CAS: 52683-81-5; (S)-4,4-Difluoropyrrolidine-2-Carboxylic Acid

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CAS号203866-15-3 N-B°C-4,4-二氟-L-脯氨酸 | CAS号102195-80-2 N-B°C-4-氧-L-脯氨酸甲酯 | CAS号203866-17-5 N-B°C-4,4-二氟-L-脯氨酸甲酯 | CAS号40216-83-9 L-羟脯氨酸甲酯盐酸盐 | CAS号74844-91-0 N-B°C-反式-4-羟基-L... | CAS号148429-57-6 (S)-3,3-bis(tri...

📜N-Boc-顺式-4-羟基-L-脯氨酸甲酯置于盐酸,二乙胺基三氟化硫,水,戴斯-马丁氧化剂,Lithium Hydroxide体系中,用 四氢呋喃,二氯甲烷,乙酸乙酯 作为反应溶剂,化学反应 38.0H,反应生成 4,4-二氟脯氨酸
参考文献: Spiro Ring Compound As Hepatitis C Virus (Hcv) Inhibitor And Uses Thereof Field Of The Invention[fr] Composé De Type Noyau Spiro Utilisable En Tant Qu'Inhibiteur Du Virus De L'Hépatite C (Vhc) Et Ses Utilisations,Domaine De L'Invention
标题: Spiro Ring Compound As Hepatitis C Virus (Hcv) Inhibitor And Uses Thereof Field Of The Invention[fr] Composé De Type Noyau Spiro Utilisable En Tant Qu'Inhibiteur Du Virus De L'Hépatite C (Vhc) Et Ses Utilisations,Domaine De L'Invention

专利信息

专利号:US-9206222-B2
优先权日:2009-06-29
标题:Solid phase peptide synthesis of peptide alcohols
发明人：CAUSSIL-AMBLARD MURIEL; MARTINEZ JEAN; TAILHADES JULIEN
权利人:CAUSSIL-AMBLARD MURIEL; MARTINEZ JEAN; TAILHADES JULIEN; CENTRE NAT RECH SCIENT
摘要:The present invention relates to the synthesis of depsipeptides on solid phase support. Said depsipeptides are then implicated in a solution phase O—N acyl shift enabling to obtain the corresponding peptide alcohols.

专利号:US-2024400608-A1
优先权日:2021-09-03
标题:Synthesis of bicycle toxin conjugates, and intermediates thereof
发明人：WITTY DAVID; LIMB DARREN; MIN BYOUNG JOON; HE LIWEN; SANDERS WILLIAM J; NNANABU ERNEST OBINNA
权利人:BRICYCLETX LTD
摘要:The present invention relates to Bicycle toxin conjugates, methods for preparation, and methods of use for treating cancer.

专利号:US-8546533-B2
优先权日:2008-08-29
标 题:Pipecolic linker and its use for chemistry on solid support
发明人：MARTINEZ JEAN; ZAJDEL PAWEL; PAWLOWSKI MACIEJ; SUBRA GILLES
权利人:MARTINEZ JEAN; ZAJDEL PAWEL; PAWLOWSKI MACIEJ; SUBRA GILLES; CENTRE NAT RECH SCIENT; UNIV MONTPELLIER 1; UNIV JAGELLONE; UNIV MONTPELLIER II
摘要:The present invention relates to a pipecolic linker and its use as a solid-phase linker in organic synthesis. Said pipecolic solid-phase linker may be used for coupling functional groups chosen between primary amines, secondary amines, aromatic amines, alcohols, phenols and thiols. In particular, said pipecolic solid-phase linker may be used for peptide or pseudopeptide synthesis, such as the reverse N to C peptide synthesis or the retro-inverso peptide synthesis, or for the synthesis of small organic molecules.

专利号:WO-2023031623-A2
优先权日:2021-09-03
标 题 :Synthesis of bicycle toxin conjugates, and intermediates thereof

专利号:WO-2011000848-A1
优先权日:2009-06-29
标题 :Solid phase peptide synthesis of peptide alcohols

专利号:US-11759496-B2
优先权日:2016-05-10
标题:Compounds and pharmaceutical use thereof in the treatment of cancer
发明人：SUSIN SANTOS A; KAROYAN PHILIPPE; MERLE-BERAL HÉLÈNE
权利人:KAROYAN PHILIPPE
摘要:The present invention relates to a compound or a pharmaceutical salt thereof comprising a hexapeptide sequence of formula (I), its method of synthesis and its use in anticancer therapy. The invention also relates to a pharmaceutical composition for use in the treatment of cancer comprising at least one soluble peptide according to the invention or at least one acid nucleic according to the invention or at least one expression vector according to the invention, or at least one host cell according to the invention and a pharmaceutically acceptable carrier.