CAS: 5413-80-9; 1H-Pyrazolo[3,4-D]Pyrimidine-4,6-Diamine
该化合物是一种异环化合物,其内有4和6个位置的聚氨基丙酰胺核心,有氨基替代成分,在4和6个位置,这种结构在药用化学和药物研究中具有很大的多功能性,特别是作为活性酶抑制剂和核核核素类比的脚架.其硬性双环框架加强了目标互动中的结合性和选择性,而二胺功能允许进一步衍生,从而能够开发生物活性分子.该化合物的稳定性和合成可及性使其成为药物发现中有价值的中间体,特别是抗癌和抗病毒应用.其定义明确的化学特性促进了研发的再生结果.
相似化合物
2380-63-4 287177-82-6 5417-78-7物理性质
MSDS等安全信息
上下游产品
CAS号16617-46-2 3-氨基-4-氰基吡唑 | CAS号593-85-1 碳酸胍 | CAS号398117-44-7 1H-Pyrazolo[3,4... | CAS号637338-77-3 1H-Pyrazolo[3,4...合成工艺路线路线简述
📜Alkaline Earth Salt Of/the/ Methylsulfuric Acid置于乙醇,氨体系中,化学反应生成 1H-吡唑并[3,4-D]嘧啶-4,6-二胺
参考文献:Robins,Journal Of The American Chemical Society,1957,Vol. 79,P. 6407,6412
标题:Robins,Journal Of The American Chemical Society,1957,Vol. 79,P. 6407,6412
专利信息
专利号:US-2024294532-A1
优先权日:2021-07-12
标题 :Synthesis of chiral substituted pyrazolopyrimidine compounds
发明人：TOMAS LOÃ?C; HARRIS CRAIG STEVEN
权利人:GALDERMA HOLDING S A
摘要:The present invention relates to processes and intermediates for the preparation of compounds useful as inhibitors of mechanistic target of rapamycin (mTOR).
专利号:EP-4370517-A1
优先权日:2021-07-12
标题 :Synthesis of chiral substituted pyrazolopyrimidine compounds
专利号:WO-2023285926-A1
优先权日:2021-07-12
标题 :Synthesis of chiral substituted pyrazolopyrimidine compounds
专利号:US-11020399-B2
优先权日:2011-05-04
标 题:Intermediates useful in the synthesis of compounds as modulators of protein kinases
专利号:RU-2035452-C1
优先权日:1985-12-20
标 题 :Method of n-phenylpyrazole synthesis
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
参考标题:Recognition Of Artificial Nucleobases ByE. ColiPurine Nucleoside Phosphorylase Versus Its Ser90Ala Mutant In The Synthesis Of Base-Modified Nucleosides作者:Ilja V. Fateev,Maria I. Kharitonova,Konstantin V. Antonov,Irina D. Konstantinova,Vasily N. Stepanenko,Roman S. Esipov,Frank Seela,Kartik W. Temburnikar,Katherine L. Seley-Radtke,Vladimir A. Stepchenko,Yuri A. Sokolov,Anatoly I. Miroshnikov,Igor A. Mikhailopulo |发布日期:2015.9.14
摘要:Mechanism Of Recognition By The Wild‐type (Wt) E. Coli Purine Nucleoside Phosphorylase (Pnp) Versus Its Ser90Ala Mutant. The Results Were Analyzed From Viewpoint Of The Role Of The Ser90 Residue And The Structural Features Of The Bases. It Was Found That The Ser90 Residue Of The Pnp 1) Plays An Important Role In The Binding And Activation Of 8‐aza‐7‐deazapurines In The Synthesis Of Their Nucleosides, 2) Participates
合成参考文献
摘要:B. M. Lynch, R. K. Robins, and C. C. Cheng. J. Chem. Soc. 1958, 2973.
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