CAS: 3430-31-7; 3-Bromo-2,6-Dimethylpyridine

该化合物是三环有机化合物,其特征是2和6个位置上用两组甲基组取代的环和3个位置上的溴原子.该化合物的分子式为C8H10BRN,其芳香环内含有氮原子,有助于其基本性和潜在反应性.溴原子的存在引入了卤素,这可以增强化合物的遗传性,使其在各种化学反应中有用,包括核细胞替代.3-Bromo-2,6-二甲基丙烯通常无色可粉黄液或固体,视其纯度和形态而定.该化合物在有机溶剂中可溶解,并可能具有中度毒性,在处理过程中需要适当的安全防范.该化合物经常用于有机合成,特别是在研制药品和农用化学品时,因为其有能力参与多种化学转化.

英文名称3-Bromo-2,6-Dimethylpyridine
中文名称2,6-二甲基-3-溴吡啶
IUPAC名称3-bromo-2,6-dimethylpyridine
其它别名2,6-二甲基-3-溴吡啶(Cas号:3430-31-7); 2,6-Dimethyl-3-Bromopyridine
CAS编号3430-31-7
MFCD编号:MFCD00235164
EINECS号:685-732-4
分子式:C7H8BrN
分子量:186.05
产品CID: 1344758
产品分类有机原料→分子砌块→芳杂环类化合物→吡啶类化合物

相似结构搜索
InChIKey: TUJVGHCSNXCAFE-UHFFFAOYSA-N
InChI=1S/C7H8BrN/c1-5-3-4-7(8)6(2)9-5/h3-4H,1-2H3…
计算化学: 氢键受体数1.0氢键供体数0.0可旋转键数0.0

相似化合物

3430-34-0 38749-87-0 38749-79-0

MSDS等安全信息

GHS象形图
GHS符号GHS07 & GHS05;
注释: Exclamation mark & Corrosion
危险类别特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼损伤类别1
严重眼刺激类别2
警示词Danger(危险)
危险描述H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H318 |造成严重眼损伤.
H319 |造成严重眼刺激.
防范说明P210-P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P370+P378-P403-P405-P501
危险等级8
UN编号1760.0
危险品标志Xi,Xn
包装等级Ⅲ
安全声明26-36/37/39-36/39
危险类别码36/37/38-41-37/38-22
WGK Germany3

欧盟法规

ECHA物质C&L通报

上下游产品

合成工艺路线路线简述

2,6-二甲基吡啶置于发烟硫酸,溴体系中,化学反应 5.0H,以48.6%的收率获得2,6-二甲基-3-溴吡啶
参考文献:顺磁性NMR光谱法测定不稳定的中间酶的3D结构
标题:顺磁性NMR光谱法测定不稳定的中间酶的3D结构
摘要:酶催化依赖于构象可塑性,但很难获得有关瞬态中间体的结构信息.我们表明,可以通过核磁共振(NMR)光谱确定不稳定,低丰度酶促中间体的三维(3D)结构.该方法已针对金黄色葡萄球菌进行了证明分选酶a(srta),它是既定的药物靶标和生物技术试剂.Srta是将底物肽的酰胺键转化为硫酯的转肽酶.通过测量由不与活性位点残基cys184反应的位点特异性半胱氨酸反应性顺磁性标签产生的伪接触位移(pcs),收集了足够数量的约束物来确定srta不稳定硫酯中间体的3D结构,从而在非平衡条件下仅作为次要物种存在.3D结构揭示了保护硫酯中间体免于水解的结构变化.
Doi:10.1002/anie.201606223

海关参考信息

2933310010-吡啶
2939800000-其他生物碱
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-6166031-A
优先权日:1987-10-19
标题:Substituted tetralins, chromans and related compounds in the treatment of asthma
发明人：EGGLER JAMES F; MARFAT ANTHONY; MELVIN JR LAWRENCE S
权利人:PFIZER
摘要:Substituted tetralins, chromans and related compounds which, by inhibiting 5-lipoxygenase enzyme and/or blocking leukotriene receptors, are useful in the prevention or treatment of asthma, arthritis, psoriasis, ulcers, myocardial infarction and related disease states in mammals; pharmaceutical compositions comprising said compounds; a method of treatment with said compounds; and intermediates useful in the synthesis of said compounds.

