CAS: 90721-27-0; Benzofuran-5-Carboxylic Acid

该化合物是一种有机化合物,其特征是其结合的苯并呋喃和箱状酸功能组,一般是白色的,白色以外的固体,在有机溶剂中可溶解,尽管其在水中的溶解性有限;该化合物的特征是苯并呋喃环,它有助于其芳香特性,以及一个含有酸性特征的箱状酸组;这一物质在各个领域都具有意义,包括有机合成和药用化学,因为它在制药中的潜在生物活动和用途;由于存在箱状酸组,它可以进一步发挥功能,在化学反应中成为多功能的中间体;此外,其结构特征可能影响其反应和与生物系统的相互作用,需要进一步调查其特性和潜在用途;在处理和储存方面,应参考安全数据,如任何化学物质一样.

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相似化合物

108763-47-9 31823-05-9 79002-39-4

物理性质

MSDS等安全信息

欧盟法规

C&L通报

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CAS号108763-47-9 苯并呋喃-5-甲酸甲酯 | CAS号588702-80-1 2,3-二氢-5-苯并呋喃羧酸甲酯 | CAS号90843-31-5 5-乙酰基-2,3-二氢苯并[b]呋喃 | CAS号76429-73-7 2,3-二氢苯并呋喃-5-甲酸 | CAS号53596-60-4 methyl 3-allyl-... | CAS号108763-47-9 苯并呋喃-5-甲酸甲酯 | CAS号56540-70-6 1-苯并呋喃-5-羰酰氯

合成工艺路线路线简述

  • 合成目标产物 Benzofuran-5-Carboxylic Acid 主要起始原料 Methyl Benzofuran-5-Carboxylate
  • 31823-05-9 = 90721-27-0
    反应条件:1.1 Reagents: Oxygen Catalysts: Potassium Chloride,1-Butanaminium,N,N,N-Tributyl-,Ferratehexa-μ3-Hydroxyhexa-μ-Oxododecaoxohexamo... Solvents: Water; 24 H,1 Atm,70 °C
    标题:Selective Iron-Catalyzed Aerobic Oxidation Of Alcohols In Water To Carboxylic Acids Mediated By Additives
    作者:Yu,Han; Ren,Jingjing; Xie,Ya; Su,Xiaofang; Wang,Aiping; Et Al
    参考文献:Green Chemistry 日期:2022 卷标:24(17) 页码:6511-6516]

    18441-43-5 = 90721-27-0
    反应条件:1.1 Reagents: Potassium Persulfate,Oxygen Catalysts: Molybdate(3-),Chromatehexa-μ3-Hydroxyhexa-μ-Oxododecaoxohexa-,Ammonium (1:3) Solvents: Water; 24 H,50 °C
    标题:An Efficient Chromium(Iii)-Catalyzed Aerobic Oxidation Of Methylarenes In Water For The Green Preparation Of Corresponding Acids
    作者:Jiang,Feng; Liu,Shanshan; Zhao,Wenshu; Yu,Han; Yan,Likai; Et Al
    参考文献:Dalton Transactions 日期:2021 卷标:50(36) 页码:12413-12418]

    23145-07-5 = 90721-27-0
    反应条件:1.1 Reagents: Tetrabutylammonium Tetrafluoroborate,1,5,7-Triazabicyclo[4.4.0]Dec-5-Ene Catalysts: Naphthalene Solvents: Dimethylformamide; 6 H,1 Atm,Rt1.2 Reagents: Hydrochloric Acid Solvents: Water; Acidified
    标题:Metal-Free Electrochemical Carboxylation Of Organic Halides In The Presence Of Catalytic Amounts Of An Organomediator
    作者:Wang,Yanwei; Zhao,Zhiwei; Pan,Deng; Wang,Siyi; Jia,Kangping; Et Al
    参考文献:Angewandte Chemie 日期:2022 卷标:61(41)]

    108763-47-9 = 90721-27-0
    反应条件:1.1 Reagents: Lithium Hydroxide Solvents: Methanol,Tetrahydrofuran,Water; 18 H,20 °C1.2 Reagents: Hydrochloric Acid Solvents: Water; Ph 2
    标题:Structure-Activity Relationships For Analogs Of The Tuberculosis Drug Bedaquiline With The Naphthalene Unit Replaced By Bicyclic Heterocycles
    作者:Sutherland,Hamish S.; Tong,Amy S. T.; Choi,Peter J.; Conole,Daniel; Blaser,Adrian; Et Al
    参考文献:Bioorganic & Medicinal Chemistry 日期:2018 卷标:26(8) 页码:1797-1809]

