CAS: 936-70-9; 1-(2-Hydroxyethyl)Pyrimidine-2,4(1H,3H)-Dione

该化合物是一种化学化合物,其特点是其火水环结构,这是一个由六人组成的芳香环,含有位于1号阵地和3号阵地的两个氮原子;该化合物的特点是1号阵地的氢氧乙基组和2号和4号阵地的两个碳基组,有助于其丁酮的性质;由于存在氢氧基化合物,它通常是一种白色至白的晶状固体,在水和酒精等极溶剂中溶解.该化合物展示了生物活动,经常因其在制药中的潜在用途而进行研究,特别是在开发抗病毒和抗癌剂方面,其活性可归因于碳基组的存在,这些组可以参与各种化学反应,包括核糖激素添加物.

结构式图片

相似化合物

4113-97-7 1343949-10-9 5236-60-2

物理性质

MSDS等安全信息

上下游产品

CAS号96-49-1 碳酸乙烯酯 | CAS号66-22-8 尿嘧啶 | CAS号15765-13-6 1-[2-(乙酰基氧基)乙基]... | CAS号66191-47-7 1-(2-bromoethyl...

合成工艺路线路线简述

  • 15765-13-6 = 936-70-9
    反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Methanol,Water
    标题:An Improved Synthesis Of 1-(2-Hydroxyethyl)Uracil
    作者:Garnaik,Baijayantimala
    参考文献:Organic Preparations And Procedures International 日期:1995 卷标:27(6) 页码:657-9]

    96-49-1 + 66-22-8 = 936-70-9
    反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Dimethylformamide; 1.5 H,Reflux
    标题:Reactivity Models Of 1-N-Vinyluracil And Synthesis Of A New Class Of Potential Antiviral Agents By The Use Of 1,3-Dipolar Cycloaddition Reactions
    作者:Colacino,E.; De Luca,G.; Liguori,A.; Napoli,A.; Siciliano,C.; Et Al
    参考文献:Nucleosides 日期:2003 卷标:22(5-8) 页码:743-745]

    96-49-1 + 66-22-8 = 936-70-9
    反应条件:1.1 Reagents: Sodium Hydroxide; 12 H,Rt
    标题:Preparation Of Base-Modified Adriamycin Prodrug-Nucleoside Analog Co-Assembled Nanoparticles
    参考文献:China]

    = 936-70-9 [标题:Reaction Conditions
    标题:Synthesis Of Dihydroisoxazole Nucleoside And Nucleotide Analogs
    作者:Gi,Hung-Jang; Xiang,Yuejun; Schinazi,Raymond F.; Zhao,Kang
    参考文献:Journal Of Organic Chemistry 日期:1997 卷标:62(1) 页码:88-92]

    = 936-70-9 [标题:Reaction Conditions
    标题:Synthesis And Properties Of A Cyclic Derivative Of Uracil
    作者:Akashi,Mitsuru; Futagawa,Hidekazu; Inaki,Yoshiaki; Kondo,Koichi; Takemoto,Kiichi
    参考文献:Nucleic Acids Research 日期:1977 卷标:3 页码:7-10]

    = 936-70-9 [标题:Reaction Conditions
    标题:Nonglycosidic Analogs Of Nucleotides. 3. Hydroxyalkyl Derivatives Of Nucleic Bases
    作者:Mikhailov,S. N.; Kolobushkina,L. I.; Kritsyn,A. M.; Padyukova,N. Sh.; Florent'Ev,V. L.
    参考文献:Izvestiya Akademii Nauk Sssr 日期:1974 卷标:(11) 页码:2582-8]

    = 936-70-9 [标题:Reaction Conditions
    标题:Reaction Of Uracil And Adenine With Ethylene Carbonate
    作者:Ustyuzhanin,G. E.; Kolomeitseva,V. V.; Tikhomirova-Sidorova,N. S.
    参考文献:Zhurnal Obshchei Khimii 日期:1973 卷标:43(9) 页码:2093-4]

    2554978-32-2 = 936-70-9
    反应条件:1.1 Reagents: Ammonia Solvents: Methanol; 4 D,Rt
    标题:Novel Ring Transformation Of Uracils To 2-Oxazolidinones
    作者:Kitamura,Yoshiaki; Nagaya,Yuki; Ohshima,Yuto; Kato,Daiki; Ohguchi,Asuki; Et Al
    参考文献:Heterocycles 日期:2020 卷标:100(4) 页码:622-631]

    96-49-1 + 66-22-8 = 936-70-9
    反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Dimethylformamide; Overnight,140 °C
    标题:Preparation Of Fluorescent Structural Analogs Of Amine Bases And Nucleosides And Their Incorporation Into Dna
    参考文献:World Intellectual Property Organization]

    939-54-8 + 66-22-8 = 936-70-9
    反应条件:1.1 Reagents: Chlorotrimethylsilane,Hexamethyldisilazane; Reflux1.2 Reflux -> 165 °C; 2.5 H,160 - 165 °C; 165 °C -> 25 °C1.3 Reagents: Sodium Pyrosulfite Solvents: Tetrahydrofuran,Water; 25 °C1.4 Reagents: Potassium Hydroxide Solvents: Ethanol; 30 Min,Reflux1.5 Reagents: Carbon Dioxide Solvents: Water; Reflux
    标题:Method Of Producing 1-(ω-Hydroxyalkyl)Uracils
    参考文献:Russian Federation]

