CAS: 46193-76-4; Ethyl 4H-Thieno[3,2-B]Pyrrole-5-Carboxylate

相似化合物

39793-31-2 82782-85-2 238749-50-3

上下游产品

4H-噻唑[3,2-B]吡咯-5-甲酸 4H-Thieno[3,2-B]Pyrrole-5-Carboxylic Acid 39793-31-2

📜Ethyl 2-Nitro-3-(Thiophen-2-yl)Acrylate置于[(1,10-Phenanthroline)Pd](Tetrafluoroborate)2,一氧化碳,三乙胺体系中,用 乙腈 作为反应溶剂,150.0 °C,500.01 Kpa 条件下,反应 3.0H,反应生成 4H-噻吩[3,2-B]吡咯-5-羧酸乙酯
参考文献:钯催化的硝基烯烃分子内环化:噻吩并吡咯的合成
标题:钯催化的硝基烯烃分子内环化:噻吩并吡咯的合成
摘要:
DOI:10.1002/ejoc.201901022

专利信息

专利号:WO-2008022467-A1
优先权日:2006-08-25
标 题 :2-substituted azain doles and 2 substituted thienopyrroles, their precursors and novel processes for the preparation thereof
发明人：LAUTENS MARK; YUEN JOSEPHINE; FANG YUANQING
权利人:LAUTENS MARK; YUEN JOSEPHINE; FANG YUANQING
摘要:The present invention relates generally to processes for the chemical synthesis of azaindole and thienopyrrole compounds, in particular azaindole and thienopyrrole compounds that are substituted at the 2-position of the azaindole or thienopyrrole ring, and optionally at additional locations of the azaindole or thienopyrrole ring such as the 1- and/or 3-position, compounds prepared by such processes, and synthetic precursors of such processes. More particularly, the present invention relates to the preparation of 2- substituted azaindoles from an ortho-gem-dihalovinylaminopyridine or from an ortho- gem-dihalovinylaminopyridine N-oxide compound and an organoboron reagent using a palladium metal pre-catalyst, base and a ligand. The present invention also relates to the preparation of 2-substituted thienopyrroles from an ortho-gem-dihalovinylthiophene compound and an organoboron reagent using a palladium metal pre-catalyst, base and a ligand. The present invention also relates to processes for the production of ortho-gem- dihalovinylaminopyridines which are useful as starting materials in the production of 2- substituted azaindoles, and novel compounds prepared by the processes. The present invention also relates to processes for the production of ortho-gem-dihalovinylthiophenes which are useful as starting materials in the production of 2-substituted thienopyrroles, and novel compounds prepared by the processes. Formulae (V) and (VII).