sulfonyl Isoureas Via Nitrene Intermediate Has Been Developed. This Protocol Provides A New, Environmentally Friendly, And Simple Strategy For The Synthesis Of Sulfonyl Isourea Derivatives By Employing A Range Of Substrates Under Mild Conditions.

    合成参考文献


    参考文献:10.1007/978-3-642-52704-3_7
    摘要:Shcherbakova, I., Science of Synthesis, (2007) 31, 813.
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