CAS: 729-99-7; 4-Amino-N-(4,5-Dimethyloxazol-2-yl)Benzenesulfonamide

该化合物是属于硫酸类药物的磺酰胺抗生素,以其抗菌特性而著称,主要用于治疗细菌感染,特别是尿道感染;硫化物的化学结构具有磺酰胺组的化学结构,这是其抗微生物活动必不可少的,其特点是它能够与亚氨基苯甲酸(PABA)竞争,从而抑制细菌叶酸合成;这一机制干扰核酸的生产,并最终抑制细菌生长;硫化物经常与三甲基磷酸结合使用,以提高其对抗广泛细菌的功效;该化合物一般是口服,在胃肠道中吸收良好;其致癌性包括中度蛋白质结合和相对较长的半衰期,可以方便地按期服用.然而,与其他磺酰胺一样,硫氧化物可产生副作用,包括过敏反应和血解紊乱,在治疗期间必须仔细监测.

结构式图片

欧盟法规

ECHA物质ECHA物质C&L通报REACH预注册

上下游产品

(4,5-dimethyl-oxazol-2-yl)-bis-(4-nitro-benzenesulfonyl)-amine N-acetyl-sulfanilyl)-(4,5-dimethyl-oxazol-2-yl)-aminebis-(N-acetyl-sulfanilyl)-(4,5-dimethyl-oxazol-2-yl)-amine 2-amino-4,5-dimethyloxazole 4-Nitrobenzenesulfonyl chloride4-{[1-(5-Chloro-2-hydroxy-3-nitro-phenyl)-1-phenyl-meth-(E)-ylidene]-amino}-N-(4,5-dimethyl-oxazol-2-yl)-benzenesulfonamide N-(4,5-Dimethyl-oxazol-2-yl)-4-{[1-(2-hydroxy-phenyl)-meth-(E)-ylidene]-amino}-benzenesulfonamide Benzoic acid 4-chloro-2-{[(E)-4-(4,5-dimethyl-oxazol-2-ylsulfamoyl)-phenylimino]-phenyl-methyl}-6-nitro-phenyl ester 4-[N'-(1-Acetyl-2-oxo-propylidene)-hydrazino]-N-(4,5-dimethyl-oxazol-2-yl)-benzenesulfonamide

合成工艺路线路线简述

    📜4,5-二甲基噁唑-2-胺置于盐酸,铁粉体系中,化学反应生成 磺胺二甲唑
    参考文献:De1003737
    标题:De1003737

    专利信息


    专利号:US-8975340-B2
    优先权日:2010-12-15
    标题 :Synthesis of sequestration resins for water treatment in light water reactors
    发明人:YENGOYAN LEON; FRATTINI PAUL L; WELLS DANIEL MORGAN
    权利人:YENGOYAN LEON; FRATTINI PAUL L; WELLS DANIEL MORGAN; ELECTRIC POWER RES INST
    摘要:An organic synthesis of materials to achieve removal of low molecular weight ionic species, such as transition metal ions including cobalt, iron, nickel, and zinc, from aqueous solutions. The synthesis includes the steps of providing a cation exchange resin, functionalizing the cation exchange resin using a chloride intermediate to form a sulfonyl chloride resin, and reacting a multi-amine based ligand with the sulfonyl chloride resin to form a sequestration resin. The synthesis further includes the steps of cooling the sequestration resin, and washing and drying the sequestration resin.

    专利号:US-8461357-B2
    优先权日:2008-09-19
    标题 :Expeditious synthesis of gibberellin A5 and esters thereof
    发明人:FAIRWEATHER KELLY A; MANDER LEWIS N; PHARIS RICHARD P
    权利人:FAIRWEATHER KELLY A; MANDER LEWIS N; PHARIS R P; UTI LIMITED PARTNERSHIP
    摘要:An expeditious synthesis of gibberellin A 5 (GA 5 ) esters is presented, from which GA 5 may be prepared. The synthesis offers an inexpensive route of few steps to these compounds, starting from gibberellin A 3 (GA 3 ) esters in the presence of a metal hydride.

