CAS: 91-22-5; Quinoline

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CAS号635-46-1 1,2,3,4-四氢喹啉 | CAS号14465-74-8 N-(2-丙炔基)苯胺 | CAS号148-24-3 8-羟基喹啉 | CAS号50-00-0 甲醛 | CAS号3867-18-3 2-乙烯基苯胺 | CAS号93-10-7 喹哪啶酸 | CAS号98-95-3 硝基苯 | CAS号56-81-5 甘油 | CAS号4363-93-3 4-喹啉甲醛 | CAS号574-39-0 9-乙酰基咔唑 | CAS号76890-09-0 2-(2,5-dimethyl... | CAS号3075-84-1 2,2',5,5'-四甲基联苯 | CAS号76890-20-5 2-(2,5-dimethyl... | CAS号4549-74-0 3-甲基-1,3-戊二烯(顺反... | CAS号4412-96-8 3-甲基-2-呋喃羧酸 | CAS号612-59-9 3-氯喹啉 | CAS号1011-47-8 1-(喹啉-2-基)乙酮 | CAS号60814-30-4 1-(喹啉-4-基)乙-1-酮 | CAS号21718-94-5 1-(2-acetylquin...

Dimethyl-Sulfamic Acid Quinolin-8-Yl Ester置于potassium Phosphate,[1,3-Bis(2,4,6-Trimethylphenyl)-4,5-Dimethyl]Imidazolium Chloride,C46H39Clnip2,异丙醇体系中,用 甲苯 作为反应溶剂,化学反应 15.15H,以90%的收率获得产物喹啉
参考文献:以醇为温和还原剂的镍催化芳基氨基磺酸盐加氢脱氧
标题:以醇为温和还原剂的镍催化芳基氨基磺酸盐加氢脱氧
摘要:使用醇作为温和的还原剂开发了镍催化的氨基磺酸芳基酯的加氢脱氧反应.在该反应体系中可以容忍多种官能团和杂环,从而以高产率得到所需的产物.此外,还高效地实现了克级工艺和逐步电影替代.
DOI:10.1055/a-1548-8362

专利信息

专利号:WO-2013138200-A1
优先权日:2012-03-13
标 题 :Green chemistry synthesis of the malaria drug amodiaquine and analogs thereof
发明人：FORTUNAK JOSEPH MARIAN; KULKARNI AMOL ANANT; KING CHRISTOPHER
权利人:UNIV HOWARD
摘要:Methods are provided for a green chemistry one-pot synthesis of amodiaquine and amodiaquine analogs. The methods have a lower environmental impact, lower investment cost, reduced amounts of byproducts and impurities, and a shorter synthesis time, compared to current conventional synthesis methods. The methods reduce the total number of steps in the synthesis from four to five down to two, thereby simplifying production; and allow a reduced number of solvents and reagents to be used in production, thereby reducing the waste generated in the synthesis. The methods can reduce the waste to about 3-5 kilograms of waste generated per kilogram of product produced; and surprisingly improve the overall yield from 60-65% to greater than 90% as compared to the current conventional synthesis methods for amodiaquine and its analogs.

专利号:US-2004018598-A1
优先权日:2000-05-30
标题 :Bio-intermediates for use in the chemical synthesis of polyketides
发明人：SANTI DANIEL; ASHLEY GARY; MYLES DAVID C
摘要:The present invention relates to compounds made by a subset of modules from one or more polyketide synthase (“PKSâ€?) genes that are used as starting material in the chemical synthesis of novel molecules, particularly naturally occurring polyketides or derivatives thereof. The biologically derived intermediates (“bio-intermediatesâ€?) generally represent particularly difficult compounds to synthesize using traditional chemical approaches due to one or more stereocenters. In one aspect of the invention, an intermediate in the synthesis of epothilone is provided that feeds into the synthetic protocol of Danishefsky and co-workers. In another aspect of the invention, intermediates in the synthesis of discodermolide are provided that feed into the synthetic protocol of Smith and co-workers. By taking advantage of the inherent stereochemical specificity of biological processes, the syntheses of key intermediates and thus the overall syntheses of compounds like epothilone and discodermolide are greaty simplified.

专利号:US-2008086013-A1
优先权日:2006-06-15
标 题:Carbometallation of alkynes and improved synthesis of uniquinones
发明人：LIPSHUTZ BRUCE H
权利人:UNIV CALIFORNIA
摘要:Methods for the carbometallation of alkynes are presented. Those are useful for the synthesis of CoQ 10 and other ubiquinones as well as for the synthesis of ubiquinol analogs.

专利号:US-9126995-B2
优先权日:2011-11-08
标题:Method for catalytic asymmetric synthesis of optically active isoxazoline compound and optically active isoxazoline compound
发明人：TOYAMA KEN-ICHI; MORIYAMA YUJI; MATOBA KAZUTAKA; YAOSAKA MANABU; IKEDA EITATSU
权利人:NISSAN CHEMICAL IND LTD
摘要:There is provided a method for catalytic asymmetric synthesis of optically active isoxazoline compound and an optically active isoxazoline compound. A method for catalytic asymmetric synthesis of optically active isoxazoline compound of a formula (6) including reacting an α,β-unsaturated carbonyl compound of a formula (1) and a hydroxylamine in a solvent in the presence of a base by adding a chiral phase transfer catalyst. An optically active isoxazoline compound of a formula (13) that can be synthesized by the method.

专利号:US-7692016-B2
优先权日:2005-11-25
标 题 :Process for the synthesis of quinoline derivatives
发明人：MADUGULA SREE RAMA MURTY; THALLAPELLY SWAMY; BANDARUPALLY JYOTHIRMAI; YADAV JHILLU SINGH
权利人:COUNCIL SCIENT IND RES
摘要:The present invention provides an improved process for the synthesis of quinoline derivatives. More particularly the present invention provides an improved and economical process for the synthesis of quinoline derivatives by the reaction of aniline/substituted anilines using two different catalysts, ferric chloride and zinc chloride in a one-pot set up reaction.

专利号:US-5569762-A
优先权日:1994-01-14
标题:Asymmetric synthesis of intermediates for retroviral protease inhibitor compounds
发明人：WISSNER ALLAN; TROVA MICHAEL P
权利人:AMERICAN CYANAMID CO
摘要:The disclosure describes an improved process for producing optically active compounds of Formula II or III, which compounds are useful as intermediates for preparing compounds active as inhibitors of retroviral protease enzymes: ##STR1## wherein R 1 , R 50 and Z are described in the specification. The improved process includes either synthesis of diastereomeric iodolactones which are separated prior to conversion to compounds of Formula II or III or synthesis of an epoxide which is converted directly to compounds of Formula II and III.