    66191-47-7 = 936-70-9
    反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Water; 48 H,50 °C
    标题:Synthesis Of Uracil Nucleotide Analogs With A Modified,Acyclic Ribose Moiety As P2Y2 Receptor Antagonists
    作者:Sauer,Roland; El-Tayeb,Ali; Kaulich,Marko; Mueller,Christa E.
    参考文献:Bioorganic & Medicinal Chemistry 日期:2009 卷标:17(14) 页码:5071-5079]

    96-49-1 + 66-22-8 = 936-70-9
    反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Dimethylformamide; 10 Min,Heated1.2 Overnight,90 °C
    标题:Synthesis And Polymerization Of 1-(2-Diallylaminoethyl)Pyrimidines
    作者:Elaridi,Jomana; Ezzeddine,Alaa; Abramian,Lara; Koubeissi,Ali; Vladimirov,Nikolay; Et Al
    参考文献:Designed Monomers And Polymers 日期:2018 卷标:21(1) 页码:64-74]

    96-49-1 + 66-22-8 = 936-70-9
    反应条件:1.1 Reagents: Sodium Hydroxide Solvents: 1,4-Dioxane
    标题:Two Simple Protocols For The Preparation Of Diallylaminoethyl-Substituted Nucleic Bases: A Comparison
    作者:Shatila,Rania S.; Bouhadir,Kamal H.
    参考文献:Tetrahedron Letters 日期:2006 卷标:47(11) 页码:1767-1770]

    103022-66-8 = 936-70-9
    反应条件:1.1 Solvents: Dimethylformamide
    标题:Synthesis Of Poly-L-Glutamates Containing 5-Substituted Uracil Moieties
    作者:Mochizuki,Eiko; Inaki,Yoshiaki; Takemoto,Kiichi
    参考文献:Nucleic Acids Symposium Series 日期:1985 卷标:16 页码:121-4]

    = 936-70-9 [标题:Reaction Conditions
    标题:Hydroxyethylation Of Uracil,Adenine,And Cytosine By Ethylene Carbonate
    作者:Ustyuzhanin,G. E.; Kolomeitseva,V. V.; Tikhomirova-Sidorova,N. S.
    参考文献:Khimiya Geterotsiklicheskikh Soedinenii 日期:1978 卷标:(5) 页码:684-9]

    = 936-70-9 [标题:Reaction Conditions
    标题:β-Hydroxyalkylation With Ethylene Carbonates In The Presence Of Tetraalkylammonium Halides
    参考文献:Japan]

    = 936-70-9 [标题:Reaction Conditions
    标题:N-Vinyl Derivatives Of Substituted Pyrimidines And Purines
    作者:Pitha,Josef; Ts'O,Paul O. P.
    参考文献:Journal Of Organic Chemistry 日期:1968 卷标:33(4) 页码:1341-4]

    96-49-1 + 66-22-8 = 936-70-9 + 700-03-8
    反应条件:1.1 Solvents: Dimethylformamide
    标题:Reaction Between Uracil And Ethylene Carbonate
    作者:Tuppy,H.; Kuechler,E.
    参考文献:Monatshefte Fuer Chemie 日期:1964 卷标:95(6) 页码:1698-701]

    96-49-1 + 66-22-8 = 936-70-9 + 711-66-0
    反应条件:1.1 Solvents: Dimethylformamide
    标题:Nucleic Acid Components And Their Analogs. Xvii. Reaction Of Uracil And Of Its Aza Analogs With Ethylene Carbonate
    作者:Prystas,M.; Gut,J.
    参考文献:Colleciion Czech. Chem. Commun. 日期:1962 卷标:27 页码:1054-6]

    96-49-1 + 66-22-8 = 936-70-9 + 711-66-0
    反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Dimethylformamide; 140 °C; 1 H,155 °C; 2 H,80 °C
    标题:Preparation And Self-Organizing Assembly Of Porphyrin Molecules For Use In The Conversion Of Light To Chemical Or Electrical Energy
    参考文献:Germany
📜1-[2-(乙酰基氧基)乙基]-2,4(1H,3H)-嘧啶二酮置于盐酸,甲醇体系中,化学反应 1.0H,以73%的收率获得产物1-(2-羟乙基)嘧啶-2,4(1H,3H)-酮
参考文献:Garnaik,Baijayantimala,Organic Preparations And Procedures International,1995,Vol. 27,# 6,P. 657-659
标题:Garnaik,Baijayantimala,Organic Preparations And Procedures International,1995,Vol. 27,# 6,P. 657-659

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参考文献:10.1007/s10593-020-02729-x
摘要:Novakov IА, Brunilina LL, Kirillov IА, Nawrozkij MB, Robinovich MD, Titova ES, Sheikin DS, Ruchko EА, Pavlova AV, Kotlyarova AА, Tolstikova TG. The synthesis of new acyclic analogs of 3-phenacyluridine and comparative evaluation of their in vivo biological activity. Chemistry of Heterocyclic Compounds. 2020 Jun;56(6):769–75. doi: 10.1007/s10593-020-02729-x.
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