    4111-54-0 = 90721-27-0
    反应条件:1.1 Catalysts: Carbon Dioxide
    标题:β-Deprotonation By Lithium Diisopropylamide. Vinyl Carbanions From Oxygen Heterocycles In The Synthesis Of Carboxylic Acids In The Benzofuran,Flavone,And Coumarin Series And In The Regiospecific Acylation Of 2,6-Dimethylchromone
    作者:Costa,Ana M. B. S. R. C. S.; Dean,Francis M.; Jones,Michael A.; Smith,Dennis A.; Varma,Rajender S.
    参考文献:Journal Of The Chemical Society 日期:1980 卷标:(24) 页码:1224-6
📜5-乙酰基-2,3-二氢苯并[b]呋喃置于sodium Hydroxide,Sodium Hypochlorite,硫酸,2,3-二氯-5,6-二氰基-1,4-苯醌体系中,用 1,4-二氧六环,甲醇 作为反应溶剂,化学反应 53.0H,反应生成 1-苯并呋喃-5-甲酸
参考文献:Discovery Of N-[(3R)-1-Azabicyclo[2.2.2]oct-3-Yl]Furo[2,3-C]Pyridine-5-Carboxamide,An Agonist Of The α7 Nicotinic Acetylcholine Receptor,For The Potential Treatment Of Cognitive Deficits In Schizophrenia: Synthesis And Structure−activity Relationship
标题:Discovery Of N-[(3R)-1-Azabicyclo[2.2.2]oct-3-Yl]Furo[2,3-C]Pyridine-5-Carboxamide,An Agonist Of The α7 Nicotinic Acetylcholine Receptor,For The Potential Treatment Of Cognitive Deficits In Schizophrenia: Synthesis And Structure−activity Relationship
摘要:N-[(3R)-1-Azabicyclo[2.2.2] oct-3-Yl] Furo[2,3-C]Pyridine-5-Carboxamide (14,Pha-543,613),A Novel Agonist Of The Alpha 7 Neuronal Nicotinic Acetylcholine Receptor (Alpha 7 Nachr),Has Been Identified As A Potential Treatment Of Cognitive Deficits In Schizophrenia. Compound 14 Is A Potent And Selective Alpha 7 Nachr Agonist With An Excellent In Vitro Profile. The Compound Is Characterized By Rapid Brain Penetration And High Oral Bioavailability In Rat And Demonstrates In Vivo Efficacy In Auditory Sensory Gating And,In An In Vivo Model To Assess Cognitive Performance,Novel Object Recognition.
DOI:10.1021/jm0602413

海关参考信息

专利信息


专利号:EP-1836163-B1
优先权日:2004-12-23
标题 :Pyrrolidine derivatives for the treatment of a disease depending on the activity of renin
发明人：BREITENSTEIN WERNER; COTTENS SYLVAIN; EHRHARDT CLAUS; JACOBY EDGAR; LORTHIOIS EDWIGE LILIANE JEANNE; MAIBAUM JUERGEN KLAUS; OSTERMANN NILS; SELLNER HOLGER; SIMIC OLIVER
权利人:NOVARTIS AG
摘要:Novel 3-mono-, 3,4-di- and 3,4,4,-tri-substituted pyrrolidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on inappropriate activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on inappropriate activity of renin; the use of a compound of that class in the treatment of a disease that depends on inappropriate activity of renin; pharmaceutical formulations comprising a said substituted pyrrolidine compound, and/or a method of treatment comprising administering a said substituted pyrrolidine compound, a method for the manufacture of said substituted pyrrolidine compounds, and novel intermediates and partial steps for their synthesis are described. The substituted pyrrolidine compounds are especially of the formula I wherein the substituents are as described in the specification.

专利号:US-4609739-A
优先权日:1984-11-06
标 题:Synthetic routes to benzofurans and benzothiophenes and intermediates therefor
发明人：GAMMILL RONALD B
权利人:UPJOHN CO
摘要:The present invention provides novel compositions of matter and processes for their preparation. More particularly, the present invention consists of novel chemical intermediates and associated processes for the preparation of khellin and other furochromone analogues, which have demonstrated antiatherosclerotic activity. These novel intermediates and processes can also be used for the preparation of benzofurans and benzothiophenes which inhibit the synthesis of leukotriene and/or lipoxygenase.

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合成参考文献


参考文献:10.5281/zenodo.5794106
摘要:The LOTUS Initiative for Open Natural Products Research: frozen dataset union wikidata (with metadata) | DOI:10.5281/zenodo.5794106
参考文献:10.1016/s0031-9422(00)89935-5
摘要:Bu'Lock JD, Kaye B, Hudson AT. New benzofurans from stereum subpileatum, their biosynthesis, and related processes of aromatic aminoacid metabolism in a basidiomycete. Phytochemistry. 1971 May;10(5):1037–46. doi: 10.1016/s0031-9422(00)89935-5.
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