专利号:US-5149814-A
优先权日:1987-09-30
标题:Alkyl 2-benzylidene-4-(2-alkylimidazopyrid-1-yl) benzoylacetate esters as intermediate compounds
发明人：COOPER KELVIN; FRAY MICHAEL J; RICHARDSON KENNETH; STEELE JOHN
权利人:PFIZER
摘要:Intermediates useful in the synthesis of dihydropyridine platelet activating factor antagonists of the formula ##STR1## where R is phenyl or substituted phenyl; R 3 is lower alkyl; Y is 1,4-phenylene and X is 2-alkylimidazopyridyl.

专利号:US-5998451-A
优先权日:1987-10-19
标题 :Substituted tetralins, chromans and related compounds in the treatment and related compounds in the treatment of asthma, arthritis and related diseases
发明人：EGGLER JAMES F; MARFAT ANTHONY; MELVIN JR LAWRENCE S
权利人:PFIZER
摘要:Substituted tetralins, chromans and related compounds which, by inhibiting 5-lipoxygenase enzyme and/or blocking leukotriene receptors, are useful in the prevention or treatment of asthma, arthritis, psoriasis, ulcers, myocardial infarction and related disease states in mammals, pharmaceutical compositions thereof, a method of treatment therewith, and to intermediates useful in the synthesis thereof.

专利号:US-5070205-A
优先权日:1987-09-30
标题:Alkyl 2-benzylidene-4-(benzimidazol-1-yl) benzoylacetate esters as intermediates
发明人：COOPER MELVIN; FRAY MICHAEL J; RICHARDSON KENNETH; STEELE JOHN
权利人:PFIZER
摘要:Intermediates useful in the synthesis of dihydropyridine platelet activating factor antagonists of the formula ##STR1## where R is phenyl or substituted phenyl; R 3 is lower alkyl; Y is 1,4-phenylene and X is a benzimidazol-1-yl.

专利号:US-2025042877-A1
优先权日:2021-11-30
标题:Organic compound, organic device, light-emitting apparatus, and electronic appliance
发明人：HAYASHI YUKI; KAWAKAMI SACHIKO; HASHIMOTO NAOAKI
权利人:SEMICONDUCTOR ENERGY LAB
摘要:A novel compound, a synthesis method thereof, and an organic device including the novel compound are provided. A compound represented by General Formula (G1) is provided. In General Formula (G1), each of R1, R2, and R5 to R7 independently represents any of hydrogen (including deuterium), an alkyl group having 1 to 10 carbon atoms, a substituted or unsubstituted aryl group having 1 to 60 carbon atoms, and a substituted or unsubstituted heteroaryl group having 1 to 60 carbon atoms. R3 represents a condensed ring composed of 4 to 10 rings containing nitrogen as an element forming the ring, and R4 represents any of a substituted or unsubstituted condensed ring having 1 to 60 carbon atoms, a substituted or unsubstituted aryl group with a molecular weight of 78 or more, and a substituted or unsubstituted heteroaryl group with a molecular weight of 80 or more. At least one of A1 to A3 represents nitrogen, and each of the others represents substituted carbon. Each of substituents of A1 to A3 independently represents any of hydrogen (including deuterium), an alkyl group having 1 to 10 carbon atoms, a substituted or unsubstituted aryl group having 1 to 60 carbon atoms, and a substituted or unsubstituted heteroaryl group having 1 to 60 carbon atoms.

专利号:US-8093229-B2
优先权日:2005-03-30
标题 :Alkynyl pyrrolo[2,3-d]pyrimidines and related analogs as HSP90-inhibitors
发明人：KASIBHATLA SRINIVAS RAO; BIAMONTE MARCO ANTONIO; SHI JIANDONG; BOEHM MARCUS F
权利人:KASIBHATLA SRINIVAS RAO; BIAMONTE MARCO ANTONIO; SHI JIANDONG; BOEHM MARCUS F; CONFORMA THERAPEUTICS CORP
摘要:Alkynyl pyrrolo [2,3-d] pyrimidines of Formula I are described and demonstrated to have utility as Heat Shock Protein 90 (HSP90) inhibiting agents used in the treatment and prevention of various HSP90 mediated disorders. Methods of synthesis and use of such compounds are also described and claimed.