    专利号:US-5886104-A
    优先权日:1993-06-18
    标题 :Grafted cross-linked polyolefin substrates for peptide synthesis and assays
    发明人:PEDERSEN WALTHER BATSBERG; ALMDAL KRISTOFFER; WINTHER LARS; BERG ROLF HENRIK
    权利人:FORSKNIINGSCENTER RISO
    摘要:A solid support for the solid-phase synthesis of peptides or proteins in high yield and in high purity, suited both to the synthesis of a single peptide or protein and to the parallel and substantially simultaneous synthesis of a plurality thereof, is based on a cross-linked polyolefin, especially polyethylene, substrate, the cross-linking having been obtained by irradiation with high energy electrons or γ radiation or treatment with organic peroxide such as benzoyl peroxide, to which substrate are grafted polymer chains such as polystyrene chains which are functionalized with a chemical functionality facilitating the formation of an anchoring linkage between the polymer moiety and another chemical species. The solid support is also suited for use in solid-phase biosystems, notably bioassays, such as immunoassays, DNA hybridization assays or PCR amplification. The grafted chains may bear substituents which are such that the polymer-grafted cross-linked polyolefin substrate is swellable by water or aqueous media, in other words, hydrophilic, which makes the solid support particularly well suited for assays of the ELISA type.

    专利号:US-7951905-B2
    优先权日:2006-09-18
    标 题 :Synthesis of carbohydrate-templated amino acids and methods of using same
    发明人:SCHWEIZER FRANK; ZHANG KAIDONG; OWENS NEIL; ZHANEL GEORGE
    权利人:UNIV MANITOBA
    摘要:The present invention generally relates to tetrahydropyranyl-derivatized amino acids, their syntheses and their incorporation into peptides and peptidomimetics. The tetrahydropyran moiety constrains the side chain of an amino acid, thereby providing a molecule that may act as a sugar- or amino acid-mimetic as well as a scaffold for combinatorial synthesis.

    专利号:US-7256197-B2
    优先权日:2001-10-12
    标 题 :Methods for synthesis of diarylmethanes
    发明人:ROSOWSKY ANDRE; CHEN HAN
    权利人:DANA FARBER CANCER INST INC
    摘要:The present invention relates to dihydrofolate reductase inhibitors having an aromatic group and a heteroaromatic group linked by a methylene group; methods of preparation of dihydrofolate reductase inhibitors that include metal mediated cross coupling of an aromatic halide or heteroaromatic halide with an organozinc reagent; and methods of treatment and pharmaceutical compositions that utilize or comprise one or more of such dihydrofolate reductase inhibitors.

    专利号:US-5728366-A
    优先权日:1994-04-29
    标 题:Two powder synthesis of hydrotalcite and hydrotalcite-like compounds with monovalent organic anions
    发明人:MARTIN EDWARD S; STINSON JOHN M; CEDRO III VITO; HORN JR WILLIAM E
    权利人:ALUMINUM CO OF AMERICA
    摘要:There is provided a method for making monovalent organic anion-intercalated hydrotalcite-like materials by first reacting a magnesium-containing powder and a transition alumina powder in a carboxylic acid-free, aqueous suspension to form a meixnerite intermediate. This intermediate is then contacted with a monovalent organic anion to form a hydrotalcite-like material. The latter is then separated from the suspension. Representative materials include a stearate-, acetate- or benzoate-intercalated hydrotalcite-like material.

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    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献


    1: Oyedeji AO, Msagati TAM, Williams AB, Benson NU. Determination of antibiotic residues in frozen poultry by a solid-phase dispersion method using liquid chromatography-triple quadrupole mass spectrometry. Toxicol Rep. 2019 Sep 17;6:951-956. doi: 10.1016/j.toxrep.2019.09.005.
    2: Zhou D, Thiele-Bruhn S, Arenz-Leufen MG, Jacques D, Lichtner P, Engelhardt I. Impact of manure-related DOM on sulfonamide transport in arable soils. J Contam Hydrol. 2016 Sep;192:118-128. doi: 10.1016/j.jconhyd.2016.07.005. Epub 2016 Jul 16.
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    合成参考文献


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    摘要:S72 | NTUPHTW | Pharmaceutically Active Substances from National Taiwan University | DOI:10.5281/zenodo.3955664
    参考文献:10.1002/bies.10114
    摘要:Bermingham A, Derrick JP. The folic acid biosynthesis pathway in bacteria: evaluation of potential for antibacterial drug discovery. Bioessays. 2002 Jul;24(7):637–48. doi: 10.1002/bies.10114.
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