CAS: 22614-69-3; 8-Methoxyquinolin-2(1H)-One

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📜8-甲氧基喹啉氮氧化物置于1,8-Dimethoxy-10-Phenyl-9-(O-Tolyl)Acridin-10-Ium Chloride体系中,用 二甲基亚砜 用作溶剂,化学反应 8.0H,以94%的收率获得8-甲氧基喹啉-2-酮
参考文献:从喹啉n-氧化物中高效可见光介导的喹啉-2(1H)-酮的合成
标题:从喹啉n-氧化物中高效可见光介导的喹啉-2(1H)-酮的合成
摘要:Quinolin-2( 1H )-Ones 是一类重要的化合物,因为它们普遍存在于天然产物和药理学上有用的化合物中.在这里,我们提出了一种非常规且迄今为止未知的光催化方法,从容易获得的喹啉-N-氧化物合成它们.这种不含试剂的高原子经济性光催化方法具有低催化剂负载,高产率和无不良副产物,为迄今为止报道的所有常规合成提供了一种更有效的绿色替代方案.该方法的稳健性已成功证明,可轻松扩展到克级.
Doi:10.1039/d1Gc01460A

专利信息

专利号:US-9302992-B2
优先权日:2013-04-02
标 题:Multifunctional quinoline derivatives as anti-neurodegenerative agents
发明人：CHERN JI-WANG; HUANG CHEN-WEI; CHANG PEI-TEH; TALEKAR RAHUL SUBHASH
权利人:ANNJI PHARM CO LTD
摘要:Novel quinoline derivatives are disclosed. Also disclosed are synthesis and use thereof for treating neurodegenerative diseases. In one aspect, the invention relates to a compound of Formula (I) or a pharmaceutically acceptable salt thereof: n n(I) whereinn R 1 is hydrogen, (C 1 -C 8 )alkyl, (C 1 -C 8 )alkylene(C 3 -C 8 )cycloalkyl, (C 1 -C 8 )haloalkyl, or (C 1 -C 8 )alkylene(C 6 -C 20 )aryl; R 2 is hydrogen or halogen; R 3 is hydrogen, halogen, (C 1 -C 8 )alkyl, or (C 1 -C 8 )alkoxy; R 4 is hydrogen, halogen, (C 1 -C 8 )alkyl, (C 1 -C 8 )alkoxy, or (C 1 -C 8 )haloalkyl; R 5 is hydrogen or (C 1 -C 20 )alkanol; R 6 is hydrogen; and R 7 is (C 1 -C 20 )alkanol, (C 1 -C 8 )alkylene (C 3 -C 8 )heterocyclyl(C 1 -C 20 )alkanol, (C 1 -C 8 )alkylene (C 3 -C 8 )heterocyclyl(C 1 -C 20 )alkyl, (C 1 -C 8 )alkylene(C 1 -C 6 )alkylamino(C 1 -C 6 )alkynyl, (C 1 -C 8 )alkyleneamino(C 1 -C 20 )alkanol, or (C 1 -C 8 )alkyleneamino(C 1 -C 20 )alkanol(C 1 -C 8 )alkylene substituted (C 3 -C 20 )heteroaryl;n n(II) or wherein:n R 1 , R 2 , R 3 , R 4 and R 6 are each defined in (I) above; R 5 is (C 1 -C 20 )alkanol; and R 7 is hydrogen, (C 1 -C 20 )alkanol, (C 1 -C 8 )alkylene (C 3 -C 8 )heterocyclyl(C 1 -C 20 )alkanol, (C 1 -C 8 )alkylene (C 3 -C 8 )heterocyclyl(C 1 -C 20 )alkyl, (C 1 -C 8 )alkylene(C 1 -C 6 )alkylamino(C 1 -C 6 )alkynyl, (C 1 -C 8 )alkyleneamino(C 1 -C 20 )alkanol, or (C 1 -C 8 )alkyleneamino(C 1 -C 20 )alkanol(C 1 -C 8 )alkylene substituted (C 3 -C 20 )heteroaryl.