CAS: 79-03-8; Propionyl Chloride

上下游产品

CAS号96-22-0 3-戊酮 | CAS号98-88-4 苯甲酰氯 | CAS号51430-68-3 3,4-dichlorohex... | CAS号16844-98-7 丙酸三甲基硅酯 | CAS号4353-77-9 三甲基甲硅烷 | CAS号7719-12-2 三氯化磷 | CAS号56-23-5 四氯化碳 | CAS号7782-50-5 氯气 | CAS号108223-66-1 1-(5-ethylthiop... | CAS号105-91-9 (Z)-3,7-二甲基-2,6... | CAS号1118-32-7 Propanamide,N-(... | CAS号1113-75-3 N,N-di(propan-2... | CAS号106921-60-2 2,2-二甲基-3-氧代戊醛 | CAS号109532-92-5 2-phenyl-5-prop... | CAS号1073-26-3 2-丙酰基吡咯 | CAS号10601-63-5 Propanamide,N-(... | CAS号111038-94-9 1-(3,4-dihydro-... | CAS号1114-59-6 N,N-Dipropylpro...

丙酸置于氯化亚砜体系中,用 二氯甲烷 作为反应溶剂,化学反应 1.0H,反应生成 丙酰氯
参考文献:Schofneri Schofneri提取物和化合物的抗伤害作用.
标题:Schofneri Schofneri提取物和化合物的抗伤害作用.
摘要:民族药理学相关性hofmeisteria Schaffneri(菊科)是一种药用植物,在墨西哥城最重要的市场中被广泛商业化,用于治疗胃肠道不适和皮肤病.研究目的本研究的主要目标是在动物模型中建立沙夫(hofmeisteria Schaffneri)的几种制剂和化合物的潜在急性毒性和抗伤害感受活性.材料与方法分别通过注入,浸渍和加氢蒸馏来制备沙夫霍夫甲的水和有机提取物以及香精油.急性毒性的研究通过lorke方法完成.使用扭体试验和热板试验评估抗伤害感受作用.通过标准植物化学方法分离天然化合物.另外,通过化学合成制备了一些百里酚酯.通过测量其在37摄氏度下对猪肝硬脂酸酶和小鼠血浆的水解敏感性,定性分析了天然酯和合成酯的稳定性.结果每种测试制剂的ld(50)均高于5000 Mg / Kg,表明它们没有短时间暴露后对小鼠有毒.另一方面,当在热板模型中进行测试时,提取物显示出明显的镇痛作用.作为抗伤
DOI:10.1016/j.Jep.2010.07.009

专利信息

专利号:US-2015284338-A1
优先权日:2012-11-21
标 题:Industrial process for the synthesis of pyrimidinyl-piperazine derivatives
发明人：SZAVICSKÓ KRISZTINA; Domány György; Czibula László; Bartáné Szalai Gizella; Dobay László; WERKNÉ PAP ÉVA
权利人:RICHTER GEDEON NYRT
摘要:Our invention relates to trans-(4-{4-[2-(4-amino-cyclohexyl)-ethyl]-piperazin-1-yl}-5,6-dichloro-pyrimidin-2-yl)-methylamine dihydrochloride monohydrate, the process for the synthesis of this compound, the new (4,5-dichloro-6-piperazin-1-yl-pyirimidin-2-yl)-methylamine monohydrochlorid used as starting material in this synthesis, as well as the industrial process for the synthesis of trans-N-(4- {2-[4-(5,6-dichloro-2-methyl-amino-pyirimidin-4-yl-)piperazin-1-yl]-ethly}cyclohexyl-propionamide starting from trans-(4-{4-[2-(4-amino-cyclohexyl)-ethyl]-piperazin-1-yl}-5,6-dichloro-pyrimidin-2-yl)-methylamine dihydrochloride monohydrate.

专利号:US-5861532-A
优先权日:1997-03-04
标 题:Solid-phase synthesis of N-alkyl amides
发明人：BROWN EDWARD G; NUSS JOHN M
权利人:CHIRON CORP
摘要:Methods for solid phase synthesis of N-alkyl amides comprise reductive amination of carbonyl compounds using a reducing agent and an amine-containing linker bound to a solid support. The methods afford high yields of linker-bound, monoalkylated amines, and subsequent coupling with acid derivatives provide derivatized N-substituted amides in excellent yields after cleavage from the solid-phase. Compositions useful in solid phase synthesis are also described.

专利号:WO-2024084491-A1
优先权日:2022-10-21
标题:Process for synthesis of res metirom and its intermediates thereof
发明人：MEHTA NILESH VIPINCHANDRA
权利人:MEHTA NILESH VIPINCHANDRA
摘要:The present invention discloses a process for synthesis of Res metirom and its intermediates thereof. More particularly, the invention discloses process for synthesis of a key intermediate, 6-(4-amino, 2,6-dichlorophenoxy)4- isopropylpyridazin-3(2H)-one, of Res metirom via novel intermediate compounds of formula A. Wherein, R is selected from methyl, ethyl and propyl.

专利号:US-7692019-B2
优先权日:2000-12-04
标 题:Methods for the stereoselective synthesis of substituted piperidines
发明人：AQUILA BRIAN M; BANNISTER THOMAS D; CUNY GREGORY D; HAUSKE JAMES R; HEFFERNAN MICHELE L R; HOEMANN MICHAEL Z; KESSLER DONALD W; SHAO LIMING; WU XINHE; XIE ROGER L
权利人:SEPRACOR INC
摘要:One aspect of the present invention relates to methods of synthesizing substituted piperidines. A second aspect of the present invention relates to stereoselective methods of synthesizing substituted piperidines. The methods of the present invention will find use in the synthesis of compounds useful for treatment of numerous ailments, conditions and diseases that afflict mammals, including but not limited to addiction and pain. An additional aspect of the present invention relates to the synthesis of combinatorial libraries of the substituted piperidines using the methods of the present invention. An additional aspect of the present invention relates to enantiomerically substituted pyrrolidines, piperidines, and azepines.

专利号:US-2023159450-A1
优先权日:2020-05-08
标 题 :Dimers for use in synthesis of peptidomimetics
发明人：AL-ABED YOUSEF; ALTITI AHMAD
权利人:FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
摘要:Dimers for use in synthesis of peptidomimetics are described. Uses of dimers as synthons in synthesis of azapeptides and other peptidomimetics, azapeptides and other peptidomimetics synthesized from the dimers and uses of azapeptides and other peptidomimetics are also described.

专利号:US-3906004-A
优先权日:1968-12-09
标题 :Stereoselective synthesis of intermediate for preparation of meso-nordihydroguaiaretic acid
发明人：PERRY CLARK WILLIAM
权利人:HOFFMANN LA ROCHE
摘要:This invention is directed to the stereoselective synthesis of the food additive meso-nordihydroguaiaretic acid from a protected ortho dihydroxy benzene and intermediates in this synthesis.